English
Related papers

Related papers: OncoReason: Structuring Clinical Reasoning in LLMs…

200 papers

Multimodal Large Language Models (MLLMs) already achieve state-of-the-art results across a wide range of tasks and modalities. To push their reasoning ability further, recent studies explore advanced prompting schemes and post-training…

Artificial Intelligence · Computer Science 2025-09-09 Zhenyu Pan , Yutong Zhang , Jianshu Zhang , Haoran Lu , Haozheng Luo , Yuwei Han , Philip S. Yu , Manling Li , Han Liu

Mental health disorders impose a substantial global socioeconomic burden. While large language models (LLMs) offer 24/7, non-judgmental interactions to address this gap, pretrained models lack contextual coherence and emotional alignment…

Computation and Language · Computer Science 2026-02-17 Eric Hua Qing Zhang , Julia Ive

Large Language Models (LLMs) have shown strong potential in complex medical reasoning yet face diminishing gains under inference scaling laws. While existing studies augment LLMs with various knowledge types, it remains unclear how…

Artificial Intelligence · Computer Science 2026-02-10 Yu Zhao , Hao Guan , Yongcheng Jing , Ying Zhang , Dacheng Tao

Large language models (LLMs) have demonstrated remarkable capabilities in natural language understanding, reasoning, and problem-solving across various domains. However, their ability to perform complex, multi-step reasoning task-essential…

Large Language Models (LLMs) excel in diverse areas, yet struggle with complex scientific reasoning, especially in the field of chemistry. Different from the simple chemistry tasks (e.g., molecule classification) addressed in previous…

Computation and Language · Computer Science 2024-02-12 Siru Ouyang , Zhuosheng Zhang , Bing Yan , Xuan Liu , Yejin Choi , Jiawei Han , Lianhui Qin

Numerous decision-making tasks require estimating causal effects under interventions on different parts of a system. As practitioners consider using large language models (LLMs) to automate decisions, studying their causal reasoning…

Machine Learning · Computer Science 2024-12-24 Tejas Kasetty , Divyat Mahajan , Gintare Karolina Dziugaite , Alexandre Drouin , Dhanya Sridhar

Fine-tuning large language models (LLMs) for reasoning tasks using reinforcement learning methods like Group Relative Policy Optimization (GRPO) is computationally expensive. To address this, we propose a predictive framework that models…

Machine Learning · Computer Science 2026-03-23 Datta Nimmaturi , Vaishnavi Bhargava , Rajat Ghosh , Johnu George , Debojyoti Dutta

Reasoning capabilities in large language models (LLMs) have generally advanced significantly. However, it is still challenging for existing reasoning-based LLMs to perform effective decision-making abilities in multi-agent environments, due…

Computation and Language · Computer Science 2026-04-17 Jiashuo Wang , Jiawen Duan , Jian Wang , Kaitao Song , Chunpu Xu , Johnny K. W. Ho , Fenggang Yu , Wenjie Li , Johan F. Hoorn

Diffusion large language models (dLLMs) are promising alternatives to autoregressive large language models (AR-LLMs), as they potentially allow higher inference throughput. Reinforcement learning (RL) is a crucial component for dLLMs to…

Machine Learning · Computer Science 2026-02-24 Yuchen Zhu , Wei Guo , Jaemoo Choi , Petr Molodyk , Bo Yuan , Molei Tao , Yongxin Chen

Large Language Models (LLMs) have achieved high accuracy on medical question-answer (QA) benchmarks, yet their capacity for flexible clinical reasoning has been debated. Here, we asked whether advances in reasoning LLMs improve their…

Computation and Language · Computer Science 2026-01-21 Kie Shidara , Preethi Prem , Jonathan Kim , Anna Podlasek , Feng Liu , Ahmed Alaa , Danilo Bernardo

Existing benchmarks for evaluating the clinical reasoning capabilities of large language models (LLMs) often lack a clear definition of "clinical reasoning" as a construct, fail to capture the full breadth of interdependent tasks within a…

Accurate risk assessment in lung cancer screening is critical for enabling early cancer detection and minimizing unnecessary invasive procedures. The Lung CT Screening Reporting and Data System (Lung-RADS) has been widely used as the…

Machine Learning · Computer Science 2025-09-09 Chuang Niu , Ge Wang

Prediction of survival in patients diagnosed with a brain tumour is challenging because of heterogeneous tumour behaviours and responses to treatment. Better estimations of prognosis would support treatment planning and patient support.…

Machine Learning · Computer Science 2021-06-18 Colleen E. Charlton , Michael Tin Chung Poon , Paul M. Brennan , Jacques D. Fleuriot

Large language models (LLMs) have emerged as transformative tools in medicine, with strong capabilities in language understanding, reasoning, and structured information extraction. Radiation oncology is particularly well suited for LLM…

Despite the rapid expansion of Large Language Models (LLMs) in healthcare, robust and explainable evaluation of their ability to assess clinical trial reporting according to CONSORT standards remains an open challenge. In particular,…

Artificial Intelligence · Computer Science 2026-02-26 Sohyeon Jeon , Hyung-Chul Lee

Recent advances in large language models (LLMs) have enabled general-purpose systems to perform increasingly complex domain-specific reasoning without extensive fine-tuning. In the medical domain, decision-making often requires integrating…

Computation and Language · Computer Science 2025-08-14 Shansong Wang , Mingzhe Hu , Qiang Li , Mojtaba Safari , Xiaofeng Yang

Large language models (LLMs) are increasingly explored for their reasoning capabilities, yet their ability to perform structured, constraint-based optimization from natural language remains insufficiently understood. This study evaluates…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-18 Aasish Kumar Sharma , Julian Kunkel

Chain-of-thought (CoT) rationales, which provide step-by-step reasoning to derive final answers, benefit LLMs in both inference and training. Incorporating rationales, either by generating them before answering during inference, or by…

Computation and Language · Computer Science 2025-10-21 Wenhang Shi , Shuqing Bian , Yiren Chen , Xinyi Zhang , Zhe Zhao , Pengfei Hu , Wei Lu , Xiaoyong Du

Drug discovery is a complex and resource-intensive process, making early prediction of approval outcomes critical for optimizing research investments. While classical machine learning and deep learning methods have shown promise in drug…

Large language models (LLMs), especially Explicit Long Chain-of-Thought (CoT) reasoning models like DeepSeek-R1 and QWQ, have demonstrated powerful reasoning capabilities, achieving impressive performance in commonsense reasoning and…

Computation and Language · Computer Science 2025-08-13 Jiatong Li , Weida Wang , Qinggang Zhang , Junxian Li , Di Zhang , Changmeng Zheng , Shufei Zhang , Xiaoyong Wei , Qing Li