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The industrial production of microalgae is an important and sustainable process, but its actual competitiveness is closely related to its optimization. The biological nature of the process hinders this task, mainly due to the high…

Systems and Control · Electrical Eng. & Systems 2025-12-18 Pablo Otálora , Sigurd Skogestad , José Luis Guzmán , Manuel Berenguel

We investigate optimization of an algal-bacterial consortium, where an exogenous control input modulates bacterial resource allocation between growth and synthesis of a resource that is limiting for algal growth. Maximization of algal…

Optimization and Control · Mathematics 2024-10-14 Rand Asswad , Walid Djema , Olivier Bernard , Jean-Luc Gouzé , Eugenio Cinquemani

The potential of industrial applications for microalgae has motivated their recent fast development. Their growth dynamics depends on different factors that must be optimized. Since they get their energy from photosynthesis, light is a key…

Numerical Analysis · Mathematics 2021-08-24 Olivier Bernard , Liu-Di Lu

We address the question of optimization of the microalgal biomass long term productivity in the framework of production in photobioreactors under the influence of day/night cycles. For that, we propose a simple bioreactor model accounting…

Optimization and Control · Mathematics 2012-04-16 Frédéric Grognard , Andrei R. Akhmetzhanov , Olivier Bernard

We address the question of optimization of the biomass long term productivity in the framework of microalgal biomass production in photobioreactors under the influence of day/night cycles. For that, we propose a simple bioreactor model…

Optimization and Control · Mathematics 2010-09-14 Frédéric Grognard , Andrei R. Akhmetzhanov , Masci Pierre , Olivier Bernard

Cultivating oleaginous microalgae in specific culturing devices such as raceways is seen as a future way to produce biofuel. The complexity of this process coupling non linear biological activity to hydrodynamics makes the optimization…

Numerical Analysis · Mathematics 2012-09-05 Olivier Bernard , Anne-Celine Boulanger , Marie-Odile Bristeau , Jacques Sainte-Marie

In this work we present a novel methodology to deal with the optimal performance of raceways (open-channel ponds where the circulating wastewater, during its purification process, is used to grow algae that will be used as a source for the…

Optimization and Control · Mathematics 2024-12-02 L. J. Alvarez-Vazquez , A. Martinez , M. E. Vazquez-Mendez

In this article, we focus on a periodic resource allocation problem applied to a dynamical system which comes from a biological system. More precisely, we consider a system with $N$ resources and $N$ activities, each activity use the…

Numerical Analysis · Mathematics 2022-06-01 Olivier Bernard , Liu-Di Lu , Julien Salomon

We present a coupled model describing growth of microalgae in a raceway cultivation process, accounting for hydrodynamics. Our approach combines a biological model (based on the Han model) and shallow water dynamics equations that model the…

Optimization and Control · Mathematics 2020-11-10 Olivier Bernard , Liudi Lu , Jacques Marie , Julien Salomon

We revisit the optimal control problem of maximizing biogas production in continuous bio-processes in two directions: 1. over an infinite horizon, 2. with sub-optimal controllers independent of the time horizon. For the first point, we…

Optimization and Control · Mathematics 2019-06-10 Antoine Haddon , Hector Ramirez , Alain Rapaport

Controlling microalgae cultivation, i.e., a crucial industrial topic today, is a challenging task since the corresponding modeling is complex, highly uncertain and time-varying. A model-free control setting is therefore introduced in order…

Systems and Control · Computer Science 2021-01-25 Sihem Tebbani , Mariana Titica , Cédric Join , Michel Fliess , Didier Dumur

This paper presents a benchmarking framework to evaluate process control strategies in outdoor microalgae raceway reactors, integrating four key control regulation tasks: pH, dissolved oxygen (DO), culture volume through coordinated…

Systems and Control · Electrical Eng. & Systems 2025-12-19 Enrique Rodríguez-Miranda , Pablo Otálora , José González-Hernández , José Luis Guzmán , Manuel Berenguel

Biotechnology offers many opportunities for the sustainable manufacturing of valuable products. The toolbox to optimize bioprocesses includes \textit{extracellular} process elements such as the bioreactor design and mode of operation,…

Systems and Control · Electrical Eng. & Systems 2023-02-07 Sebastián Espinel-Ríos , Bruno Morabito , Johannes Pohlodek , Katja Bettenbrock , Steffen Klamt , Rolf Findeisen

This paper focuses on mixing strategies to enhance the growth of microalgae in a raceway pond. The flow is assumed to be laminar and the Han model describing the dynamics of the photosystems is used as a basis to determine growth rate as a…

Optimization and Control · Mathematics 2020-10-22 Olivier Bernard , Liudi Lu , Julien Salomon

One of the challenges in Synthetic Biology is to design circuits with increasing levels of complexity. While circuits in Biology are complex and subject to natural tradeoffs, most synthetic circuits are simple in terms of the number of…

Optimization and Control · Mathematics 2014-03-03 Irene Otero-Muras , Julio R. Banga

The production process involved in the creation of biofuels consists of a number of operations and steps that require a meticulous understanding of the parameters and metrics. The production techniques again differ depending on the…

Other Quantitative Biology · Quantitative Biology 2023-08-03 Amardeep Singh

Production of chemicals from engineered organisms in a batch culture involves an inherent trade-off between productivity, yield, and titer. Existing strategies for strain design typically focus on designing mutations that achieve the…

Quantitative Methods · Quantitative Biology 2016-10-05 Peter C. St. John , Michael F. Crowley , Yannick J. Bomble

We consider optimizing for different production requirements from the viewpoint of a bio-inspired framework for system flexibility that allows us to study the ability of an algorithm to transfer solutions from previous optimization tasks,…

Neural and Evolutionary Computing · Computer Science 2025-10-03 Leo Francoso Dal Piccol Sotto , Sebastian Mayer , Hemanth Janarthanam , Alexander Butz , Jochen Garcke

This paper focuses on mixing strategies and designing shape of the bottom topographies to enhance the growth of the microalgae in raceway ponds. A physical-biological coupled model is used to describe the growth of the algae. A simple model…

Numerical Analysis · Mathematics 2020-11-24 Olivier Bernard , Liu-Di Lu , Julien Salomon

We maximize the production of biogas in a gradostat at steady state. The physical decision variables are the water, substrate, and biomass entering each tank and the flows through the interconnecting pipes. Our main technical focus is the…

Optimization and Control · Mathematics 2021-02-04 Josh Taylor , Alain Rapaport
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