Related papers: Mathematical Framework for Epidemic Dynamics: Opti…
Epidemiological models are best suitable to model an epidemic if the spread pattern is stationary. To deal with non-stationary patterns and multiple waves of an epidemic, we develop a hybrid model encompassing epidemic modeling, particle…
Mathematical modeling of disease outbreaks can infer the future trajectory of an epidemic, which can inform policy decisions. Another task is inferring the origin of a disease, which is relatively difficult with current mathematical models.…
Motivated by the swift global transmission of infectious diseases, we present a comprehensive framework for network-based epidemic control. Our aim is to curb epidemics using two different approaches. In the first approach, we introduce an…
Balancing the societal costs of non-pharmaceutical interventions with epidemic suppression requires adaptive feedback control. Rather than relying on state-dependent operational caps, we formulate an infinite-horizon optimal control problem…
The COVID-19 outbreak has stimulated the interest in the proposal of novel epidemiological models to predict the course of the epidemic so as to help planning effective control strategies. In particular, in order to properly interpret the…
We present and compare two different optimal control approaches applied to SEIR models in epidemiology, which allow us to obtain some policies for controlling the spread of an epidemic. The first approach uses Dynamic Programming to…
Susceptible-Exposed-Infectious-Recovered (SEIR) models with inter-individual variation in susceptibility or exposure to infection were proposed early in the COVID-19 pandemic as a potential element of the mathematical/statistical toolset…
Optimal intervention design is formulated as a hybrid optimal control problem for multiphase homogeneous epidemiological systems. The system extends a foundational compartmental model through intermediate phases that incorporate…
Modelling epidemics via classical population-based models suffers from shortcomings that so-called individual-based models are able to overcome, as they are able to take heterogeneity features into account, such as super-spreaders, and…
Epidemic spreading of infectious diseases is ubiquitous and has often considerable impact on public health and economic wealth. The large variability in spatio-temporal patterns of epidemics prohibits simple interventions and demands for a…
When effective medical treatment and vaccination are not available, non-pharmaceutical interventions such as social distancing, home quarantine and far-reaching shutdown of public life are the only available strategies to prevent the spread…
In this paper, we have studied epidemiological models for Ebola infection using nonlinear ordinary differential equations and optimal control theory. We considered optimal control analysis of SIR and SEIR models for the deadly Ebola…
This paper investigates the optimal control of an epidemic governed by a SEIR model with an operational delay in vaccination. We address the mathematical challenge of imposing hard healthcare capacity constraints (e.g., ICU limits) over an…
We consider the problem of the optimal allocation of vaccination and protection measures for the Susceptible-Infected-Recovered-Infected (SIRI) epidemiological model, which generalizes the classical Susceptible-Infected-Recovered (SIR) and…
We consider here an extended SIR model, including several features of the recent COVID-19 outbreak: in particular the infected and recovered individuals can either be detected (+) or undetected (-) and we also integrate an intensive care…
In this paper, we present a Distributionally Robust Markov Decision Process (DRMDP) approach for addressing the dynamic epidemic control problem. The Susceptible-Exposed-Infectious-Recovered (SEIR) model is widely used to represent the…
In this paper, we develop a robust economic model predictive controller for the containment of stochastic Susceptible-Exposed-Infected-Vigilant (SEIV) epidemic processes which drives the process to extinction quickly, while minimizing the…
We present a detailed set-based analysis of the well-known SIR and SEIR epidemic models subjected to hard caps on the proportion of infective individuals, and bounds on the allowable intervention strategies, such as social distancing,…
We present a modelling framework for the spreading of epidemics on temporal networks from which both the individual-based and pair-based models can be recovered. The proposed temporal pair-based model that is systematically derived from…
The spread of COVID-19 has been thwarted in most countries through non-pharmaceutical interventions. In particular, the most effective measures in this direction have been the stay-at-home and closure strategies of businesses and schools.…