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While interpretable prototype networks offer compelling case-based reasoning for clinical diagnostics, their raw continuous outputs lack the semantic structure required for medical documentation. Bridging this gap via standard…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Alvaro Lopez Pellicer , Plamen Angelov , Marwan Bukhari , Yi Li , Eduardo Soares , Jemma Kerns

Large language models (LLMs) have achieved remarkable success across a wide range of applications especially when augmented by external knowledge through retrieval-augmented generation (RAG). Despite their widespread adoption, recent…

Computation and Language · Computer Science 2026-04-14 Tianzhe Zhao , Jiaoyan Chen , Shuxiu Zhang , Haiping Zhu , Qika Lin , Jun Liu

The large-scale development of large language models (LLMs) in medical contexts, such as diagnostic assistance and treatment recommendations, necessitates that these models possess accurate medical knowledge and deliver traceable…

Artificial Intelligence · Computer Science 2025-08-12 Qiyuan Li , Haijiang Liu , Caicai Guo , Chao Gao , Deyu Chen , Meng Wang , Feng Gao , Frank van Harmelen , Jinguang Gu

Patient-clinician communication is an asymmetric-information problem: patients often do not disclose fears, misconceptions, or practical barriers unless clinicians elicit them skillfully. Effective medical dialogue therefore requires…

Computation and Language · Computer Science 2026-04-13 Yikun Han , Joey Chan , Jingyuan Chen , Mengting Ai , Simo Du , Yue Guo

Extracting structured information from clinical notes requires navigating a dense web of interdependent variables where the value of one attribute logically constrains others. Existing Large Language Model (LLM)-based extraction pipelines…

Access to the right evidence does not guarantee that large language models (LLMs) will reason with it correctly. This gap between retrieval and reasoning is especially concerning in clinical settings, where outputs must align with…

Artificial Intelligence · Computer Science 2025-11-21 Deepthi Potluri , Aby Mammen Mathew , Jeffrey B DeWitt , Alexander L. Rasgon , Yide Hao , Junyuan Hong , Ying Ding

In this work, we systematically expose and measure the inconsistency and knowledge gaps of Large Language Models (LLMs). Specifically, we propose an automated testing framework (called KonTest) which leverages a knowledge graph to construct…

Computation and Language · Computer Science 2025-08-15 Sai Sathiesh Rajan , Ezekiel Soremekun , Sudipta Chattopadhyay

Large Language Models (LLMs) often struggle with dynamically changing knowledge and handling unknown static information. Retrieval-Augmented Generation (RAG) is employed to tackle these challenges and has a significant impact on improving…

Computation and Language · Computer Science 2025-09-18 Zhen Zhang , Xinyu Wang , Yong Jiang , Zile Qiao , Zhuo Chen , Guangyu Li , Feiteng Mu , Mengting Hu , Pengjun Xie , Fei Huang

The applications of large language models (LLMs) have been widely spread across all domains. However, the basic abilities such as the controllability of LLMs are still limited. To address this, we propose "Self-controller", a novel agentic…

Computation and Language · Computer Science 2024-10-02 Xiao Peng , Xufan Geng

Large Language Models (LLMs) demonstrate potential in complex legal tasks like argument generation, yet their reliability remains a concern. Building upon pilot work assessing LLM generation of 3-ply legal arguments using human evaluation,…

Computation and Language · Computer Science 2025-06-04 Li Zhang , Morgan Gray , Jaromir Savelka , Kevin D. Ashley

Knowledge graphs (KGs) are the cornerstone of the semantic web, offering up-to-date representations of real-world entities and relations. Yet large language models (LLMs) remain largely static after pre-training, causing their internal…

Computation and Language · Computer Science 2026-03-24 Songlin Zhai , Guilin Qi , Yue Wang , Yuan Meng

The `pre-train, prompt, predict' paradigm of large language models (LLMs) has achieved remarkable success in open-domain question answering (OD-QA). However, few works explore this paradigm in the scenario of multi-document question…

Computation and Language · Computer Science 2023-12-27 Yu Wang , Nedim Lipka , Ryan A. Rossi , Alexa Siu , Ruiyi Zhang , Tyler Derr

Accurate clinical diagnosis requires extensive domain knowledge and complex clinical reasoning capabilities. Although large language models (LLMs) hold great potential for clinical reasoning, their high computational and memory requirements…

Computers and Society · Computer Science 2026-05-12 Xinchun Su , Chunxu Luo , Lipeng Ma , Yixuan Li , Weidong Yang

We introduce a novel large language model (LLM)-driven agent framework, which iteratively refines queries and filters contextual evidence by leveraging dynamically evolving knowledge. A defining feature of the system is its decoupling of…

Artificial Intelligence · Computer Science 2025-04-02 Seyoung Song

Doctors and patients alike increasingly use Large Language Models (LLMs) to diagnose clinical cases. However, unlike domains such as math or coding, where correctness can be objectively defined by the final answer, medical diagnosis…

Computation and Language · Computer Science 2025-05-21 Kevin Wu , Eric Wu , Rahul Thapa , Kevin Wei , Angela Zhang , Arvind Suresh , Jacqueline J. Tao , Min Woo Sun , Alejandro Lozano , James Zou

Physicians considering clinical trials for their patients are met with the laborious process of checking many text based eligibility criteria. Large Language Models (LLMs) have shown to perform well for clinical information extraction and…

Machine Learning · Computer Science 2023-06-30 Danny M. den Hamer , Perry Schoor , Tobias B. Polak , Daniel Kapitan

Interpretation is critical for disease diagnosis, but existing models struggle to balance predictive accuracy with human-understandable rationales. While large language models (LLMs) offer strong reasoning abilities, their clinical use is…

Computation and Language · Computer Science 2025-07-15 Shuai Niu , Jing Ma , Hongzhan Lin , Liang Bai , Zhihua Wang , Yida Xu , Yunya Song , Xian Yang

With the advancement of large language models, many dialogue systems are now capable of providing reasonable and informative responses to patients' medical conditions. However, when patients consult their doctor, they may experience…

Computation and Language · Computer Science 2025-06-17 Shang-Chi Tsai , Yun-Nung Chen

A major barrier towards the practical deployment of large language models (LLMs) is their lack of reliability. Three situations where this is particularly apparent are correctness, hallucinations when given unanswerable questions, and…

Computation and Language · Computer Science 2024-04-18 Christian Tomani , Kamalika Chaudhuri , Ivan Evtimov , Daniel Cremers , Mark Ibrahim

Retrieval-augmented generation (RAG) has shown impressive capabilities in mitigating hallucinations in large language models (LLMs). However, LLMs struggle to maintain consistent reasoning when exposed to misleading or conflicting evidence,…

Artificial Intelligence · Computer Science 2026-01-21 Linda Zeng , Rithwik Gupta , Divij Motwani , Yi Zhang , Diji Yang