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Spatial transcriptomics (ST) has revolutionized biomedical research by enabling high resolution gene expression profiling within tissues. However, the high cost and scarcity of high resolution ST data remain significant challenges. We…

Computer Vision and Pattern Recognition · Computer Science 2025-07-24 Yaoyu Fang , Jiahe Qian , Xinkun Wang , Lee A. Cooper , Bo Zhou

In this paper, we propose ZipAR, a training-free, plug-and-play parallel decoding framework for accelerating auto-regressive (AR) visual generation. The motivation stems from the observation that images exhibit local structures, and…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Yefei He , Feng Chen , Yuanyu He , Shaoxuan He , Hong Zhou , Kaipeng Zhang , Bohan Zhuang

Autoregressive models have emerged as a powerful paradigm for visual content creation, but often overlook the intrinsic structural properties of visual data. Our prior work, IAR, initiated a direction to address this by reorganizing the…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Ran Yi , Teng Hu , Zihan Su , Jiangning Zhang , Lizhuang Ma

Spatial transcriptomics (ST) enables mapping gene expression with spatial context but is severely affected by high sparsity and technical noise, which conceals true biological signals and hinders downstream analyses. To address these…

Machine Learning · Computer Science 2026-03-10 Sayeem Bin Zaman , Fahim Hafiz , Riasat Azim

With the rapid advancement of Spatial Resolved Transcriptomics (SRT) technology, it is now possible to comprehensively measure gene transcription while preserving the spatial context of tissues. Spatial domain identification and gene…

Genomics · Quantitative Biology 2024-08-14 Donghai Fang , Fangfang Zhu , Dongting Xie , Wenwen Min

Spatial transcriptomics (ST) enables the visualization of gene expression within the context of tissue morphology. This emerging discipline has the potential to serve as a foundation for developing tools to design precision medicines.…

Image and Video Processing · Electrical Eng. & Systems 2024-11-12 Shivam Kumar , Samrat Chatterjee

Single-cell RNA-sequencing technologies may provide valuable insights to the understanding of the composition of different cell types and their functions within a tissue. Recent technologies such as spatial transcriptomics, enable the…

Applications · Statistics 2023-05-16 Arhit Chakrabarti , Yang Ni , Bani K. Mallick

Autoregressive (AR) models have reformulated image generation as next-token prediction, demonstrating remarkable potential and emerging as strong competitors to diffusion models. However, control-to-image generation, akin to ControlNet,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Zongming Li , Tianheng Cheng , Shoufa Chen , Peize Sun , Haocheng Shen , Longjin Ran , Xiaoxin Chen , Wenyu Liu , Xinggang Wang

Computer Vision has proven to be a powerful tool for analyzing Spatial Transcriptomics (ST) data. However, current models that predict spatially resolved gene expression from histopathology images suffer from significant limitations due to…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Paula Cárdenas , Leonardo Manrique , Daniela Vega , Daniela Ruiz , Pablo Arbeláez

Recent advances in Spatial Transcriptomics (ST) pair histology images with spatially resolved gene expression profiles, enabling predictions of gene expression across different tissue locations based on image patches. This opens up new…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Aniruddha Ganguly , Debolina Chatterjee , Wentao Huang , Jie Zhang , Alisa Yurovsky , Travis Steele Johnson , Chao Chen

Spatial Transcriptomics is a groundbreaking technology that integrates histology images with spatially resolved gene expression profiles. Among the various Spatial Transcriptomics techniques available, Visium has emerged as the most widely…

Computer Vision and Pattern Recognition · Computer Science 2025-09-05 Daniela Ruiz , Paula Cárdenas , Leonardo Manrique , Daniela Vega , Gabriel M. Mejia , Pablo Arbeláez

Spatial transcriptomics (ST) measures gene expression at fine-grained spatial resolution, offering insights into tissue molecular landscapes. Previous methods for spatial gene expression prediction typically crop spots of interest from…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Ruikun Zhang , Yan Yang , Liyuan Pan

Autoregressive visual generation has garnered increasing attention due to its scalability and compatibility with other modalities compared with diffusion models. Most existing methods construct visual sequences as spatial patches for…

Computer Vision and Pattern Recognition · Computer Science 2025-06-13 Yuanhui Huang , Weiliang Chen , Wenzhao Zheng , Yueqi Duan , Jie Zhou , Jiwen Lu

Spatial transcriptomics is a modern sequencing technology that allows the measurement of the activity of thousands of genes in a tissue sample and map where the activity is occurring. This technology has enabled the study of the so-called…

Methodology · Statistics 2022-09-15 Andrea Sottosanti , Davide Risso

Recommendation model performance is intrinsically tied to the quality, volume, and relevance of their training data. To address common challenges like data sparsity and cold start, recent researchs have leveraged data from multiple…

Artificial Intelligence · Computer Science 2026-04-01 Jiaqing Zhang , Mingjia Yin , Hao Wang , Yuxin Tian , Yuyang Ye , Yawen Li , Wei Guo , Yong Liu , Enhong Chen

Spatial transcriptomics (ST) has emerged as an advanced technology that provides spatial context to gene expression. Recently, deep learning-based methods have shown the capability to predict gene expression from WSI data using ST data.…

Machine Learning · Computer Science 2024-12-10 Mingcheng Qu , Yuncong Wu , Donglin Di , Anyang Su , Tonghua Su , Yang Song , Lei Fan

Recent visual autoregressive (AR) models have shown promising capabilities in text-to-image generation, operating in a manner similar to large language models. While test-time computation scaling has brought remarkable success in enabling…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Joonhyung Park , Hyeongwon Jang , Joowon Kim , Eunho Yang

Single-cell spatial transcriptomics (ST) offers a unique approach to measuring gene expression profiles and spatial cell locations simultaneously. However, most existing ST methods assume that cells in closer spatial proximity exhibit more…

Genomics · Quantitative Biology 2025-06-10 Xiongtao Xiao , Xiaofeng Chen , Feiyan Jiang , Songming Zhang , Wenming Cao , Cheng Tan , Zhangyang Gao , Zhongshan Li

Recent image generation models show remarkable generation performance. However, they mirror strong location preference in datasets, which we call spatial bias. Therefore, generators render poor samples at unseen locations and scales. We…

Machine Learning · Computer Science 2021-08-04 Jooyoung Choi , Jungbeom Lee , Yonghyun Jeong , Sungroh Yoon

The rapid development of spatial transcriptomics (ST) technologies is revolutionizing our understanding of the spatial organization of biological tissues. Current ST methods, categorized into next-generation sequencing-based (seq-based) and…

Machine Learning · Computer Science 2024-07-19 Xiaoyu Li , Fangfang Zhu , Wenwen Min