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Pathology reports are structured, multi-granular documents encoding diagnostic conclusions, histological grades, and ancillary test results across one or more anatomical sites; yet existing pathology vision-language models (VLMs) reduce…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Ruicheng Yuan , Zhenxuan Zhang , Anbang Wang , Liwei Hu , Xiangqian Hua , Yaya Peng , Jiawei Luo , Guang Yang

Computational pathology needs whole-slide image (WSI) foundation models that transfer across diverse clinical tasks, yet current approaches remain largely slide-centric, often depend on private data and expensive paired-report supervision,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-02 Yousef Kotp , Vincent Quoc-Huy Trinh , Christopher Pal , Mahdi S. Hosseini

Computational pathology (CPath) has shown great potential in mining actionable insights from Whole Slide Images (WSIs). Deep Learning (DL) has been at the center of modern CPath, and while it delivers unprecedented performance, it is also…

Quantitative Methods · Quantitative Biology 2025-07-31 Gianluca Carloni , Biagio Brattoli , Seongho Keum , Jongchan Park , Taebum Lee , Chang Ho Ahn , Sergio Pereira

Pathology foundation models (PFMs) have emerged as a core approach for learning transferable representations from whole slide images (WSIs), and they are typically benchmarked through downstream clinical endpoints. While such task level…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Bokai Zhao , Yiyang Zhang , Yuanchi Zhu , Hanqing Chao , Long Bai , Tai Ma , Minfeng Xu , Ming Song , Tianzi Jiang

Computational pathology (CPath) digitizes pathology slides into whole slide images (WSIs), enabling analysis for critical healthcare tasks such as cancer diagnosis and prognosis. However, WSIs possess extremely long sequence lengths (up to…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Wenhao Tang , Heng Fang , Ge Wu , Xiang Li , Ming-Ming Cheng

Despite the promise of computational pathology foundation models, adapting them to specific clinical tasks remains challenging due to the complexity of whole-slide image (WSI) processing, the opacity of learned features, and the wide range…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Abdul Rahman Diab , Emily E. Karn , Renchin Wu , Emily S. Ruiz , William Lotter

Recent advances in self-supervision and contrastive learning have brought the performance of foundation models to unprecedented levels in a variety of tasks. Fueled by this progress, these models are becoming the prevailing approach for a…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Leo Fillioux , Julio Silva-Rodríguez , Ismail Ben Ayed , Paul-Henry Cournède , Maria Vakalopoulou , Stergios Christodoulidis , Jose Dolz

Foundation models (FMs) have demonstrated strong performance across diverse pathology tasks. While there are similarities in the pre-training objectives of FMs, there is still limited understanding of their complementarity, redundancy in…

Computer Vision and Pattern Recognition · Computer Science 2025-12-15 Brennan Flannery , Thomas DeSilvio , Jane Nguyen , Satish E. Viswanath

Recent advancements in foundation models have transformed computer vision, driving significant performance improvements across diverse domains, including digital histopathology. However, the advantages of domain-specific histopathology…

Computer Vision and Pattern Recognition · Computer Science 2025-02-05 Valentina Vadori , Antonella Peruffo , Jean-Marie Graïc , Livio Finos , Enrico Grisan

Foundation models pre-trained on web-scale vision-language data, such as CLIP, are widely used as cornerstones of powerful machine learning systems. While pre-training offers clear advantages for downstream learning, it also endows…

Computer Vision and Pattern Recognition · Computer Science 2024-03-20 Anjun Hu , Jindong Gu , Francesco Pinto , Konstantinos Kamnitsas , Philip Torr

There exist numerous diagnostic tasks in pathology. Conventional computational pathology formulates and tackles them as independent and individual image classification problems, thereby resulting in computational inefficiency and high…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Anh Tien Nguyen , Keunho Byeon , Kyungeun Kim , Boram Song , Seoung Wan Chae , Jin Tae Kwak

The diagnosis of pathological images is often limited by expert availability and regional disparities, highlighting the importance of automated diagnosis using Vision-Language Models (VLMs). Traditional multimodal models typically emphasize…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Jianyu Wu , Hao Yang , Xinhua Zeng , Guibing He , Zhiyu Chen , Zihui Li , Xiaochuan Zhang , Yangyang Ma , Run Fang , Yang Liu

Contrastive Language-Image Pretraining (CLIP) stands out as a prominent method for image representation learning. Various neural architectures, spanning Transformer-based models like Vision Transformers (ViTs) to Convolutional Networks…

Computer Vision and Pattern Recognition · Computer Science 2023-12-25 Cristian Rodriguez-Opazo , Edison Marrese-Taylor , Ehsan Abbasnejad , Hamed Damirchi , Ignacio M. Jara , Felipe Bravo-Marquez , Anton van den Hengel

Computational pathology relies on effective representation learning to support cancer research and precision medicine. Although self-supervised learning has driven major progress at the patch and whole-slide image levels, representation…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Loïc Chadoutaud , Alice Blondel , Hana Feki , Jacqueline Fontugne , Emmanuel Barillot , Thomas Walter

With the rapid advancement of pathology foundation models (FMs), the representation learning of whole slide images (WSIs) attracts increasing attention. Existing studies develop high-quality patch feature extractors and employ carefully…

Computer Vision and Pattern Recognition · Computer Science 2025-03-27 Yuxuan Chen , Jiawen Li , Jiali Hu , Xitong Ling , Tian Guan , Anjia Han , Yonghong He

In recent years, a standard computational pathology workflow has emerged where whole slide images are cropped into tiles, these tiles are processed using a foundation model, and task-specific models are built using the resulting…

Computer Vision and Pattern Recognition · Computer Science 2026-02-26 Eric Zimmermann , Julian Viret , Michal Zelechowski , James Brian Hall , Neil Tenenholtz , Adam Casson , George Shaikovski , Eugene Vorontsov , Siqi Liu , Kristen A Severson

Recent advances in computational pathology have led to the emergence of numerous foundation models. These models typically rely on general-purpose encoders with multi-instance learning for whole slide image (WSI) classification or apply…

Computer Vision and Pattern Recognition · Computer Science 2025-10-29 Yuxuan Sun , Yixuan Si , Chenglu Zhu , Kai Zhang , Zhongyi Shui , Bowen Ding , Tao Lin , Lin Yang

Computational Pathology CPath is an interdisciplinary science that augments developments of computational approaches to analyze and model medical histopathology images. The main objective for CPath is to develop infrastructure and workflows…

In this paper, we present a comparative analysis of various self-supervised Vision Transformers (ViTs), focusing on their local representative power. Inspired by large language models, we examine the abilities of ViTs to perform various…

Computer Vision and Pattern Recognition · Computer Science 2024-03-22 Ani Vanyan , Alvard Barseghyan , Hakob Tamazyan , Vahan Huroyan , Hrant Khachatrian , Martin Danelljan

Foundation models are increasingly applied to computational pathology, yet their behavior under cross-cancer and cross-species transfer remains unspecified. This study investigated how fine-tuning CPath-CLIP affects cancer detection under…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Ekansh Arora