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Encoding digital information into DNA sequences offers an attractive potential solution for storing rapidly growing data under the information age and the rise of artificial intelligence. However, practical implementations of DNA storage…

Information Theory · Computer Science 2026-01-26 Zimu Li , Bingyi Liu , Lei Zhao , Qian Zhang , Yang Liu , Jun Liu , Ke Ke , Huating Kong , Xiaolei Zuo , Chunhai Fan , Fei Wang

We present a family of additive quantum error-correcting codes whose capacities exceeds that of quantum random coding (hashing) for very noisy channels. These codes provide non-zero capacity in a depolarizing channel for fidelity parameters…

Quantum Physics · Physics 2009-10-30 David P. DiVincenzo , Peter W. Shor , John A. Smolin

The synthesis of DNA strands remains the most costly part of the DNA storage system. Thus, to make DNA storage system more practical, the time and materials used in the synthesis process have to be optimized. We consider the most common…

Information Theory · Computer Science 2023-05-15 Johan Chrisnata , Han Mao Kiah , Van Long Phuoc Pham

We consider a molecular channel, in which messages are encoded to the frequency of objects in a pool, and whose output during reading time is a noisy version of the input frequencies, as obtained by sampling with replacement from the pool.…

Information Theory · Computer Science 2025-04-28 Ran Tamir , Nir Weinberger

We develop several lower bounds on the capacity of binary input symmetric output channels with synchronization errors which also suffer from other types of impairments such as substitutions, erasures, additive white Gaussian noise (AWGN)…

Information Theory · Computer Science 2012-03-30 Mojtaba Rahmati , Tolga M. Duman

The rate regions of many variations of the standard and wire-tap channels have been thoroughly explored. Secrecy capacity characterizes the loss of rate required to ensure that the adversary gains no information about the transmissions.…

Information Theory · Computer Science 2018-06-27 Jake Perazzone , Eric Graves , Paul Yu , Rick Blum

Data storage in DNA is developing as a possible solution for archival digital data. Recently, to further increase the potential capacity of DNA-based data storage systems, the combinatorial composite DNA synthesis method was suggested. This…

Information Theory · Computer Science 2024-05-28 Omer Sabary , Inbal Preuss , Ryan Gabrys , Zohar Yakhini , Leon Anavy , Eitan Yaakobi

DNA Data storage has recently attracted much attention due to its durable preservation and extremely high information density (bits per gram) properties. In this work, we propose a hybrid coding strategy comprising of generalized…

Information Theory · Computer Science 2021-12-20 Yixin Wang , Li Deng , Md. Noor-A-Rahim , Erry Gunawan , Yong L. Guan , Zhi P. Shi , Chueh L. Poh

The process of DNA-based data storage (DNA storage for short) can be mathematically modelled as a communication channel, termed DNA storage channel, whose inputs and outputs are sets of unordered sequences. To design error correcting codes…

Information Theory · Computer Science 2020-06-11 Wentu Song , Kui Cai , Kees A. Schouhamer Immink

This paper introduces a new solution to DNA storage that integrates all three steps of retrieval, namely clustering, reconstruction, and error correction. DNA-correcting codes are presented as a unique solution to the problem of ensuring…

Information Theory · Computer Science 2024-07-02 Avital Boruchovsky , Daniella Bar-Lev , Eitan Yaakobi

DNA is a leading candidate as the next archival storage media due to its density, durability and sustainability. To read (and write) data DNA storage exploits technology that has been developed over decades to sequence naturally occurring…

Emerging Technologies · Computer Science 2022-05-12 Jasmine Quah , Omer Sella , Thomas Heinis

DNA data storage systems encode digital data into DNA strands, enabling dense and durable storage. Efficient data retrieval depends on coverage depth, a key performance metric. We study the random access coverage depth problem and focus on…

Information Theory · Computer Science 2025-07-29 Şeyma Bodur , Stefano Lia , Hiram H. López , Rati Ludhani , Alberto Ravagnani , Lisa Seccia

Nanopore sequencing is an emerging DNA sequencing technology that has been proposed for use in DNA storage systems. We propose the noisy nanopore channel model for nanopore sequencing. This model captures duplications, inter-symbol…

Information Theory · Computer Science 2022-05-10 Brendon McBain , Emanuele Viterbo , James Saunderson

In [1], the authors proposed a new model of DNA storage system that integrates all three steps of retrieval and introduced the concept of DNA-correcting codes, which guarantees that the output of the storage system can be decoded to the…

Information Theory · Computer Science 2023-11-17 Huawei Wu

Over the past years, the ever-growing trend on data storage demand, more specifically for "cold" data (rarely accessed data), has motivated research for alternative systems of data storage. Because of its biochemical characteristics,…

Machine Learning · Computer Science 2022-03-21 Xavier Pic , Marc Antonini

The biochemical processes underlying DNA data storage, including synthesis, amplification, and sequencing, are inherently noisy. Consequently, base-level insertion, deletion, and substitution (IDS) errors, as well as sequence-level…

Information Theory · Computer Science 2026-03-17 Ramy Khabbaz , Jérémy Mateos , Marc Antonini , Serge Kas Hanna

Machine learning techniques are increasingly being used in fundamental research to solve various challenging problems. Here we explore one such technique to address an important problem in quantum communication scenario. While transferring…

Quantum Physics · Physics 2022-09-27 Govind Lal Sidhardh , Mir Alimuddin , Manik Banik

In analogy with its classical counterpart, a noisy quantum channel is characterized by a loss, a quantity that depends on the channel input and the quantum operation performed by the channel. The loss reflects the transmission quality: if…

Quantum Physics · Physics 2011-07-19 Nicolas J. Cerf

Recent studies on the memorization effects of deep neural networks on noisy labels show that the networks first fit the correctly-labeled training samples before memorizing the mislabeled samples. Motivated by this early-learning…

Machine Learning · Computer Science 2021-09-07 Yangdi Lu , Yang Bo , Wenbo He

DNA is an attractive candidate for data storage. Its millennial durability and nanometer scale offer exceptional data density and longevity. Its relevance to medical applications also drives advances in DNA-related biotechnology. To protect…

Information Theory · Computer Science 2025-11-25 Yu-Ting Lin , Hsin-Po Wang , Venkatesan Guruswami
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