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Clustering algorithms became an essential part of the neurophysiological data analysis toolbox in the last twenty five years. Many problems, from the definition of cell types/groups based on morphological, molecular and physiological data…

Applications · Statistics 2025-09-23 Louise Martineau , Christophe Pouzat , Ségolen Geffray

Computed tomography for region-of-interest (ROI) reconstruction has advantages of reducing X-ray radiation dose and using a small detector. However, standard analytic reconstruction methods suffer from severe cupping artifacts, and existing…

Computer Vision and Pattern Recognition · Computer Science 2019-05-28 Yoseob Han , Jong Chul Ye

Topological correctness is critical for segmentation of tubular structures, which pervade in biomedical images. Existing topological segmentation loss functions are primarily based on the persistent homology of the image. They match the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-29 Bo Wen , Haochen Zhang , Dirk-Uwe G. Bartsch , William R. Freeman , Truong Q. Nguyen , Cheolhong An

Topological consistency plays a crucial role in the task of boundary segmentation for reticular images, such as cell membrane segmentation in neuron electron microscopic images, grain boundary segmentation in material microscopic images and…

Computer Vision and Pattern Recognition · Computer Science 2026-05-27 Chuni Liu , Boyuan Ma , Xiaojuan Ban , Yujie Xie , Hao Wang , Weihua Xue , Jingchao Ma , Ke Xu

Topology matters. Despite the recent success of point cloud processing with geometric deep learning, it remains arduous to capture the complex topologies of point cloud data with a learning model. Given a point cloud dataset containing…

Computer Vision and Pattern Recognition · Computer Science 2021-09-07 Jiahao Pang , Duanshun Li , Dong Tian

In clinical practice, human radiologists actually review medical images with high resolution monitors and zoom into region of interests (ROIs) for a close-up examination. Inspired by this observation, we propose a hierarchical graph neural…

Image and Video Processing · Electrical Eng. & Systems 2019-12-17 Hao Du , Jiashi Feng , Mengling Feng

Given the wide diffusion of deep neural network architectures for computer vision tasks, several new applications are nowadays more and more feasible. Among them, a particular attention has been recently given to instance segmentation, by…

Computer Vision and Pattern Recognition · Computer Science 2022-06-22 Leonardo Rossi , Akbar Karimi , Andrea Prati

Topology reasoning is crucial for autonomous driving. Current methods primarily focus on instance-level learning for centerline detection, followed by a sequential module for topology reasoning that relies on simplified MLP layers.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Yifeng Bai , Zhirong Chen , Erkang Cheng , Haibin Ling

Microscopic examination of slides prepared from tissue samples is the primary tool for detecting and classifying cancerous lesions, a process that is time-consuming and requires the expertise of experienced pathologists. Recent advances in…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Saba Fatema , Brighton Nuwagira , Sayoni Chakraborty , Reyhan Gedik , Baris Coskunuzer

Topological data analysis provides a set of tools to uncover low-dimensional structure in noisy point clouds. Prominent amongst the tools is persistence homology, which summarizes birth-death times of homological features using data objects…

Methodology · Statistics 2024-02-05 James Matuk , Sebastian Kurtek , Karthik Bharath

Understanding how the spatial structure of blood vessel networks relates to their function in healthy and abnormal biological tissues could improve diagnosis and treatment for diseases such as cancer. New imaging techniques can generate…

Quantitative Methods · Quantitative Biology 2019-07-23 Helen M Byrne , Heather A Harrington , Ruth Muschel , Gesine Reinert , Bernadette J Stolz , Ulrike Tillmann

Deep learning-based medical image segmentation techniques have shown promising results when evaluated based on conventional metrics such as the Dice score or Intersection-over-Union. However, these fully automatic methods often fail to meet…

Image and Video Processing · Electrical Eng. & Systems 2025-08-06 Liu Li , Qiang Ma , Cheng Ouyang , Johannes C. Paetzold , Daniel Rueckert , Bernhard Kainz

Topological correctness plays a critical role in many image segmentation tasks, yet most networks are trained using pixel-wise loss functions, such as Dice, neglecting topological accuracy. Existing topology-aware methods often lack robust…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Laurin Lux , Alexander H. Berger , Alexander Weers , Nico Stucki , Daniel Rueckert , Ulrich Bauer , Johannes C. Paetzold

Histopathology whole slide images (WSIs) are being widely used to develop deep learning-based diagnostic solutions, especially for precision oncology. Most of these diagnostic softwares are vulnerable to biases and impurities in the…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Abhijeet Patil , Harsh Diwakar , Jay Sawant , Nikhil Cherian Kurian , Subhash Yadav , Swapnil Rane , Tripti Bameta , Amit Sethi

fMRI (functional Magnetic Resonance Imaging) visual decoding involves decoding the original image from brain signals elicited by visual stimuli. This often relies on manually labeled ROIs (Regions of Interest) to select brain voxels.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 Ziyu Wang , Tengyu Pan , Zhenyu Li , Ji Wu , Xiuxing Li , Jianyong Wang

Standard fMRI connectivity analyses depend on aggregating the time series of individual voxels within regions of interest (ROIs). In certain cases, this spatial aggregation implies a loss of valuable functional and anatomical information…

Neurons and Cognition · Quantitative Biology 2019-08-12 Ruben Sanchez-Romero , Joseph D. Ramsey , Kun Zhang , Clark Glymour

Complex prediction models such as deep learning are the output from fitting machine learning, neural networks, or AI models to a set of training data. These are now standard tools in science. A key challenge with the current generation of…

Machine Learning · Computer Science 2022-10-21 Meng Liu , Tamal K. Dey , David F. Gleich

High-resolution microscopy images of tissue specimens provide detailed information about the morphology of normal and diseased tissue. Image analysis of tissue morphology can help cancer researchers develop a better understanding of cancer…

The study of irreducible higher-order interactions has become a core topic of study in complex systems. Two of the most well-developed frameworks, topological data analysis and multivariate information theory, aim to provide formal tools…

Information Theory · Computer Science 2025-04-15 Thomas F. Varley , Pedro A. M. Mediano , Alice Patania , Josh Bongard

Artificial Intelligence (AI) can potentially support histopathologists in the diagnosis of a broad spectrum of cancer types. In colorectal cancer (CRC), AI can alleviate the laborious task of characterization and reporting on resected…

Image and Video Processing · Electrical Eng. & Systems 2023-02-10 John-Melle Bokhorst , Iris D. Nagtegaal , Filippo Fraggetta , Simona Vatrano , Wilma Mesker , Michael Vieth , Jeroen van der Laak , Francesco Ciompi