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Inference efficiency in Large Language Models (LLMs) is fundamentally limited by their serial, autoregressive generation, especially as reasoning becomes a key capability and response sequences grow longer. Speculative decoding (SD) offers…

Machine Learning · Computer Science 2026-02-02 Haoyun Jiang , Junqi He , Feng Hong , Xinlong Yang , Jianwei Zhang , Zheng Li , Zhengyang Zhuge , Zhiyong Chen , Bo Han , Junyang Lin , Jiangchao Yao

Generative protein language models are a natural way to design new proteins with desired functions. However, current models are either difficult to direct to produce a protein from a specific family of interest, or must be trained on a…

Quantitative Methods · Quantitative Biology 2024-01-08 Timothy F. Truong , Tristan Bepler

Generating protein sequences that fold into a intended 3D structure is a fundamental step in de novo protein design. De facto methods utilize autoregressive generation, but this eschews higher order interactions that could be exploited to…

Biomolecules · Quantitative Biology 2023-12-06 John J. Yang , Jason Yim , Regina Barzilay , Tommi Jaakkola

Deep autoregressive sequence-to-sequence models have demonstrated impressive performance across a wide variety of tasks in recent years. While common architecture classes such as recurrent, convolutional, and self-attention networks make…

Machine Learning · Computer Science 2018-11-09 Mitchell Stern , Noam Shazeer , Jakob Uszkoreit

The ability to accurately model the fitness landscape of protein sequences is critical to a wide range of applications, from quantifying the effects of human variants on disease likelihood, to predicting immune-escape mutations in viruses…

Machine Learning · Computer Science 2022-05-30 Pascal Notin , Mafalda Dias , Jonathan Frazer , Javier Marchena-Hurtado , Aidan Gomez , Debora S. Marks , Yarin Gal

Speculative decoding is an effective technique for accelerating large language model inference by drafting multiple tokens in parallel. In practice, its speedup is often bottlenecked by a rigid verification step that strictly enforces the…

Computation and Language · Computer Science 2026-04-10 Ziyi Wang , Siva Rajesh Kasa , Ankith M S , Santhosh Kumar Kasa , Jiaru Zou , Sumit Negi , Ruqi Zhang , Nan Jiang , Qifan Song

Generative models in molecular design tend to be richly parameterized, data-hungry neural models, as they must create complex structured objects as outputs. Estimating such models from data may be challenging due to the lack of sufficient…

Machine Learning · Computer Science 2021-08-17 Kevin Yang , Wengong Jin , Kyle Swanson , Regina Barzilay , Tommi Jaakkola

Speculative Decoding has gained popularity as an effective technique for accelerating the auto-regressive inference process of Large Language Models. However, Speculative Decoding entirely relies on the availability of efficient draft…

Computation and Language · Computer Science 2025-06-06 Ofir Zafrir , Igor Margulis , Dorin Shteyman , Shira Guskin , Guy Boudoukh

Speculative decoding accelerates LLM inference by using a smaller draft model to speculate tokens that a larger target model verifies. Verification is often the bottleneck (e.g. verification is $4\times$ slower than token generation when a…

Computation and Language · Computer Science 2026-05-27 Avinash Kumar , Sujay Sanghavi , Poulami Das

Speculative sampling has emerged as an important technique for accelerating the auto-regressive generation process of large language models (LLMs) by utilizing a draft-then-verify mechanism to produce multiple tokens per forward pass. While…

Computation and Language · Computer Science 2025-03-12 Weilin Zhao , Tengyu Pan , Xu Han , Yudi Zhang , Ao Sun , Yuxiang Huang , Kaihuo Zhang , Weilun Zhao , Yuxuan Li , Jianyong Wang , Zhiyuan Liu , Maosong Sun

As large language models gain widespread adoption, running them efficiently becomes crucial. Recent works on LLM inference use speculative decoding to achieve extreme speedups. However, most of these works implicitly design their algorithms…

Computation and Language · Computer Science 2024-12-03 Ruslan Svirschevski , Avner May , Zhuoming Chen , Beidi Chen , Zhihao Jia , Max Ryabinin

Speculative decoding (SD) accelerates LLM inference by verifying draft tokens in parallel. However, this method presents a critical trade-off: it improves throughput in low-load, memory-bound systems but degrades performance in high-load,…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-04 Rui Li , Zhaoning Zhang , Libo Zhang , Huaimin Wang , Xiang Fu , Zhiquan Lai

Autoregressive video diffusion is emerging as a promising paradigm for streaming video synthesis, with step distillation serving as the primary means of accelerating inference. Whether speculative decoding, the dominant acceleration…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Yuezhou Hu , Jintao Zhang

Score-based generative models (SGMs) have proven to be powerful tools for designing new proteins. Designing proteins that bind a pre-specified target is highly relevant to a range of medical and industrial applications. Despite the flurry…

Biomolecules · Quantitative Biology 2024-09-30 John D Boom , Matthew Greenig , Pietro Sormanni , Pietro Liò

Low-latency decoding for large language models (LLMs) is crucial for applications like chatbots and code assistants, yet generating long outputs remains slow in single-query settings. Prior work on speculative decoding (which combines a…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-06-16 Ziyi Zhang , Ziheng Jiang , Chengquan Jiang , Menghan Yu , Size Zheng , Haibin Lin , Henry Hoffmann , Xin Liu

Large language models (LLMs) exhibit exceptional performance across a wide range of tasks; however, their token-by-token autoregressive generation process significantly hinders inference speed. Speculative decoding presents a promising…

Computation and Language · Computer Science 2025-03-04 Kai Lv , Honglin Guo , Qipeng Guo , Xipeng Qiu

Existing large language models have to run K times to generate a sequence of K tokens. In this paper, we present RecycleGPT, a generative language model with fast decoding speed by recycling pre-generated model states without running the…

Computation and Language · Computer Science 2024-05-24 Yufan Jiang , Qiaozhi He , Xiaomin Zhuang , Zhihua Wu , Kunpeng Wang , Wenlai Zhao , Guangwen Yang

This paper demonstrates that language models are strong structure-based protein designers. We present LM-Design, a generic approach to reprogramming sequence-based protein language models (pLMs), that have learned massive sequential…

Machine Learning · Computer Science 2023-02-10 Zaixiang Zheng , Yifan Deng , Dongyu Xue , Yi Zhou , Fei YE , Quanquan Gu

Large language models (LLMs) have shown outstanding performance across numerous real-world tasks. However, the autoregressive nature of these models makes the inference process slow and costly. Speculative decoding has emerged as a…

Artificial Intelligence · Computer Science 2025-03-17 Zongyue Qin , Zifan He , Neha Prakriya , Jason Cong , Yizhou Sun

There has been a lot of recent interest in designing neural network models to estimate a distribution from a set of examples. We introduce a simple modification for autoencoder neural networks that yields powerful generative models. Our…

Machine Learning · Computer Science 2015-06-08 Mathieu Germain , Karol Gregor , Iain Murray , Hugo Larochelle