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In response to the pressing need for advanced clinical problem-solving tools in healthcare, we introduce BooksMed, a novel framework based on a Large Language Model (LLM). BooksMed uniquely emulates human cognitive processes to deliver…

Continuing advances in Large Language Models (LLMs) in artificial intelligence offer important capacities in intuitively accessing and using medical knowledge in many contexts, including education and training as well as assessment and…

Computation and Language · Computer Science 2024-08-01 Roma Shusterman , Allison C. Waters , Shannon O`Neill , Phan Luu , Don M. Tucker

Large Language Models (LLMs) have shown strong potential in complex medical reasoning yet face diminishing gains under inference scaling laws. While existing studies augment LLMs with various knowledge types, it remains unclear how…

Artificial Intelligence · Computer Science 2026-02-10 Yu Zhao , Hao Guan , Yongcheng Jing , Ying Zhang , Dacheng Tao

Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical…

Computation and Language · Computer Science 2024-11-15 Nghia Trung Ngo , Chien Van Nguyen , Franck Dernoncourt , Thien Huu Nguyen

Electronic health records (EHRs) enable strong clinical prediction, but explanations are often coarse and hard to use for patient-level decisions. We propose a knowledge graph (KG)-guided chain-of-thought (CoT) framework for visit-level…

Artificial Intelligence · Computer Science 2026-03-03 Ruiyu Wang , Tuan Vinh , Ran Xu , Yuyin Zhou , Jiaying Lu , Carl Yang , Francisco Pasquel

Autonomous driving requires reliable reasoning over fine-grained 3D scene facts. Fine-grained question answering over multi-modal driving observations provides a natural way to evaluate this capability, yet existing perception pipelines and…

Artificial Intelligence · Computer Science 2026-03-24 Ye Tian , Jingyi Zhang , Zihao Wang , Xiaoyuan Ren , Xiaofan Yu , Onat Gungor , Tajana Rosing

Evidence-based medicine (EBM) holds a crucial role in clinical application. Given suitable medical articles, doctors effectively reduce the incidence of misdiagnoses. Researchers find it efficient to use large language models (LLMs)…

Computation and Language · Computer Science 2025-11-07 Mengzhou Sun , Sendong Zhao , Jianyu Chen , Haochun Wang , Bing Qin

Knowledge Graph (KG) contains entities and the relations between entities. Due to its representation ability, KG has been successfully applied to support many medical/healthcare tasks. However, in the medical domain, knowledge holds under…

Databases · Computer Science 2019-08-20 Yang Deng , Yaliang Li , Ying Shen , Nan Du , Wei Fan , Min Yang , Kai Lei

Providing knowledge documents for large language models (LLMs) has emerged as a promising solution to update the static knowledge inherent in their parameters. However, knowledge in the document may conflict with the memory of LLMs due to…

Computation and Language · Computer Science 2024-04-05 Yantao Liu , Zijun Yao , Xin Lv , Yuchen Fan , Shulin Cao , Jifan Yu , Lei Hou , Juanzi Li

The existing methods for evaluating the medical knowledge of Large Language Models (LLMs) are largely based on atemporal examination-style benchmarks, while in reality, medical knowledge is inherently dynamic and continuously evolves as new…

Machine Learning · Computer Science 2026-05-14 Zihan Guan , Qiao Jin , Guangzhi Xiong , Fangyuan Chen , Mengxuan Hu , Qingyu Chen , Yifan Peng , Zhiyong Lu , Anil Vullikanti

The rapid advancement of large language models (LLMs) has opened new boundaries in the extraction and synthesis of medical knowledge, particularly within evidence synthesis. This paper reviews the state-of-the-art applications of LLMs in…

The correct model response in the face of uncertainty is to abstain from answering a question so as not to mislead the user. In this work, we study the ability of LLMs to abstain from answering context-dependent science questions when…

Computation and Language · Computer Science 2024-10-08 Bingbing Wen , Bill Howe , Lucy Lu Wang

Continuous latent-space reasoning offers a compact alternative to textual chain-of-thought for multimodal models, enabling high-dimensional visual evidence to be integrated without explicit reasoning tokens. However, we identify a…

Machine Learning · Computer Science 2026-05-05 Xin Zhang , Qiqi Tao , Jiawei Du , Moyun Liu , Joey Tianyi Zhou

Knowledge Graph (KG) inductive reasoning, which aims to infer missing facts from new KGs that are not seen during training, has been widely adopted in various applications. One critical challenge of KG inductive reasoning is handling…

Artificial Intelligence · Computer Science 2024-06-21 Kai Wang , Yuwei Xu , Zhiyong Wu , Siqiang Luo

Here we present a holistic approach for data exploration on dense knowledge graphs as a novel approach with a proof-of-concept in biomedical research. Knowledge graphs are increasingly becoming a vital factor in knowledge mining and…

Artificial Intelligence · Computer Science 2019-12-16 Jens Dörpinghaus , Alexander Apke , Vanessa Lage-Rupprecht , Andreas Stefan

Large language models (LLMs) show promise for clinical use. They are often evaluated using datasets such as MedQA. However, Many medical datasets, such as MedQA, rely on simplified Question-Answering (Q\A) that underrepresents real-world…

Computation and Language · Computer Science 2025-10-24 Yunpeng Xiao , Carl Yang , Mark Mai , Xiao Hu , Kai Shu

Recently, Knowledge Graphs (KGs) have been successfully coupled with Large Language Models (LLMs) to mitigate their hallucinations and enhance their reasoning capability, such as in KG-based retrieval-augmented frameworks. However, current…

Artificial Intelligence · Computer Science 2024-10-22 Bo Ni , Yu Wang , Lu Cheng , Erik Blasch , Tyler Derr

The automatic construction of knowledge graphs (KGs) is an important research area in medicine, with far-reaching applications spanning drug discovery and clinical trial design. These applications hinge on the accurate identification of…

Computation and Language · Computer Science 2025-01-30 Vahan Arsenyan , Spartak Bughdaryan , Fadi Shaya , Kent Small , Davit Shahnazaryan

Extracting patient information from unstructured text is a critical task in health decision-support and clinical research. Large language models (LLMs) have shown the potential to accelerate clinical curation via few-shot in-context…

Computation and Language · Computer Science 2023-06-21 Zelalem Gero , Chandan Singh , Hao Cheng , Tristan Naumann , Michel Galley , Jianfeng Gao , Hoifung Poon

Knowledge graphs are widely used in industrial applications, making error detection crucial for ensuring the reliability of downstream applications. Existing error detection methods often fail to effectively utilize fine-grained subgraph…

Artificial Intelligence · Computer Science 2025-11-20 Yu Li , Yi Huang , Guilin Qi , Junlan Feng , Nan Hu , Songlin Zhai , Haohan Xue , Yongrui Chen , Ruoyan Shen , Tongtong Wu
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