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Cryo-electron tomography (cryo-ET) is an imaging technique that allows three-dimensional visualization of macro-molecular assemblies under near-native conditions. Cryo-ET comes with a number of challenges, mainly low signal-to-noise and…

Background: Single-particle cryo-electron microscopy (cryo-EM) has become a popular tool for structural determination of biological macromolecular complexes. High-resolution cryo-EM reconstruction often requires hundreds of thousands of…

Data Analysis, Statistics and Probability · Physics 2017-09-05 Yanan Zhu , Qi Ouyang , Youdong Mao

Analytical Dark Field Scanning Transmission Electron Microscopy (ADF-STEM) tomography reconstructs nanoscale materials in 3D by integrating multi-view tilt-series images, enabling precise analysis of their structural and compositional…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Beiyuan Zhang , Hesong Li , Ruiwen Shao , Ying Fu

In this work, we introduce the Geometry-Aware Large Reconstruction Model (GeoLRM), an approach which can predict high-quality assets with 512k Gaussians and 21 input images in only 11 GB GPU memory. Previous works neglect the inherent…

Computer Vision and Pattern Recognition · Computer Science 2024-10-29 Chubin Zhang , Hongliang Song , Yi Wei , Yu Chen , Jiwen Lu , Yansong Tang

Accurate and affordable indoor 3D reconstruction is critical for effective robot navigation and interaction. Traditional LiDAR-based mapping provides high precision but is costly, heavy, and power-intensive, with limited ability for novel…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Lu Chen , Yingfu Zeng , Haoang Li , Zhitao Deng , Jiafu Yan , Zhenjun Zhao

Cryo-electron microscopy (cryo-EM) is an imaging modality that provides unique insights into the dynamics of proteins and other building blocks of life. The algorithmic challenge of jointly estimating the poses, 3D structure, and…

Computer Vision and Pattern Recognition · Computer Science 2022-10-17 Axel Levy , Gordon Wetzstein , Julien Martel , Frederic Poitevin , Ellen D. Zhong

3D Gaussian Splatting (3DGS) has emerged as a promising 3D reconstruction technique. The traditional 3DGS training pipeline follows three sequential steps: Gaussian densification, Gaussian projection, and color splatting. Despite its…

Computer Vision and Pattern Recognition · Computer Science 2025-10-17 Junyi Wu , Jiaming Xu , Jinhao Li , Yongkang Zhou , Jiayi Pan , Xingyang Li , Guohao Dai

3D scene reconstruction is fundamental for spatial intelligence applications such as AR, robotics, and digital twins. Traditional multi-view stereo struggles with sparse viewpoints or low-texture regions, while neural rendering approaches,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Jiaqi Yao , Zhongmiao Yan , Jingyi Xu , Songpengcheng Xia , Yan Xiang , Ling Pei

Electron cryo-tomography (cryo-ET) enables 3D imaging of complex, radiation-sensitive structures with molecular detail. However, image contrast from the interference of scattered electrons is nonlinear with atomic density and multiple…

3D Gaussian Splatting (3DGS) has made significant strides in real-time 3D scene reconstruction, but faces memory scalability issues in high-resolution scenarios. To address this, we propose Hierarchical Gaussian Splatting (HRGS), a…

Computer Vision and Pattern Recognition · Computer Science 2025-06-18 Changbai Li , Haodong Zhu , Hanlin Chen , Juan Zhang , Tongfei Chen , Shuo Yang , Shuwei Shao , Wenhao Dong , Baochang Zhang

Generalizable 3D Gaussian Splatting reconstruction showcases advanced Image-to-3D content creation but requires substantial computational resources and large datasets, posing challenges to training models from scratch. Current methods…

Computer Vision and Pattern Recognition · Computer Science 2026-01-05 Xiufeng Huang , Ka Chun Cheung , Runmin Cong , Simon See , Renjie Wan

Different tasks in the computational pipeline of single-particle cryo-electron microscopy (cryo-EM) require enhancing the quality of the highly noisy raw images. To this end, we develop an efficient algorithm for signal enhancement of…

Image and Video Processing · Electrical Eng. & Systems 2022-12-06 Guy Sharon , Yoel Shkolnisky , Tamir Bendory

2D Gaussian Splatting has recently emerged as a significant method in 3D reconstruction, enabling novel view synthesis and geometry reconstruction simultaneously. While the well-known Gaussian kernel is broadly used, its lack of anisotropy…

Computer Vision and Pattern Recognition · Computer Science 2024-09-02 Ruihan Yu , Tianyu Huang , Jingwang Ling , Feng Xu

Efficient and high-fidelity reconstruction of deformable surgical scenes is a critical yet challenging task. Building on recent advancements in 3D Gaussian splatting, current methods have seen significant improvements in both reconstruction…

Computer Vision and Pattern Recognition · Computer Science 2025-01-03 Jiwei Shan , Zeyu Cai , Cheng-Tai Hsieh , Shing Shin Cheng , Hesheng Wang

Cryo-electron tomography (Cryo-ET) is a powerful tool in structural biology for 3D visualization of cells and biological systems at resolutions sufficient to identify individual proteins in situ. The measurements are collected by tilting…

Signal Processing · Electrical Eng. & Systems 2025-09-03 Vinith Kishore , Valentin Debarnot , AmirEhsan Khorashadizadeh , Ivan Dokmanić

3D Morphable Models (3DMMs) enable controllable facial geometry and expression editing for reconstruction, animation, and AR/VR, but traditional PCA-based mesh models are limited in resolution, detail, and photorealism. Neural volumetric…

3D Gaussian Splatting (3DGS) achieves an appealing balance between rendering quality and efficiency, but relies on approximating 3D Gaussians as 2D projections--an assumption that degrades accuracy, especially under generic large…

Graphics · Computer Science 2026-03-13 Zixun Huang , Cho-Ying Wu , Yuliang Guo , Xinyu Huang , Liu Ren

Cryogenic electron microscopy is widely used in structural biology, but its resolution is often limited by the dynamics of the macromolecule. Here, we developed a refinement protocol based on Gaussian mixture models that integrates particle…

Quantitative Methods · Quantitative Biology 2023-08-31 Muyuan Chen , Michael F. Schmid , Wah Chiu

Recently, 3D Gaussian Splatting (3DGS) has attracted widespread attention due to its high-quality rendering, and ultra-fast training and rendering speed. However, due to the unstructured and irregular nature of Gaussian point clouds, it is…

Computer Vision and Pattern Recognition · Computer Science 2025-01-13 Danpeng Chen , Hai Li , Weicai Ye , Yifan Wang , Weijian Xie , Shangjin Zhai , Nan Wang , Haomin Liu , Hujun Bao , Guofeng Zhang

3D reconstruction of medical images is a key technology in medical image analysis and clinical diagnosis, providing structural visualization support for disease assessment and surgical planning. Traditional methods are computationally…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Bin Liu , Wenyan Tian , Huangxin Fu , Zizheng Li , Zhifen He , Bo Li
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