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Pathology foundation models (PFMs) have emerged as powerful pretrained encoders for computational pathology, but their robustness under clinically relevant distribution shifts remains insufficiently understood. We benchmark the robustness…

Image and Video Processing · Electrical Eng. & Systems 2026-04-29 Fredrik K. Gustafsson , Mattias Rantalainen

Foundation models learn highly transferable representations through large-scale pretraining on diverse data. An increasing body of research indicates that these representations exhibit a remarkable degree of similarity across architectures…

Artificial Intelligence · Computer Science 2025-10-08 Jianglin Lu , Hailing Wang , Yi Xu , Yizhou Wang , Kuo Yang , Yun Fu

NLP-based computer vision models, particularly vision transformers, have been shown to outperform CNN models in many imaging tasks. However, most digital pathology artificial-intelligence models are based on CNN architectures, probably…

Computation and Language · Computer Science 2023-02-22 Min Cen , Xingyu Li , Bangwei Guo , Jitendra Jonnagaddala , Hong Zhang , Xu Steven Xu

Unsupervised image complexity representation often suffers from bias in positive sample selection and sensitivity to image content. We propose CLICv2, a contrastive learning framework that enforces content invariance for complexity…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Shipeng Liu , Liang Zhao , Dengfeng Chen

CLIP is one of the most popular foundational models and is heavily used for many vision-language tasks. However, little is known about the inner workings of CLIP. To bridge this gap we propose a study to quantify the interpretability in…

Computer Vision and Pattern Recognition · Computer Science 2024-09-11 Avinash Madasu , Yossi Gandelsman , Vasudev Lal , Phillip Howard

Background and objective: Cell-level pathological image analysis requires working with extremely small image patches (40x40 pixels), far below standard ImageNet resolutions. It remains unclear whether modern deep learning architectures and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Hiroki Kagiyama , Toru Nagasaka , Yukari Adachi , Takaaki Tachibana , Ryota Ito , Mitsugu Fujita , Kimihiro Yamashita , Yoshihiro Kakeji

Deep Learning-based computational pathology algorithms have demonstrated profound ability to excel in a wide array of tasks that range from characterization of well known morphological phenotypes to predicting non-human-identifiable…

Image and Video Processing · Electrical Eng. & Systems 2020-09-24 Ming Y. Lu , Dehan Kong , Jana Lipkova , Richard J. Chen , Rajendra Singh , Drew F. K. Williamson , Tiffany Y. Chen , Faisal Mahmood

Foundation models in digital pathology use massive datasets to learn useful compact feature representations of complex histology images. However, there is limited transparency into what drives the correlation between dataset size and…

Recent advances in whole slide imaging (WSI) technology have led to the development of a myriad of computer vision and artificial intelligence (AI) based diagnostic, prognostic, and predictive algorithms. Computational Pathology (CPath)…

Joint RGB-infrared perception is essential for achieving robustness under diverse weather and illumination conditions. Although foundation models excel within single modalities, they suffer from substantial cross-modal degradation, an issue…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Fangyuan Mao , Shuo Wang , Jilin Mei , Shun Lu , Chen Min , Fuyang Liu , Xiaokun Feng , Meiqi Wu , Yu Hu

Computational pathology has made significant progress in recent years, fueling advances in both fundamental disease understanding and clinically ready tools. This evolution is driven by the availability of large amounts of digitized slides…

Deep learning models have shown immense promise in computational pathology (CPath) tasks, but their performance often suffers when applied to unseen data due to domain shifts. Addressing this requires domain generalization (DG) algorithms.…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Neda Zamanitajeddin , Mostafa Jahanifar , Kesi Xu , Fouzia Siraj , Nasir Rajpoot

The emergence of foundation models in computational pathology has transformed histopathological image analysis, with whole slide imaging (WSI) diagnosis being a core application. Traditionally, weakly supervised fine-tuning via multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Jiawen Li , Jiali Hu , Qiehe Sun , Renao Yan , Minxi Ouyang , Tian Guan , Anjia Han , Chao He , Yonghong He

Latent image representations arising from vision-language models have proved immensely useful for a variety of downstream tasks. However, their utility is limited by their entanglement with respect to different visual attributes. For…

Computer Vision and Pattern Recognition · Computer Science 2023-11-14 James Oldfield , Christos Tzelepis , Yannis Panagakis , Mihalis A. Nicolaou , Ioannis Patras

The examination of histopathology images is considered to be the gold standard for the diagnosis and stratification of cancer patients. A key challenge in the analysis of such images is their size, which can run into the gigapixels and can…

Image and Video Processing · Electrical Eng. & Systems 2021-09-09 Joseph Boyd , Mykola Liashuha , Eric Deutsch , Nikos Paragios , Stergios Christodoulidis , Maria Vakalopoulou

Large amounts of digitized histopathological data display a promising future for developing pathological foundation models via self-supervised learning methods. Foundation models pretrained with these methods serve as a good basis for…

Computer Vision and Pattern Recognition · Computer Science 2024-08-07 Shengyi Hua , Fang Yan , Tianle Shen , Lei Ma , Xiaofan Zhang

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Fengchun Liu , Songhan Jiang , Linghan Cai , Ziyue Wang , Yongbing Zhang

Object-centric (OC) representations, which model visual scenes as compositions of discrete objects, have the potential to be used in various downstream tasks to achieve systematic compositional generalization and facilitate reasoning.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Amir Mohammad Karimi Mamaghan , Samuele Papa , Karl Henrik Johansson , Stefan Bauer , Andrea Dittadi

Rapid development of large-scale pre-training has resulted in foundation models that can act as effective feature extractors on a variety of downstream tasks and domains. Motivated by this, we study the efficacy of pre-trained vision models…

Machine Learning · Computer Science 2022-07-05 Oleksiy Ostapenko , Timothee Lesort , Pau Rodríguez , Md Rifat Arefin , Arthur Douillard , Irina Rish , Laurent Charlin

Cancer progression arises from interactions across multiple biological layers, especially beyond morphological and across molecular layers that remain invisible to image-only models. To capture this broader biological landscape, we present…

Machine Learning · Computer Science 2025-12-17 Juseung Yun , Sunwoo Yu , Sumin Ha , Jonghyun Kim , Janghyeon Lee , Jongseong Jang , Soonyoung Lee