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Purpose:The recently proposed IPO-IMPT framework allows simultaneous optimization of dose, dose rate, and LET for FLASH treatment planning. Finding solutions to IPO-IMPT is difficult due to computational intensiveness. Nevertheless, an…

Objective: Proton spot-scanning arc therapy (ARC) is an emerging modality that can improve the high-dose conformity to targets compared with standard intensity-modulated proton therapy (IMPT). However, the efficient treatment delivery of…

FLASH is a new treatment modality that requires optimization of dose, dose rate, and LET. Here we validate these three quantities under FLASH conditions, which includes the quantum uncertainty in the time-dependent instantaneous dose rate…

High-quality proton beams generated by laser-plasma interactions are of significant interest for applications ranging from tumor therapy to fast ignition in inertial confinement fusion. However, simultaneously achieving high energy coupling…

Plasma Physics · Physics 2026-03-17 Cheng-Qi Zhang , Yang He , Mamat Ali Bake , Bai-Song Xie

This work details a highly efficient implementation of the 3D scale-invariant feature transform (SIFT) algorithm, for the purpose of machine learning from large sets of volumetric medical image data. The primary operations of the 3D SIFT…

Computer Vision and Pattern Recognition · Computer Science 2021-12-21 Jean-Baptiste Carluer , Laurent Chauvin , Jie Luo , William M. Wells , Ines Machado , Rola Harmouche , Matthew Toews

Advancements in AI have greatly enhanced the medical imaging process, making it quicker to diagnose patients. However, very few have investigated the optimization of a multi-model system with hardware acceleration. As specialized edge…

Hardware Architecture · Computer Science 2025-10-03 Ashiyana Abdul Majeed , Mahmoud Meribout , Safa Mohammed Sali

We present an improvement of our implementation of the Correlation Technique for the Fourier Domain Acceleration Search (FDAS) algorithm on Graphics Processor Units (GPUs) (Dimoudi & Armour 2015; Dimoudi et al. 2017). Our new improved…

Instrumentation and Methods for Astrophysics · Physics 2017-11-30 Karel Adámek , Sofia Dimoudi , Mike Giles , Wesley Armour

In recent years, free energy perturbation (FEP) calculations have garnered increasing attention as tools to support drug discovery. The lead optimization mapper (Lomap) was proposed as an algorithm to calculate the relative free energy…

Biomolecules · Quantitative Biology 2023-04-11 Kairi Furui , Masahito Ohue

Purpose: To provide a fast computational method, based on the proximal graph solver (POGS) - a convex optimization solver using the alternating direction method of multipliers (ADMM), for calculating an optimal treatment plan in rotating…

Medical Physics · Physics 2018-02-07 Myung Cho , Xiaodong Wu , Hossein Dakhah , Jirong Yi , Ryan T. Flynn , Yusung Kim , Weiyu Xu

While Model Predictive Control (MPC) delivers strong performance across robotics applications, solving the underlying (batches of) nonlinear trajectory optimization (TO) problems online remains computationally demanding. Existing…

Robotics · Computer Science 2026-05-11 Alexander Du , Emre Adabag , Gabriel Bravo-Palacios , Brian Plancher

Fabry-P\'erot based photoacoustic tomography (FP-PAT) is a promising all-optical imaging modality for a wide range of preclinical and clinical applications. However, there exist several challenges in routinely applying FP-PAT in…

Optics · Physics 2025-12-01 Jakub Czuchnowski , Robert Prevedel

Large language models (LLMs) have revolutionized AI applications, yet their enormous computational demands severely limit deployment and real-time performance. Quantization methods can help reduce computational costs, however, attaining the…

Machine Learning · Computer Science 2025-09-03 Shaobo Ma , Chao Fang , Haikuo Shao , Zhongfeng Wang

Achieving high performance for GPU codes requires developers to have significant knowledge in parallel programming and GPU architectures, and in-depth understanding of the application. This combination makes it challenging to find…

Software Engineering · Computer Science 2022-08-29 Jhe-Yu Liou , Muaaz Awan , Steven Hofmeyr , Stephanie Forrest , Carole-Jean Wu

Metaheuristic algorithms are widely used for solving complex problems due to their ability to provide near-optimal solutions. But the execution time of these algorithms increases with the problem size and/or solution space. And, to get more…

Neural and Evolutionary Computing · Computer Science 2025-12-16 Henish Soliya , Anugrah Jain

Statistical iterative reconstruction is expected to improve the image quality of megavoltage computed tomography (MVCT). However, one of the challenges of iterative reconstruction is its large computational cost. The purpose of this work is…

Compact, stable, and versatile laser-driven ion sources hold great promise for applications ranging from medicine to materials science and fundamental physics. While single-shot sources have demonstrated favorable beam properties, including…

In drug discovery, molecular docking aims at characterizing the binding of a drug-like molecule to a macromolecule. AutoDock-GPU, a state-of-the-art docking software, estimates the geometrical conformation of a docked ligand-protein complex…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-10-15 Gabin Schieffer , Ivy Peng

Uncompressed clinical data from modern positron emission tomography (PET) scanners are very large, exceeding 350 million data points (projection bins). The last decades have seen tremendous advancements in mathematical imaging tools many of…

Medical Physics · Physics 2020-01-08 Matthias J. Ehrhardt , Pawel Markiewicz , Carola-Bibiane Schönlieb

Radiotherapy (RT) planning is complex, subjective, and time-intensive. Advances with artificial intelligence (AI) promise to improve its precision and efficiency, but progress is often limited by the scarcity of large, standardized…

X-ray imaging dose from serial cone-beam CT (CBCT) scans raises a clinical concern in most image guided radiation therapy procedures. It is the goal of this paper to develop a fast GPU-based algorithm to reconstruct high quality CBCT images…

Medical Physics · Physics 2015-05-19 Xun Jia , Bin Dong , Yifei Lou , Steve B. Jiang
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