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Following their success across many domains, transformers have also proven effective for symbolic regression (SR); however, the internal mechanisms underlying their generation of mathematical operators remain largely unexplored. Although…

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Advances in large-scale recording technologies now enable simultaneous measurements from multiple brain areas, offering new opportunities to study signal transmission across interacting components of neural circuits. However, neural…

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In this paper, we propose an easily trained yet powerful representation learning approach with performance highly competitive to deep neural networks in a digital pathology image segmentation task. The method, called sparse coding driven…

Computer Vision and Pattern Recognition · Computer Science 2020-08-14 Jie Song , Liang Xiao , Mohsen Molaei , Zhichao Lian

Intelligent spectrum management is crucial for improving spectrum efficiency and achieving secure utilization of spectrum resources. However, existing intelligent spectrum management methods, typically based on small-scale models, suffer…

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Large language models excel at interpreting complex natural language instructions, enabling them to perform a wide range of tasks. In the life sciences, single-cell RNA sequencing (scRNA-seq) data serves as the "language of cellular…

Computation and Language · Computer Science 2025-01-16 Yin Fang , Xinle Deng , Kangwei Liu , Ningyu Zhang , Jingyang Qian , Penghui Yang , Xiaohui Fan , Huajun Chen

Although convolutional neural networks (CNNs) have achieved remarkable progress in weakly supervised semantic segmentation (WSSS), the effective receptive field of CNN is insufficient to capture global context information, leading to…

Computer Vision and Pattern Recognition · Computer Science 2022-03-17 Chunmeng Liu , Enze Xie , Wenjia Wang , Wenhai Wang , Guangyao Li , Ping Luo

We present a framework for modeling superconducting circuits that integrates classical microwave analysis with circuit quantization. Our framework enables the calculation of the lossy eigenmodes of superconducting circuits, and we…

Quantum Physics · Physics 2019-03-22 Michael G. Scheer , Maxwell B. Block

The general-purpose nature of Large Language Models (LLMs) presents a significant challenge for domain-specific applications, often leading to out-of-domain (OOD) interactions that undermine the provider's intent. Existing methods for…

Artificial Intelligence · Computer Science 2026-05-13 Elias Shaheen , Avi Mendelson

For large language models (LLMs), sparse autoencoders (SAEs) have been shown to decompose intermediate representations that often are not interpretable directly into sparse sums of interpretable features, facilitating better control and…

Computational modeling of single-cell gene expression is crucial for understanding cellular processes, but generating realistic expression profiles remains a major challenge. This difficulty arises from the count nature of gene expression…

Modern Foundation Models (FMs) are typically trained on corpora spanning a wide range of different data modalities, topics and downstream tasks. Utilizing these models can be very computationally expensive and is out of reach for most…

Machine Learning · Computer Science 2025-06-09 Andrey Zhmoginov , Jihwan Lee , Mark Sandler

Understanding the biological mechanisms of disease is crucial for medicine, and in particular, for drug discovery. AI-powered analysis of genome-scale biological data holds great potential in this regard. The increasing availability of…

Identity, response to external stimuli, and spatial architecture of a living system are central topics of molecular biology. Presently, they are largely seen as a result of the interplay between a gene repertoire and the regulatory…

Molecular Networks · Quantitative Biology 2007-05-23 M. Cosentino Lagomarsino , P. Jona , B. Bassetti

Interpreting the internal activations of neural networks can produce more faithful explanations of their behavior, but is difficult due to the complex structure of activation space. Existing approaches to scalable interpretability use…

Artificial Intelligence · Computer Science 2025-12-18 Vincent Huang , Dami Choi , Daniel D. Johnson , Sarah Schwettmann , Jacob Steinhardt

Large-scale pre-trained vision foundation models, such as CLIP, have become de facto backbones for various vision tasks. However, due to their black-box nature, understanding the underlying rules behind these models' predictions and…

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Understanding how 5' untranslated regions (5'UTRs) regulate mRNA translation is critical for controlling protein expression and designing effective therapeutic mRNAs. While recent deep learning models have shown promise in predicting…

Quantitative Methods · Quantitative Biology 2026-02-27 Yuxi Lin , Yaxue Fang , Zehong Zhang , Zhouwu Liu , Siyun Zhong , Zhongfang Wang , Fulong Yu

In this work, we introduce CellxPert, a scalable multimodal foundation model that unifies single-cell and spatial multi-omics within a common representation space. CellxPert jointly encodes transcriptomic (scRNA-seq),…

Genomics · Quantitative Biology 2026-05-05 Andac Demir , Erik W. Anderson , Jeremy L. Jenkins , Srayanta Mukherjee

In recent times, Large Language Models (LLMs) have captured a global spotlight and revolutionized the field of Natural Language Processing. One of the factors attributed to the effectiveness of LLMs is the model architecture used for…

Machine Learning · Computer Science 2023-08-31 Oluwaseyi Ogunfowora , Homayoun Najjaran

The success of a specific neural network architecture is closely tied to the dataset and task it tackles; there is no one-size-fits-all solution. Thus, considerable efforts have been made to quickly and accurately estimate the performances…

Machine Learning · Computer Science 2024-03-22 Dongyeong Hwang , Hyunju Kim , Sunwoo Kim , Kijung Shin

Transformer-based neural decoders have emerged as a promising approach to error correction coding, combining data-driven adaptability with efficient modeling of long-range dependencies. This paper presents a novel decoder architecture that…

Information Theory · Computer Science 2025-09-22 Chin Wa Lau , Xiang Shi , Ziyan Zheng , Haiwen Cao , Nian Guo
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