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A target composition scheme to optimize the combined proton acceleration regime is presented and verified by two-dimensional particle-in-cell (2D PIC) simulations by using an ultra-intense circularly-polarized (CP) laser pulse irradiating…

Plasma Physics · Physics 2016-02-17 W. P. Yao , B. W. Li , C. Y. Zheng , Z. J. Liu , X. Q. Yan

Objective: Radiotherapy treatment planning is a time-consuming and potentially subjective process that requires the iterative adjustment of model parameters to balance multiple conflicting objectives. Recent advancements in frontier…

Speeding up the large-scale distributed training is challenging in that it requires improving various components of training including load balancing, communication, optimizers, etc. We present novel approaches for fast large-scale training…

Purpose: The presence of respiratory motion during radiation treatment leads to degradation of the expected dose distribution, both for target coverage and healthy-tissue sparing, particularly for techniques like pencil-beam scanning proton…

We present a massively parallel Lagrange decomposition method for solving 0--1 integer linear programs occurring in structured prediction. We propose a new iterative update scheme for solving the Lagrangean dual and a perturbation technique…

Optimization and Control · Mathematics 2022-04-20 Ahmed Abbas , Paul Swoboda

Proton therapy is a modality in fast development. Characterized by a maximum dose deposition at the end of the proton trajectory followed by a sharp fall-off, proton beams can deliver a highly conformal dose to the tumor while sparing…

Medical Physics · Physics 2022-05-18 François Smekens , Nicolas Freud , Bruno Sixou , Guillaume Beslon , Jean M Létang

With growing deployment of Internet of Things (IoT) and machine learning (ML) applications, which need to leverage computation on edge and cloud resources, it is important to develop algorithms and tools to place these distributed…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-12-30 Xiangchen Zhao , Diyi Hu , Bhaskar Krishnamachari

In this paper, we presented an efficient algorithm to implement the regularization reconstruction of SPECT. Image reconstruction with priori assumptions is usually modeled as a constrained optimization problem. However, there is no…

Optimization and Control · Mathematics 2013-06-07 Shousheng Luo , Tie Zhou

Combinatorial optimization problems arise in logistics, scheduling, and resource allocation, yet existing approaches face a fundamental trade-off among generality, performance, and usability. We present cuGenOpt, a GPU-accelerated…

Artificial Intelligence · Computer Science 2026-03-20 Yuyang Liu

We introduce a fusion of GPU accelerated primal heuristics for Mixed Integer Programming. Leveraging GPU acceleration enables exploration of larger search regions and faster iterations. A GPU-accelerated PDLP serves as an approximate LP…

Optimization and Control · Mathematics 2025-10-31 Akif Çördük , Piotr Sielski , Alice Boucher , Kumar Aatish

FFT (fast Fourier transform) plays a very important role in many fields, such as digital signal processing, digital image processing and so on. However, in application, FFT becomes a factor of affecting the processing efficiency, especially…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-07-25 Fan Zhang , Chen Hu , Qiang Yin , Wei Hu

Purpose: Respiratory motion and the interplay effect cause the dose delivered to a patient with spot-scanned proton therapy to differ from the dose planned for during optimization. A new 4D robust optimization methodology was developed…

Purpose: To develop a novel aperture-based algorithm for volumetric modulated arc therapy (VMAT) treatment plan optimization with high quality and high efficiency. Methods: The VMAT optimization problem is formulated as a large-scale convex…

Medical Physics · Physics 2015-05-19 Chunhua Men , H. Edwin Romeijn , Xun Jia , Steve B. Jiang

This paper presents a GPU-accelerated computational framework for reconstructing high resolution (HR) LF images under a mixed Gaussian-Impulse noise condition. The main focus is on developing a high-performance approach considering…

Image and Video Processing · Electrical Eng. & Systems 2022-06-13 Trung-Hieu Tran , Kaicong Sun , Sven Simon

[18F]FDG-PET/CT is a cornerstone imaging modality for tumor staging and treatment response assessment across many cancer types, yet expert reader shortages necessitate more efficient diagnostic aids. While standalone AI models for automatic…

Purpose: Historically, spot scanning proton therapy (SSPT) treatment planning utilizes dose volume constraints and linear-energy-transfer (LET) volume constraints separately to balance tumor control and organs-at-risk (OARs) protection. We…

Dataset deduplication is widely recognized as a crucial preprocessing step that enhances data quality and improves the performance of large language models. A commonly used method for this process is the MinHash Locality-Sensitive Hashing…

Computation and Language · Computer Science 2026-05-19 Youngjun Son , Chaewon Kim , Jaejin Lee

Spatiotemporal fractionation schemes, that is, treatments delivering different dose distributions in different fractions, may lower treatment side effects without compromising tumor control. This is achieved by hypofractionating parts of…

Medical Physics · Physics 2018-02-14 Melissa R. Gaddy , Sercan Yıldız , Jan Unkelbach , Dávid Papp

The optimisation of fed-batch (bio)chemical process recipes is subject to inherent, underlying, and unmeasurable fluctuations across batches, whose trajectories are difficult to model and costly to measure. Bayesian Optimisation (BayesOpt)…

We present the barycentric Lagrange dual tree traversal (BLDTT) fast summation method for particle interactions. The scheme replaces well-separated particle-particle interactions by adaptively chosen particle-cluster, cluster-particle, and…

Computational Physics · Physics 2021-06-02 Leighton Wilson , Nathan Vaughn , Robert Krasny