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We introduce ProtoPathway, an interpretable-by-design multimodal framework for cancer survival prediction that unifies whole slide imaging and transcriptomics through encoders producing biologically grounded representations on both sides of…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Amaya Gallagher-Syed , Costantino Pitzalis , Myles J. Lewis , Michael R. Barnes , Gregory Slabaugh

While some convolutional neural networks (CNNs) have achieved great success in object recognition, they struggle to identify objects in images corrupted with different types of common noise patterns. Recently, it was shown that simulating…

Computer Vision and Pattern Recognition · Computer Science 2023-10-17 Ruxandra Barbulescu , Tiago Marques , Arlindo L. Oliveira

Foundation models like CLIP and SAM have advanced computer vision and medical imaging via low-shot transfer learning, aiding CADD with limited data. However, their deployment faces two key challenges. \textit{distribution shift} where…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Behraj Khan , Tahir Qasim Syed , Nouman M. Durrani , Bilal Naseem , Shabir Ahmad , Rizwan Qureshi

Representation learning of pathology whole-slide images (WSIs) has primarily relied on weak supervision with Multiple Instance Learning (MIL). This approach leads to slide representations highly tailored to a specific clinical task.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Tim Lenz , Peter Neidlinger , Marta Ligero , Georg Wölflein , Marko van Treeck , Jakob Nikolas Kather

Foundation models provide robust embeddings for diverse tasks, including medical imaging. We evaluate embeddings from seven general and medical-specific foundation models (e.g., DenseNet121, BiomedCLIP, MedImageInsight, Rad-DINO,…

Artificial intelligence has started to transform histopathology impacting clinical diagnostics and biomedical research. However, while many computational pathology approaches have been proposed, most current AI models are limited with…

This paper investigates contextual word representation models from the lens of similarity analysis. Given a collection of trained models, we measure the similarity of their internal representations and attention. Critically, these models…

Computation and Language · Computer Science 2020-05-05 John M. Wu , Yonatan Belinkov , Hassan Sajjad , Nadir Durrani , Fahim Dalvi , James Glass

In this work, we perform an in-depth analysis of the visualisation methods implemented in two popular self-explaining models for visual classification based on prototypes - ProtoPNet and ProtoTree. Using two fine-grained datasets…

Computer Vision and Pattern Recognition · Computer Science 2023-05-16 Romain Xu-Darme , Georges Quénot , Zakaria Chihani , Marie-Christine Rousset

Advances in foundation modeling have reshaped computational pathology. However, the increasing number of available models and lack of standardized benchmarks make it increasingly complex to assess their strengths, limitations, and potential…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Andrew Zhang , Guillaume Jaume , Anurag Vaidya , Tong Ding , Faisal Mahmood

Computational Pathology (CPath) is an emerging field concerned with the study of tissue pathology via computational algorithms for the processing and analysis of digitized high-resolution images of tissue slides. Recent deep learning based…

Image and Video Processing · Electrical Eng. & Systems 2021-12-20 Amina Asif , Kashif Rajpoot , David Snead , Fayyaz Minhas , Nasir Rajpoot

Concept-based models naturally lend themselves to the development of inherently interpretable skin lesion diagnosis, as medical experts make decisions based on a set of visual patterns of the lesion. Nevertheless, the development of these…

Computer Vision and Pattern Recognition · Computer Science 2024-03-07 Cristiano Patrício , Luís F. Teixeira , João C. Neves

We present a systematic evaluation of representation learning objectives for particle physics within a unified framework. Our study employs a shared transformer-based particle-cloud encoder with standardized preprocessing, matched sampling,…

Machine Learning · Computer Science 2025-11-18 Michael Chen , Raghav Kansal , Abhijith Gandrakota , Zichun Hao , Jennifer Ngadiuba , Maria Spiropulu

Skin cancer is a common and fast rising malignancy worldwide. Early detection is critical for improving outcomes. Deep learning models trained on dermoscopic and clinical images can support automated and fast triage. However, many studies…

Computer Vision and Pattern Recognition · Computer Science 2026-05-27 Durjoy Dey , Yuhong Yan , Hassan Hajjdiab

Foundation models have recently achieved impressive success in computational pathology, demonstrating strong generalization across diverse histopathology tasks. However, existing models overlook the heterogeneous and non-uniform…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Di Zhang , Zhangpeng Gong , Xiaobo Pang , Jiashuai Liu , Junbo Lu , Hao Cui , Jiusong Ge , Zhi Zeng , Kai Yi , Yinghua Li , Si Liu , Tingsong Yu , Haoran Wang , Mireia Crispin-Ortuzar , Weimiao Yu , Chen Li , Zeyu Gao

Analyzing the similarity of internal representations has been an important technique for understanding the behavior of deep neural networks. Most existing methods for analyzing the similarity between representations of high dimensions, such…

Artificial Intelligence · Computer Science 2025-05-26 Jiachen Jiang , Jinxin Zhou , Zhihui Zhu

Vision-language models pre-trained at large scale have shown unprecedented adaptability and generalization to downstream tasks. Although its discriminative potential has been widely explored, its reliability and uncertainty are still…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Julio Silva-Rodríguez , Ismail Ben Ayed , Jose Dolz

Due to the increasing workload of pathologists, the need for automation to support diagnostic tasks and quantitative biomarker evaluation is becoming more and more apparent. Foundation models have the potential to improve generalizability…

Image and Video Processing · Electrical Eng. & Systems 2025-01-13 Till Nicke , Jan Raphael Schaefer , Henning Hoefener , Friedrich Feuerhake , Dorit Merhof , Fabian Kiessling , Johannes Lotz

Conventional computer vision models rely on very deep, feedforward networks processing whole images and trained offline with extensive labeled data. In contrast, biological vision relies on comparatively shallow, recurrent networks that…

Neural and Evolutionary Computing · Computer Science 2024-11-27 Osvaldo M Velarde , Lucas C Parra

Artificial intelligence foundation models are increasingly deployed for prostate cancer Gleason grading, where GP3/GP4 distinction directly impacts treatment decisions. However, these models may achieve high validation accuracy by learning…

Computer Vision and Pattern Recognition · Computer Science 2025-12-18 Joshua L. Ebbert , Dennis Della Corte

Whole slide imaging (WSI) has transformed digital pathology by enabling computational analysis of gigapixel histopathology images. Recent foundation model advances have accelerated progress in computational pathology, facilitating joint…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Peihang Wu , Zehong Chen , Lijian Xu
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