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Related papers: SpecMER: Fast Protein Generation with K-mer Guided…

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Speculative Decoding (SD) is a widely used approach to accelerate the inference of large language models (LLMs) without reducing generation quality. It operates by first using a compact model to draft multiple tokens efficiently, followed…

Computation and Language · Computer Science 2025-08-08 Hossein Entezari Zarch , Lei Gao , Chaoyi Jiang , Murali Annavaram

Speculative decoding (SPD) accelerates large language model (LLM) inference by letting a smaller draft model propose multiple future tokens that are verified in parallel by a larger target model. The dominant SPD paradigm treats the target…

Computation and Language · Computer Science 2026-05-26 Jinze Li , Yixing Xu , Guanchen Li , Jinfeng Xu , Shuo Yang , Yang Zhang , Xuanwu Yin , Dong Li , Edith C. H. Ngai , Emad Barsoum

Efficient inference in large language models (LLMs) has become a critical focus as their scale and complexity grow. Traditional autoregressive decoding, while effective, suffers from computational inefficiencies due to its sequential token…

Computation and Language · Computer Science 2024-11-28 Hyun Ryu , Eric Kim

Designing protein sequences that fold into a target 3D structure, known as protein inverse folding, is a fundamental challenge in protein engineering. While recent deep learning methods have achieved impressive performance by recovering…

Biomolecules · Quantitative Biology 2025-06-03 Mengdi Liu , Xiaoxue Cheng , Zhangyang Gao , Hong Chang , Cheng Tan , Shiguang Shan , Xilin Chen

This technical report describes the design and training of novel speculative decoding draft models, for accelerating the inference speeds of large language models in a production environment. By conditioning draft predictions on both…

Computation and Language · Computer Science 2024-06-10 Davis Wertheimer , Joshua Rosenkranz , Thomas Parnell , Sahil Suneja , Pavithra Ranganathan , Raghu Ganti , Mudhakar Srivatsa

Much scientific enquiry across disciplines is founded upon a mechanistic treatment of dynamic systems that ties form to function. A highly visible instance of this is in molecular biology, where an important goal is to determine…

Biomolecules · Quantitative Biology 2021-06-17 Xiaojie Guo , Yuanqi Du , Sivani Tadepalli , Liang Zhao , Amarda Shehu

Deep learning approaches have produced substantial breakthroughs in fields such as image classification and natural language processing and are making rapid inroads in the area of protein design. Many generative models of proteins have been…

Machine Learning · Computer Science 2021-09-29 Alexey Strokach , Philip M. Kim

The design of protein sequences with desired functionalities is a fundamental task in protein engineering. Deep generative methods, such as autoregressive models and diffusion models, have greatly accelerated the discovery of novel protein…

Machine Learning · Computer Science 2025-04-16 Zitai Kong , Yiheng Zhu , Yinlong Xu , Hanjing Zhou , Mingzhe Yin , Jialu Wu , Hongxia Xu , Chang-Yu Hsieh , Tingjun Hou , Jian Wu

Generative recommendation (GR) is an emerging paradigm that tokenizes items into discrete tokens and learns to autoregressively generate the next tokens as predictions. While this token-generation paradigm is expected to surpass traditional…

Information Retrieval · Computer Science 2025-11-25 Yijie Ding , Jiacheng Li , Julian McAuley , Yupeng Hou

Generative modeling has become a central paradigm in protein research, extending machine learning beyond structure prediction toward sequence design, backbone generation, inverse folding, and biomolecular interaction modeling. However, the…

Machine Learning · Computer Science 2026-03-30 Senura Hansaja Wanasekara , Minh-Duong Nguyen , Xiaochen Liu , Nguyen H. Tran , Ken-Tye Yong

Speculative decoding is an effective and lossless method for Large Language Model (LLM) inference acceleration. It employs a smaller model to generate a draft token sequence, which is then verified by the original base model. In multi-GPU…

Machine Learning · Computer Science 2025-12-09 Yize Wu , Ke Gao , Ling Li , Yanjun Wu

Speculative decoding accelerates LLM inference by drafting multiple tokens and verifying them in parallel with the target model. However, its practical speedup is constrained by the trade-off between draft quality and drafting cost:…

Computation and Language · Computer Science 2026-05-29 Jianuo Huang , Yaojie Zhang , Qituan Zhang , Hao Lin , Hanlin Xu , Linfeng Zhang

Large language models (LLMs) have revolutionized natural language processing and broadened their applicability across diverse commercial applications. However, the deployment of these models is constrained by high inference time in…

Computation and Language · Computer Science 2024-11-12 Euiin Yi , Taehyeon Kim , Hongseok Jeung , Du-Seong Chang , Se-Young Yun

Speculative decoding (SD) has emerged as a powerful method for accelerating autoregressive generation in large language models (LLMs), yet its integration into vision-language models (VLMs) remains underexplored. We introduce DREAM, a novel…

Computation and Language · Computer Science 2025-10-24 Yunhai Hu , Tianhua Xia , Zining Liu , Rahul Raman , Xingyu Liu , Bo Bao , Eric Sather , Vithursan Thangarasa , Sai Qian Zhang

Recent advances in inference-time compute have significantly improved performance on complex tasks by generating long chains of thought (CoTs) using Large Reasoning Models (LRMs). However, this improved accuracy comes at the cost of high…

Machine Learning · Computer Science 2025-05-20 Rui Pan , Yinwei Dai , Zhihao Zhang , Gabriele Oliaro , Zhihao Jia , Ravi Netravali

Speculative decoding (SD) is a widely used approach for accelerating decode-heavy LLM inference workloads. While online inference workloads are highly dynamic, existing SD systems are rigid and take a coarse-grained approach to SD…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-23 Wenyan Chen , Chengzhi Lu , Yanying Lin , Dmitrii Ustiugov

Autoregressive sequence models based on deep neural networks, such as RNNs, Wavenet and the Transformer attain state-of-the-art results on many tasks. However, they are difficult to parallelize and are thus slow at processing long…

Machine Learning · Computer Science 2018-06-11 Łukasz Kaiser , Aurko Roy , Ashish Vaswani , Niki Parmar , Samy Bengio , Jakob Uszkoreit , Noam Shazeer

Speculative Decoding (SD) is a technique to accelerate the inference of Large Language Models (LLMs) by using a lower complexity draft model to propose candidate tokens verified by a larger target model. To further improve efficiency,…

Computation and Language · Computer Science 2024-12-17 Xiaofan Lu , Yixiao Zeng , Feiyang Ma , Zixu Yu , Marco Levorato

Speculative Decoding (SD) has emerged as a widely used paradigm to accelerate the inference of large language models (LLMs) without compromising generation quality. It works by efficiently drafting multiple tokens using a compact model and…

Computation and Language · Computer Science 2026-01-21 Mingbo Song , Heming Xia , Jun Zhang , Chak Tou Leong , Qiancheng Xu , Wenjie Li , Sujian Li

Self-speculative decoding is an inference technique for large language models designed to speed up generation without sacrificing output quality. It combines fast, approximate decoding using a compact version of the model as a draft model…

Machine Learning · Computer Science 2026-04-17 Walaa Amer , Uday das , Fadi Kurdahi
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