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Ongoing studies have identified similarities between neural representations in biological networks and in deep artificial neural networks. This has led to renewed interest in developing analogies between the backpropagation learning…

Neural and Evolutionary Computing · Computer Science 2019-06-11 Theodore H. Moskovitz , Ashok Litwin-Kumar , L. F. Abbott

Interest in biologically inspired alternatives to backpropagation is driven by the desire to both advance connections between deep learning and neuroscience and address backpropagation's shortcomings on tasks such as online, continual…

Neural and Evolutionary Computing · Computer Science 2020-06-18 Jack Lindsey , Ashok Litwin-Kumar

Backpropagation is widely used to train artificial neural networks, but its relationship to synaptic plasticity in the brain is unknown. Some biological models of backpropagation rely on feedback projections that are symmetric with…

Neurons and Cognition · Quantitative Biology 2023-02-08 Navid Shervani-Tabar , Robert Rosenbaum

Stochastic gradient descent with backpropagation is the workhorse of artificial neural networks. It has long been recognized that backpropagation fails to be a biologically plausible algorithm. Fundamentally, it is a non-local procedure --…

Machine Learning · Statistics 2021-12-24 Ganlin Song , Ruitu Xu , John Lafferty

Feedback alignment algorithms are an alternative to backpropagation to train neural networks, whereby some of the partial derivatives that are required to compute the gradient are replaced by random terms. This essentially transforms the…

Machine Learning · Computer Science 2023-06-06 Dominique Chu , Florian Bacho

Models of sensory processing and learning in the cortex need to efficiently assign credit to synapses in all areas. In deep learning, a known solution is error backpropagation, which however requires biologically implausible weight…

Neurons and Cognition · Quantitative Biology 2024-02-05 Kevin Max , Laura Kriener , Garibaldi Pineda García , Thomas Nowotny , Ismael Jaras , Walter Senn , Mihai A. Petrovici

Backpropagation is the cornerstone of deep learning, but its reliance on symmetric weight transport and global synchronization makes it computationally expensive and biologically implausible. Feedback alignment offers a promising…

Machine Learning · Computer Science 2025-05-28 Jeonghwan Cheon , Jaehyuk Bae , Se-Bum Paik

Despite being the workhorse of deep learning, the backpropagation algorithm is no panacea. It enforces sequential layer updates, thus preventing efficient parallelization of the training process. Furthermore, its biological plausibility is…

Machine Learning · Statistics 2021-02-18 Julien Launay , Iacopo Poli , François Boniface , Florent Krzakala

In artificial neural networks trained with gradient descent, the weights used for processing stimuli are also used during backward passes to calculate gradients. For the real brain to approximate gradients, gradient information would have…

Neurons and Cognition · Quantitative Biology 2020-02-04 Jordan Guerguiev , Konrad P. Kording , Blake A. Richards

Artificial neural networks are most commonly trained with the back-propagation algorithm, where the gradient for learning is provided by back-propagating the error, layer by layer, from the output layer to the hidden layers. A recently…

Machine Learning · Statistics 2016-12-22 Arild Nøkland

The feedback alignment (FA) algorithm offers a biologically plausible alternative to backpropagation (BP) for training neural networks yet notably fails to scale to convolutional architectures. Modifications have been proposed to address…

Artificial Intelligence · Computer Science 2026-05-12 Jake Lance , Larry Kieu

Current algorithms for deep learning probably cannot run in the brain because they rely on weight transport, where forward-path neurons transmit their synaptic weights to a feedback path, in a way that is likely impossible biologically. An…

Machine Learning · Computer Science 2020-01-13 Mohamed Akrout , Collin Wilson , Peter C. Humphreys , Timothy Lillicrap , Douglas Tweed

The development of biologically-plausible learning algorithms is important for understanding learning in the brain, but most of them fail to scale-up to real-world tasks, limiting their potential as explanations for learning by real brains.…

Neural and Evolutionary Computing · Computer Science 2022-02-01 Maxence Ernoult , Fabrice Normandin , Abhinav Moudgil , Sean Spinney , Eugene Belilovsky , Irina Rish , Blake Richards , Yoshua Bengio

Learning depends on changes in synaptic connections deep inside the brain. In multilayer networks, these changes are triggered by error signals fed back from the output, generally through a stepwise inversion of the feedforward processing…

Neurons and Cognition · Quantitative Biology 2021-01-05 William F. Podlaski , Christian K. Machens

The back-propagation (BP) algorithm has been considered the de-facto method for training deep neural networks. It back-propagates errors from the output layer to the hidden layers in an exact manner using the transpose of the feedforward…

Neural and Evolutionary Computing · Computer Science 2018-05-01 Hongyin Luo , Jie Fu , James Glass

The vast majority of natural sensory data is temporally redundant. Video frames or audio samples which are sampled at nearby points in time tend to have similar values. Typically, deep learning algorithms take no advantage of this…

Neural and Evolutionary Computing · Computer Science 2017-06-14 Peter O'Connor , Efstratios Gavves , Max Welling

Backpropagation, a foundational algorithm for training artificial neural networks, predominates in contemporary deep learning. Although highly successful, it is widely considered biologically implausible, because it relies on precise…

Machine Learning · Computer Science 2025-10-07 Li Ji-An , Marcus K. Benna

Neuronal systems need to process temporal signals. We here show how higher-order temporal (co-)fluctuations can be employed to represent and process information. Concretely, we demonstrate that a simple biologically inspired feedforward…

Neurons and Cognition · Quantitative Biology 2023-09-13 Sandra Nestler , Moritz Helias , Matthieu Gilson

Feedback Alignment (FA) methods are biologically inspired local learning rules for training neural networks with reduced communication between layers. While FA has potential applications in distributed and privacy-aware ML, limitations in…

Machine Learning · Computer Science 2024-06-05 Zachary Robertson , Oluwasanmi Koyejo

Backpropagation is the default algorithm for training deep neural networks due to its simplicity, efficiency and high convergence rate. However, its requirements make it impossible to be implemented in a human brain. In recent years, more…

Machine Learning · Computer Science 2021-09-01 Albert Jiménez Sanfiz , Mohamed Akrout
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