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Artificial intelligence (AI) agents are emerging as transformative tools in drug discovery, with the ability to autonomously reason, act, and learn through complicated research workflows. Building on large language models (LLMs) coupled…

Agentic systems built on large language models (LLMs) offer promising capabilities for automating complex workflows in healthcare AI. We introduce mAIstro, an open-source, autonomous multi-agentic framework for end-to-end development and…

Machine Learning · Computer Science 2025-10-15 Eleftherios Tzanis , Michail E. Klontzas

Multi-agent systems (MAS) decompose complex tasks and delegate subtasks to different large language model (LLM) agents and tools. Prior studies have reported the superior accuracy performance of MAS across diverse domains, enabled by…

Multiagent Systems · Computer Science 2025-05-27 Mingyan Gao , Yanzi Li , Banruo Liu , Yifan Yu , Phillip Wang , Ching-Yu Lin , Fan Lai

With the development of foundation model (FM), agentic AI systems are getting more attention, yet their inherent issues like hallucination and poor reasoning, coupled with the frequent ad-hoc nature of system design, lead to unreliable and…

Artificial Intelligence · Computer Science 2026-01-28 Minh-Dung Dao , Quy Minh Le , Hoang Thanh Lam , Duc-Trong Le , Quoc-Viet Pham , Barry O'Sullivan , Hoang D. Nguyen

Current AI agent frameworks commit early to a single interaction protocol, a fixed tool integration strategy, and static user models, limiting their deployment across diverse interaction paradigms. To address these constraints, we introduce…

Artificial Intelligence · Computer Science 2026-03-25 Alfred Shen , Aaron Shen

Addressing Alzheimer's disease (AD) requires innovative strategies beyond current single-target drugs. This Letter to the Editor suggests that multitarget molecules, especially those targeting neuronal membrane protection, could offer a…

Biomolecules · Quantitative Biology 2024-06-04 Pablo Zambrano

Background: Globally we face a projected shortage of 11 million healthcare practitioners by 2030, and administrative burden consumes 50% of clinical time. Artificial intelligence (AI) has the potential to help alleviate these problems.…

Human-Computer Interaction · Computer Science 2025-08-01 Hashim Hayat , Maksim Kudrautsau , Evgeniy Makarov , Vlad Melnichenko , Tim Tsykunou , Piotr Varaksin , Matt Pavelle , Adam Z. Oskowitz

Recent advances in the data-driven medicine approach, which integrates ethically managed and explainable artificial intelligence into clinical decision support systems (CDSS), are critical to ensure reliable and effective patient care. This…

Artificial Intelligence · Computer Science 2025-09-23 Ying-Jung Chen , Ahmad Albarqawi , Chi-Sheng Chen

Leveraging multiple Large Language Models(LLMs) has proven effective for addressing complex, high-dimensional tasks, but current approaches often rely on static, manually engineered multi-agent configurations. To overcome these constraints,…

Machine Learning · Computer Science 2025-07-21 Xiaowen Ma , Chenyang Lin , Yao Zhang , Volker Tresp , Yunpu Ma

Artificial Intelligence (AI) has become essential in modern healthcare, with large language models (LLMs) offering promising advances in clinical decision-making. Traditional model-based approaches, including those leveraging in-context…

Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression…

Machine Learning · Computer Science 2018-12-07 Vipul Satone , Rachneet Kaur , Faraz Faghri , Mike A Nalls , Andrew B Singleton , Roy H Campbell

Securing Agentic Artificial Intelligence (AI) systems requires addressing the complex cyber risks introduced by autonomous, decision-making, and adaptive behaviors. Agentic AI systems are increasingly deployed across industries,…

Cryptography and Security · Computer Science 2025-12-23 Sunil Arora , John Hastings

Current mental-health conversational systems are usually based on fixed, generic dialogue patterns. This paper proposes an adaptive framework based on large language models that aims to personalize therapeutic interaction according to a…

Human-Computer Interaction · Computer Science 2025-11-26 Priyanka Singh , Sebastian Von Mammen

In this paper, we propose an Agentic Artificial Intelligence (AI) framework for wireless networks. The framework coordinates a pool of AI agents guided by Natural Language (NL) inputs from a human operator. At its core, the super agent is…

Networking and Internet Architecture · Computer Science 2026-04-07 Md Arafat Habib , Medhat Elsayed , Majid Bavand , Pedro Enrique Iturria Rivera , Yigit Ozcan , Melike Erol-Kantarci

Recent advancements in medical Large Language Models (LLMs) have showcased their powerful reasoning and diagnostic capabilities. Despite their success, current unified multimodal medical LLMs face limitations in knowledge update costs,…

Computation and Language · Computer Science 2025-06-25 Yucheng Zhou , Lingran Song , Jianbing Shen

AI agents have been developed for complex real-world tasks from coding to customer service. But AI agent evaluations suffer from many challenges that undermine our understanding of how well agents really work. We introduce the Holistic…

Software architecture design is a critical, yet inherently complex and knowledge-intensive phase of software development. It requires deep domain expertise, development experience, architectural knowledge, careful trade-offs among competing…

Software Engineering · Computer Science 2025-07-30 Ruiyin Li , Yiran Zhang , Xiyu Zhou , Peng Liang , Weisong Sun , Jifeng Xuan , Zhi Jin , Yang Liu

The rise of Agent AI and Large Language Model-powered Multi-Agent Systems (LLM-MAS) has underscored the need for responsible and dependable system operation. Tools like LangChain and Retrieval-Augmented Generation have expanded LLM…

Multiagent Systems · Computer Science 2025-02-05 Jinwei Hu , Yi Dong , Shuang Ao , Zhuoyun Li , Boxuan Wang , Lokesh Singh , Guangliang Cheng , Sarvapali D. Ramchurn , Xiaowei Huang

Accurate predictions of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) can enable effective personalized therapy. While cognitive tests and clinical data are routinely collected, they lack the predictive power…

Machine Learning · Computer Science 2025-11-11 Richard Hou , Shengpu Tang , Wei Jin

Large language models (LLMs) deployed as agents introduce significant safety risks in clinical settings due to their potential for error and single points of failure. We introduce Tiered Agentic Oversight (TAO), a hierarchical multi-agent…

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