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We propose a discrete latent distribution for Generative Adversarial Networks (GANs). Instead of drawing latent vectors from a continuous prior, we sample from a finite set of learnable latents. However, a direct parametrization of such a…

Computer Vision and Pattern Recognition · Computer Science 2023-05-02 Evangelos Ntavelis , Mohamad Shahbazi , Iason Kastanis , Radu Timofte , Martin Danelljan , Luc Van Gool

In this work we suggest a statistical mechanics approach to the classification of high-dimensional data according to a binary label. We propose an algorithm whose aim is twofold: First it learns a classifier from a relatively small number…

Statistical Mechanics · Physics 2009-07-22 Andrea Pagnani , Francesca Tria , Martin Weigt

While spatial transcriptomics (ST) has advanced our understanding of gene expression in tissue context, its high experimental cost limits its large-scale application. Predicting ST from pathology images is a promising, cost-effective…

Computer Vision and Pattern Recognition · Computer Science 2026-03-25 Zhiceng Shi , Changmiao Wang , Jun Wan , Wenwen Min

Generative Retrieval introduces a new approach to Information Retrieval by reframing it as a constrained generation task, leveraging recent advancements in Autoregressive (AR) language models. However, AR-based Generative Retrieval methods…

Computation and Language · Computer Science 2024-06-12 Ravisri Valluri , Akash Kumar Mohankumar , Kushal Dave , Amit Singh , Jian Jiao , Manik Varma , Gaurav Sinha

The techniques of data-driven backmapping from coarse-grained (CG) to fine-grained (FG) representation often struggle with accuracy, unstable training, and physical realism, especially when applied to complex systems such as proteins. In…

Machine Learning · Computer Science 2025-05-26 Georgios Kementzidis , Erin Wong , John Nicholson , Ruichen Xu , Yuefan Deng

Semantic image synthesis, i.e., generating images from user-provided semantic label maps, is an important conditional image generation task as it allows to control both the content as well as the spatial layout of generated images. Although…

Computer Vision and Pattern Recognition · Computer Science 2024-01-09 Tariq Berrada , Jakob Verbeek , Camille Couprie , Karteek Alahari

Sparse autoencoders (SAEs) have lately been used to uncover interpretable latent features in large language models. By projecting dense embeddings into a much higher-dimensional and sparse space, learned features become disentangled and…

Machine Learning · Computer Science 2025-07-30 Viktoria Schuster

Generative modeling of anatomical structures plays a crucial role in virtual imaging trials, which allow researchers to perform studies without the costs and constraints inherent to in vivo and phantom studies. For clinical relevance,…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Bram de Wilde , Max T. Rietberg , Guillaume Lajoinie , Jelmer M. Wolterink

Prevailing autoregressive (AR) models for text-to-image generation either rely on heavy, computationally-intensive diffusion models to process continuous image tokens, or employ vector quantization (VQ) to obtain discrete tokens with…

We develop a new framework for learning variational autoencoders and other deep generative models that balances generative and discriminative goals. Our framework optimizes model parameters to maximize a variational lower bound on the…

Machine Learning · Computer Science 2020-12-15 Gabriel Hope , Madina Abdrakhmanova , Xiaoyin Chen , Michael C. Hughes , Michael C. Hughes , Erik B. Sudderth

Deep generative models open new avenues for simulating realistic genomic data while preserving privacy and addressing data accessibility constraints. While previous studies have primarily focused on generating gene expression or haplotype…

Genomics · Quantitative Biology 2025-08-14 Sihan Xie , Thierry Tribout , Didier Boichard , Blaise Hanczar , Julien Chiquet , Eric Barrey

Generative adversarial networks (GANs) have been indicated their superiority in usage of the real-time speech synthesis. Nevertheless, most of them make use of deep convolutional layers as their backbone, which may cause the absence of…

Audio and Speech Processing · Electrical Eng. & Systems 2023-02-17 Zhenxing Lu , Mengnan He , Ruixiong Zhang , Caixia Gong

During embryonic development, differentiating cells respond via gene expression to positional cues from morphogen gradients. While gene expression is often highly erratic, embryonic development is precise. We show by theory and simulations…

Cell Behavior · Quantitative Biology 2015-05-13 Thorsten Erdmann , Martin Howard , Pieter Rein ten Wolde

Recent advances in large reconstruction and generative models have significantly improved scene reconstruction and novel view generation. However, due to compute limitations, each inference with these large models is confined to a small…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Shangjin Zhai , Zhichao Ye , Jialin Liu , Weijian Xie , Jiaqi Hu , Zhen Peng , Hua Xue , Danpeng Chen , Xiaomeng Wang , Lei Yang , Nan Wang , Haomin Liu , Guofeng Zhang

In recent years generative models of visual data have made a great progress, and now they are able to produce images of high quality and diversity. In this work we study representations learnt by a GAN generator. First, we show that these…

Computer Vision and Pattern Recognition · Computer Science 2020-06-19 Danil Galeev , Konstantin Sofiiuk , Danila Rukhovich , Mikhail Romanov , Olga Barinova , Anton Konushin

Document retrieval techniques are essential for developing large-scale information systems. The common approach involves using a bi-encoder to compute the semantic similarity between a query and documents. However, the scalar similarity…

Information Retrieval · Computer Science 2025-06-02 Haoyu Liu , Shaohan Huang , Jianfeng Liu , Yuefeng Zhan , Hao Sun , Weiwei Deng , Feng Sun , Furu Wei , Qi Zhang

Data-driven generative models excel in language and vision, but diffusion models often fail in constrained planning and design tasks, exhibiting severe constraint violations in engineering inverse design, molecular generation, multi-robot…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Zirui Zhao , Boye Niu , Harold Soh , David Hsu , Wee Sun Lee

Class-conditional generative models have emerged as accurate and robust classifiers, with diffusion models demonstrating clear advantages over other visual generative paradigms, including autoregressive (AR) models. In this work, we revisit…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Ilia Sudakov , Artem Babenko , Dmitry Baranchuk

We present a new approach for the analysis of genome-wide expression data. Our method is designed to overcome the limitations of traditional techniques, when applied to large-scale data. Rather than alloting each gene to a single cluster,…

Biological Physics · Physics 2009-11-07 Sven Bergmann , Jan Ihmels , Naama Barkai

This paper provides a framework in order to statistically model sequences from human genome, which is allowing a formulation to synthesize gene sequences. We start by converting the alphabetic sequence of genome to decimal sequence by…

Other Quantitative Biology · Quantitative Biology 2019-08-12 Salman Mohamadi , Farhang Yeganegi , Hamidreza Amindavar
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