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Cell type identification from single-cell transcriptomic data is a common goal of single-cell RNA sequencing (scRNAseq) data analysis. Neural networks have been employed to identify cell types from scRNAseq data with high performance.…

Genomics · Quantitative Biology 2020-05-11 Xishuang Dong , Shanta Chowdhury , Uboho Victor , Xiangfang Li , Lijun Qian

Transformers evaluated in a single, fixed-depth pass are provably limited in expressive power to the constant-depth circuit class TC0. Running a Transformer autoregressively removes that ceiling -- first in next-token prediction and, more…

Machine Learning · Computer Science 2025-07-21 Mrinal Mathur , Mike Doan , Barak Pearlmutter , Sergey Plis

Research on long non-coding RNAs (lncRNAs) has garnered significant attention due to their critical roles in gene regulation and disease mechanisms. However, the complexity and diversity of lncRNA sequences, along with the limited knowledge…

Genomics · Quantitative Biology 2024-11-07 Wei Wang , Zhichao Hou , Xiaorui Liu , Xinxia Peng

Single-cell RNA sequencing (scRNA-seq) provides high-dimensional profiles of cellular states, enabling data-driven modeling of cellular dynamics over time. In practice, time-resolved scRNA-seq is collected at only a few discrete time points…

Machine Learning · Computer Science 2026-05-22 Siyu Pu , Qingqing Long , Xiaohan Huang , Haotian Chen , Jiajia Wang , Meng Xiao , Xiao Luo , Hengshu Zhu , Yuanchun Zhou , Xuezhi Wang

The development of single-cell and spatial transcriptomics has revolutionized our capacity to investigate cellular properties, functions, and interactions in both cellular and spatial contexts. However, the analysis of single-cell and…

Genomics · Quantitative Biology 2024-12-09 Shuang Ge , Shuqing Sun , Huan Xu , Qiang Cheng , Zhixiang Ren

Large Language Models (LLMs) are traditionally viewed as black-box algorithms, therefore reducing trustworthiness and obscuring potential approaches to increasing performance on downstream tasks. In this work, we apply an effective LLM…

Computation and Language · Computer Science 2025-07-10 Shun Wang , Tyler Loakman , Youbo Lei , Yi Liu , Bohao Yang , Yuting Zhao , Dong Yang , Chenghua Lin

Vision transformer based models bring significant improvements for image segmentation tasks. Although these architectures offer powerful capabilities irrespective of specific segmentation tasks, their use of computational resources can be…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Manyi Yao , Abhishek Aich , Yumin Suh , Amit Roy-Chowdhury , Christian Shelton , Manmohan Chandraker

Transformers have excelled in natural language modeling and one reason behind this success is their exceptional ability to combine contextual informal and global knowledge. However, the theoretical basis remains unclear. In this paper,…

Machine Learning · Computer Science 2024-11-01 Yunwei Ren , Zixuan Wang , Jason D. Lee

Cell identity encompasses various semantic aspects of a cell, including cell type, pathway information, disease information, and more, which are essential for biologists to gain insights into its biological characteristics. Understanding…

Genomics · Quantitative Biology 2024-06-12 Suyuan Zhao , Jiahuan Zhang , Yushuai Wu , Yizhen Luo , Zaiqing Nie

Interpretability is a critical factor in applying complex deep learning models to advance the understanding of brain disorders in neuroimaging studies. To interpret the decision process of a trained classifier, existing techniques typically…

Image and Video Processing · Electrical Eng. & Systems 2021-06-29 Zixuan Liu , Ehsan Adeli , Kilian M. Pohl , Qingyu Zhao

With the continue development of Convolutional Neural Networks (CNNs), there is a growing concern regarding representations that they encode internally. Analyzing these internal representations is referred to as model interpretation. While…

Computer Vision and Pattern Recognition · Computer Science 2023-05-18 Hamed Behzadi-Khormouji , José Oramas

Automating analog circuit design remains a longstanding challenge in Electronic Design Automation (EDA). While Transformer-based Large Language Models (LLMs) have revolutionized software code generation, their application to analog hardware…

Artificial Intelligence · Computer Science 2026-05-08 Md Touhidul Islam , Sujan Kumar Saha , Farimah Farahmandi , Mark Tehranipoor

Photon counting spectral CT (PCCT) can produce reconstructed attenuation maps in different energy channels, reflecting energy properties of the scanned object. Due to the limited photon numbers and the non-ideal detector response of each…

Image and Video Processing · Electrical Eng. & Systems 2022-01-27 Chaoyang Zhang , Shaojie Chang , Ti Bai , Xi Chen

We present a systematic review of 337 articles evaluating the syntactic abilities of Transformer-based language models (TLMs), reporting on over 3,000 datapoints spanning a wide range of syntactic phenomena, languages, models, and methods.…

Computation and Language · Computer Science 2026-05-28 Nora Graichen , Iria de-Dios-Flores , Gemma Boleda

Transformer large language models (LLMs) have sparked admiration for their exceptional performance on tasks that demand intricate multi-step reasoning. Yet, these models simultaneously show failures on surprisingly trivial problems. This…

Foundation models are used to extract transferable representations from large amounts of unlabeled data, typically via self-supervised learning (SSL). However, many of these models rely on architectures that offer limited interpretability,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Samuel Ofosu Mensah , Camila Roa , Kerol Djoumessi , Philipp Berens

Mechanistic interpretability often identifies circuits inside Transformer models, but explanations of those circuits are usually validated through examples, ablations, and manual reasoning. This leaves a gap between finding a plausible…

Machine Learning · Computer Science 2026-05-26 Neel Somani

This work builds together two popular blocks of neural architecture, namely convolutional layers and Transformers, for large language models (LLMs). Non-causal conformers are used ubiquitously in automatic speech recognition. This work aims…

Computation and Language · Computer Science 2023-07-04 Prateek Verma

Multi-criteria Chinese word segmentation (MCCWS) aims to exploit the relations among the multiple heterogeneous segmentation criteria and further improve the performance of each single criterion. Previous work usually regards MCCWS as…

Computation and Language · Computer Science 2020-10-06 Xipeng Qiu , Hengzhi Pei , Hang Yan , Xuanjing Huang

Transformers have achieved great success in effectively processing sequential data such as text. Their architecture consisting of several attention and feedforward blocks can model relations between elements of a sequence in parallel…

Machine Learning · Computer Science 2025-02-20 Jaemu Heo , Eldor Fozilov , Hyunmin Song , Taehwan Kim
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