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Related papers: SpecMER: Fast Protein Generation with K-mer Guided…

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Speculative generation has emerged as a promising technique to accelerate inference in large language models (LLMs) by leveraging parallelism to verify multiple draft tokens simultaneously. However, the fundamental limits on the achievable…

Computation and Language · Computer Science 2025-12-15 Sergey Pankratov , Dan Alistarh

Rollout dominates the training time in large language model (LLM) post-training, where the trained model is used to generate tokens given a batch of prompts. This work, SpecActor, achieves fast rollout with speculative decoding that deploys…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-24 Rongxin Cheng , Kai Zhou , Xingda Wei , Siyuan Liu , Mingcong Han , Mingjing Ai , Yeju Zhou , Baoquan Zhong , Wencong Xiao , Rong Chen , Haibo Chen

Speculative Decoding (SD) accelerates autoregressive large language model (LLM) inference by decoupling generation and verification. While recent methods improve draft quality by tightly coupling the drafter with the target model, the…

Machine Learning · Computer Science 2026-04-14 Jingwei Song , Xinyu Wang , Hanbin Wang , Xiaoxuan Lei , Bill Shi , Shixin Han , Eric Yang , Xiao-Wen Chang , Lynn Ai

Machine-learning models that learn from data to predict how protein sequence encodes function are emerging as a useful protein engineering tool. However, when using these models to suggest new protein designs, one must deal with the vast…

Quantitative Methods · Quantitative Biology 2021-07-07 Brian L. Hie , Kevin K. Yang

Speculative decoding accelerates Large Language Model inference via a draft-then-verify paradigm, yet the output projection layer becomes a bottleneck as vocabulary sizes scale. While existing static pruning methods effectively reduce this…

Computation and Language · Computer Science 2026-05-29 Shuyu Zhang , Lingfeng Pan , Qicheng Wang , Yaqi Shi , Yueyang Tan , Ruyu Yan , Jiaqi Chen , Lixing Du , Lu Wang

Speculative decoding (SD) accelerates Large Language Model (LLM) generation by using an efficient draft model to propose the next few tokens, which are verified by the LLM in a single forward call, reducing latency while preserving its…

Computation and Language · Computer Science 2025-05-30 Milan Gritta , Huiyin Xue , Gerasimos Lampouras

Tokenization is a promising path to multi-modal models capable of jointly understanding protein sequences, structure, and function. Existing protein structure tokenizers create tokens by pooling information from local neighborhoods, an…

Machine Learning · Computer Science 2026-02-09 Rohit Dilip , Ayush Varshney , David Van Valen

Speculative decoding has been widely used to accelerate auto-regressive (AR) text generation. However, its effectiveness for visual AR models remains limited due to token selection ambiguity, where multiple tokens share similarly low…

Computer Vision and Pattern Recognition · Computer Science 2025-03-28 Sihwan Park , Doohyuk Jang , Sungyub Kim , Souvik Kundu , Eunho Yang

Representation learning and \emph{de novo} generation of proteins are pivotal computational biology tasks. Whilst natural language processing (NLP) techniques have proven highly effective for protein sequence modelling, structure modelling…

Quantitative Methods · Quantitative Biology 2025-01-08 Benoit Gaujac , Jérémie Donà , Liviu Copoiu , Timothy Atkinson , Thomas Pierrot , Thomas D. Barrett

Speculative decoding is a technique that uses multiple language models to accelerate infer- ence. Previous works have used an experi- mental approach to optimize the throughput of the inference pipeline, which involves LLM training and can…

Computation and Language · Computer Science 2026-03-13 Amirhossein Bozorgkhoo , Igor Molybog

Speculative decoding has emerged as a pivotal technique to accelerate LLM inference by employing a lightweight draft model to generate candidate tokens that are subsequently verified by the target model in parallel. However, while this…

Computation and Language · Computer Science 2026-02-26 Yuetao Chen , Xuliang Wang , Xinzhou Zheng , Ming Li , Peng Wang , Hong Xu

Proteins play essential roles in nature, from catalyzing biochemical reactions to binding specific targets. Advances in protein engineering have the potential to revolutionize biotechnology and healthcare by designing proteins with tailored…

Biomolecules · Quantitative Biology 2025-05-05 Hocheol Lim , Geon-Ho Lee , Kyoung Tai No

Speculative Decoding (SD) has emerged as a critical technique for accelerating Large Language Model (LLM) inference. Unlike deterministic system optimizations, SD performance is inherently data-dependent, meaning that diverse and…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-29 Talor Abramovich , Maor Ashkenazi , Izzy Putterman , Benjamin Chislett , Tiyasa Mitra , Bita Darvish Rouhani , Ran Zilberstein , Yonatan Geifman

Speculative decoding is a promising approach for accelerating large language models. The primary idea is to use a lightweight draft model to speculate the output of the target model for multiple subsequent timesteps, and then verify them in…

Computation and Language · Computer Science 2025-11-06 Yepeng Weng , Qiao Hu , Xujie Chen , Li Liu , Dianwen Mei , Huishi Qiu , Jiang Tian , Zhongchao Shi

Speculative decoding accelerates large language model inference using a smaller draft model. In this paper, we establish a surprising connection between speculative decoding and channel simulation, which aims at simulating a noisy channel…

Computation and Language · Computer Science 2025-04-23 Szymon Kobus , Deniz Gündüz

We introduce PARSE (PArallel pRefix Speculative Engine), a speculative generation framework that accelerates large language model (LLM) inference by parallelizing prefix verification on a semantic level. Existing speculative decoding…

Artificial Intelligence · Computer Science 2026-05-07 Yuncheng Yao , Yuxuan Xia , Shengjie Wang , Danyang Zhuo

Self-speculative decoding (SSD) accelerates LLM inference by skipping layers to create an efficient draft model, yet existing methods often rely on static heuristics that ignore the dynamic computational overhead of attention in…

Machine Learning · Computer Science 2026-02-25 Seongjin Cha , Gyuwan Kim , Dongsu Han , Tao Yang , Insu Han

The design of novel protein sequences with targeted functionalities underpins a central theme in protein engineering, impacting diverse fields such as drug discovery and enzymatic engineering. However, navigating this vast combinatorial…

Biomolecules · Quantitative Biology 2024-02-19 Yiheng Zhu , Zitai Kong , Jialu Wu , Weize Liu , Yuqiang Han , Mingze Yin , Hongxia Xu , Chang-Yu Hsieh , Tingjun Hou

Spider silks are remarkable materials characterized by superb mechanical properties such as strength, extensibility and lightweightedness. Yet, to date, limited models are available to fully explore sequence-property relationships for…

Materials Science · Physics 2023-10-20 Wei Lu , David L. Kaplan , Markus J. Buehler

Large Language Models (LLMs) increasingly rely on reinforcement learning with verifiable rewards (RLVR) to elicit reliable chain-of-thought reasoning. However, the training process remains bottlenecked by the computationally expensive…

Machine Learning · Computer Science 2026-01-13 Bingshuai Liu , Ante Wang , Zijun Min , Liang Yao , Haibo Zhang , Yang Liu , Xu Han , Peng Li , Anxiang Zeng , Jinsong Su
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