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Clinical decision-making requires reasoning over incomplete, imprecise, and linguistically expressed patient narratives. While large language models (LLMs) excel at extracting latent information from natural language, they lack the…

Artificial Intelligence · Computer Science 2026-05-26 Xiaoyang Fan , Yufan Cai , Zhe Hou , Jin Song Dong

Eliciting explicit, step-by-step reasoning traces from large language models (LLMs) has emerged as a dominant paradigm for enhancing model capabilities. Although such reasoning strategies were originally designed for problems requiring…

Computation and Language · Computer Science 2026-03-23 Xinyu Guo , Yazhou Zhang , Jing Qin

Large language models (LLMs) can achieve strong reasoning performance with sufficient computation, but they do not inherently know how much computation a task requires. We study budgeted inference-time reasoning for multiple tasks under a…

Artificial Intelligence · Computer Science 2026-01-08 Muyang Zhao , Qi Qi , Hao Sun

Long chain-of-thought (CoT) significantly enhances the reasoning capabilities of large language models (LLMs). However, extensive reasoning traces lead to inefficiencies and increased time-to-first-token (TTFT). We propose a training…

Computation and Language · Computer Science 2026-01-08 Roy Xie , David Qiu , Deepak Gopinath , Dong Lin , Yanchao Sun , Chong Wang , Saloni Potdar , Bhuwan Dhingra

Very large language models (LLMs) such as GPT-4 have shown the ability to handle complex tasks by generating and self-refining step-by-step rationales. Smaller language models (SLMs), typically with < 13B parameters, have been improved by…

Computation and Language · Computer Science 2025-03-05 Sohan Patnaik , Milan Aggarwal , Sumit Bhatia , Balaji Krishnamurthy

Large Language Models (LLMs) have shown to be capable of various tasks, yet their capability in interpreting and reasoning over tabular data remains an underexplored area. In this context, this study investigates from three core…

Computation and Language · Computer Science 2023-12-29 Tianyang Liu , Fei Wang , Muhao Chen

Predicting enzymatic reactions is crucial for applications in biocatalysis, metabolic engineering, and drug discovery, yet it remains a complex and resource-intensive task. Large Language Models (LLMs) have recently demonstrated remarkable…

Artificial Intelligence · Computer Science 2025-05-12 Lorenzo Di Fruscia , Jana Marie Weber

This paper presents a learning-based guidance-and-control approach that couples a reasoning-enabled Large Language Model (LLM) with Group Relative Policy Optimization (GRPO). A two-stage procedure consisting of Supervised Fine-Tuning (SFT)…

Robotics · Computer Science 2026-01-09 Amit Jain , Richard Linares

One of the major barriers to using large language models (LLMs) in medicine is the perception they use uninterpretable methods to make clinical decisions that are inherently different from the cognitive processes of clinicians. In this…

Computation and Language · Computer Science 2023-08-15 Thomas Savage , Ashwin Nayak , Robert Gallo , Ekanath Rangan , Jonathan H Chen

As knowledge and semantics on the web grow increasingly complex, enhancing Large Language Models (LLMs)' comprehension and reasoning capabilities has become particularly important. Chain-of-Thought (CoT) prompting has been shown to enhance…

Artificial Intelligence · Computer Science 2026-01-21 Ke Chen , Jiandian Zeng , Zihao Peng , Guo Li , Guangxue Zhang , Tian Wang

Despite the significant improvements achieved by large language models (LLMs) in English reasoning tasks, these models continue to struggle with multilingual reasoning. Recent studies leverage a full-parameter and two-stage training…

Computation and Language · Computer Science 2025-01-08 Yuchun Fan , Yongyu Mu , Yilin Wang , Lei Huang , Junhao Ruan , Bei Li , Tong Xiao , Shujian Huang , Xiaocheng Feng , Jingbo Zhu

Large language models (LLMs) have recently emerged as powerful tools, finding many medical applications. LLMs' ability to coalesce vast amounts of information from many sources to generate a response-a process similar to that of a human…

Chain-of-Thought (CoT) reasoning has proven effective in enhancing large language models by encouraging step-by-step intermediate reasoning, and recent advances have extended this paradigm to Multimodal Large Language Models (MLLMs). In the…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Juntao Jiang , Jiangning Zhang , Yali Bi , Jinsheng Bai , Weixuan Liu , Weiwei Jin , Zhucun Xue , Yong Liu , Xiaobin Hu , Shuicheng Yan

Large Language Models (LLMs) and causal learning each hold strong potential for clinical decision making (CDM). However, their synergy remains poorly understood, largely due to the lack of systematic benchmarks evaluating their integration…

Machine Learning · Computer Science 2025-11-14 Linna Wang , Zhixuan You , Qihui Zhang , Jiunan Wen , Ji Shi , Yimin Chen , Yusen Wang , Fanqi Ding , Ziliang Feng , Li Lu

Clinical oncology generates vast, unstructured data that often contain inconsistencies, missing information, and ambiguities, making it difficult to extract reliable insights for data-driven decision-making. General-purpose large language…

Computation and Language · Computer Science 2025-03-12 Morteza Rohanian , Tarun Mehra , Nicola Miglino , Farhad Nooralahzadeh , Michael Krauthammer , Andreas Wicki

Large Language Models (LLMs) such as GPT-4 and LLaMA have demonstrated remarkable reasoning abilities but require significant computational resources for fine-tuning. This paper presents a resource-efficient fine-tuning approach for…

Computation and Language · Computer Science 2025-10-07 Imran Mansha

Medical question answering requires advanced reasoning that integrates domain knowledge with logical inference. However, existing large language models (LLMs) often generate reasoning chains that lack factual accuracy and clinical…

Computation and Language · Computer Science 2025-12-09 Chia-Hsuan Hsu , Jun-En Ding , Hsin-Ling Hsu , Chih-Ho Hsu , Li-Hung Yao , Chun-Chieh Liao , Feng Liu , Fang-Ming Hung

Background: More than 80% of U.S. cancer care is delivered in community settings, where survival remains worse than at academic centers. Clinicians must integrate genomics, staging, radiology, pathology, and changing guidelines, creating…

Mathematical reasoning is essential for problem-solving in education, science, and industry, serving as a crucial benchmark for evaluating artificial intelligence systems. As Large Language Models (LLMs) improve their reasoning…

Computation and Language · Computer Science 2026-05-20 Husnain Amjad , Raja Khurram Shahzad , Aamir Shahzad , Mehwish Fatima

The enhancement of reasoning capabilities in large language models (LLMs) has garnered significant attention, with supervised fine-tuning (SFT) and reinforcement learning emerging as dominant paradigms. While recent studies recognize the…

Artificial Intelligence · Computer Science 2026-03-17 Zhijie Wang
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