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Finetuning a Large Language Model (LLM) is crucial for generating results towards specific objectives. This research delves into the realm of drug optimization and introduce a novel reinforcement learning algorithm to finetune a drug…

Machine Learning · Computer Science 2025-02-12 Xuefeng Liu , Songhao Jiang , Siyu Chen , Zhuoran Yang , Yuxin Chen , Ian Foster , Rick Stevens

Objective: Large Language Models (LLMs) demonstrate significant capabilities in medical text understanding and generation. However, their diagnostic reliability in complex clinical scenarios remains limited. This study aims to enhance LLMs'…

Computation and Language · Computer Science 2025-08-04 Peixian Li , Yu Tian , Ruiqi Tu , Chengkai Wu , Jingjing Ren , Jingsong Li

Recently, large models have shown significant potential for smart healthcare. However, the deployment of Large Vision-Language Models (LVLMs) for clinical services is currently hindered by three critical challenges: a tendency to…

Artificial Intelligence · Computer Science 2025-10-27 Siyong Chen , Jinbo Wen , Jiawen Kang , Tenghui Huang , Xumin Huang , Yuanjia Su , Hudan Pan , Zishao Zhong , Dusit Niyato , Shengli Xie , Dong In Kim

Continual instruction tuning(CIT) during the post-training phase is crucial for adapting multimodal large language models (MLLMs) to evolving real-world demands. However, the progress is hampered by the lack of benchmarks with rigorous,…

Computation and Language · Computer Science 2026-02-16 Haiyun Guo , Zhiyan Hou , Yandu Sun , Jinghan He , Yu Chen , Yuzhe Zhou , Yuheng Jia , Jinqiao Wang , Tat-Seng Chua

Large Language Models (LLMs) have shown impressive performance on complex tasks through Chain-of-Thought (CoT) reasoning. However, conventional CoT relies on explicitly verbalized intermediate steps, which constrains its broader…

Computation and Language · Computer Science 2025-11-04 Xinghao Chen , Anhao Zhao , Heming Xia , Xuan Lu , Hanlin Wang , Yanjun Chen , Wei Zhang , Jian Wang , Wenjie Li , Xiaoyu Shen

We study clinical trial table reasoning, where answers are not directly stored in visible cells but must be reasoned from semantic understanding through normalization, classification, extraction, or lightweight domain reasoning. Motivated…

The advancement of Large Language Models (LLMs) for domain applications in fields such as materials science and engineering depends on the development of fine-tuning strategies that adapt models for specialized, technical capabilities. In…

Computation and Language · Computer Science 2024-09-06 Wei Lu , Rachel K. Luu , Markus J. Buehler

Large language models (LLMs) are reshaping the recommender system paradigm by enabling users to express preferences and receive recommendations through conversations. Yet, aligning LLMs to the recommendation task remains challenging:…

Information Retrieval · Computer Science 2026-02-17 Yaochen Zhu , Harald Steck , Dawen Liang , Yinhan He , Vito Ostuni , Jundong Li , Nathan Kallus

We present Team asdfo123's submission to the LLMSR@XLLM25 shared task, which evaluates large language models on producing fine-grained, controllable, and interpretable reasoning processes. Systems must extract all problem conditions,…

Computation and Language · Computer Science 2025-05-20 Xinye Li , Mingqi Wan , Dianbo Sui

The growing disparity between the exponential scaling of computational resources and the finite growth of high-quality text data now constrains conventional scaling approaches for large language models (LLMs). To address this challenge, we…

Explicit chain-of-thought (CoT) reasoning substantially improves the reasoning ability of large language models (LLMs), but incurs high inference cost due to lengthy autoregressive traces. Existing latent reasoning methods offer a promising…

Computation and Language · Computer Science 2026-05-26 Hui Xie , Jie Liu , Ziyue Qiao , Joaquin Vanschore

Recently, reinforcement learning (RL)-based tuning has shifted the trajectory of Multimodal Large Language Models (MLLMs), particularly following the introduction of Group Relative Policy Optimization (GRPO). However, directly applying it…

Computation and Language · Computer Science 2025-05-21 Wenhui Zhu , Xuanzhao Dong , Xin Li , Peijie Qiu , Xiwen Chen , Abolfazl Razi , Aris Sotiras , Yi Su , Yalin Wang

Recent reasoning large language models (LLMs) have demonstrated remarkable improvements in mathematical reasoning capabilities through long Chain-of-Thought. The reasoning tokens of these models enable self-correction within reasoning…

Artificial Intelligence · Computer Science 2025-04-02 Yu Cui , Bryan Hooi , Yujun Cai , Yiwei Wang

Reinforcement learning with verifiable reward (RLVR) has been instrumental in eliciting strong reasoning capabilities from large language models (LLMs) via long chains of thought (CoT). During RLVR training, we formalize and systemically…

Computation and Language · Computer Science 2026-02-24 Cheonbok Park , Jeonghoon Kim , Joosung Lee , Sanghwan Bae , Jaegul Choo , Kang Min Yoo

Large vision-language models (VLMs) fine-tuned on specialized visual instruction-following data have exhibited impressive language reasoning capabilities across various scenarios. However, this fine-tuning paradigm may not be able to…

Artificial Intelligence · Computer Science 2024-10-10 Yuexiang Zhai , Hao Bai , Zipeng Lin , Jiayi Pan , Shengbang Tong , Yifei Zhou , Alane Suhr , Saining Xie , Yann LeCun , Yi Ma , Sergey Levine

In the rapidly evolving field of Explainable Natural Language Processing (NLP), textual explanations, i.e., human-like rationales, are pivotal for explaining model predictions and enriching datasets with interpretable labels. Traditional…

Computation and Language · Computer Science 2025-11-12 Mahdi Dhaini , Juraj Vladika , Ege Erdogan , Zineb Attaoui , Gjergji Kasneci

Large language models are often assumed to acquire increasingly structured, generalizable internal representations simply by scaling data and parameters. We interrogate this assumption by introducing a Clinical Trial Natural Language…

Artificial Intelligence · Computer Science 2025-08-15 Maël Jullien , Marco Valentino , André Freitas

Large language models (LLMs) equipped with chain-of-thought (CoT) achieve strong performance and offer a window into LLM behavior. However, recent evidence suggests that improvements in CoT capabilities often come with redundant reasoning…

Computation and Language · Computer Science 2026-02-03 Yanrui Du , Sendong Zhao , Yibo Gao , Danyang Zhao , Qika Lin , Ming Ma , Jiayun Li , Yi Jiang , Kai He , Qianyi Xu , Bing Qin , Mengling Feng

In information retrieval, large language models (LLMs) have demonstrated remarkable potential in text reranking tasks by leveraging their sophisticated natural language understanding and advanced reasoning capabilities. However,…

Information Retrieval · Computer Science 2025-09-22 Haowei Liu , Xuyang Wu , Guohao Sun , Zhiqiang Tao , Yi Fang

Effective information seeking in multi-turn medical dialogues is critical for accurate diagnosis, especially when dealing with incomplete information. Aligning Large Language Models (LLMs) for these interactive scenarios is challenging due…

Machine Learning · Computer Science 2026-03-04 Ruike Cao , Shaojie Bai , Fugen Yao , Liang Dong , Jian Xu , Li Xiao