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Sensitive mid-infrared (MIR) spectroscopy plays an indispensable role in various photon-starved conditions. However, the detection sensitivity of conventional MIR spectrometers is severely limited by excessive noises of the involved…

Sensitive mid-infrared (MIR) spectroscopy is highly demanded in various fields ranging from industrial inspection, biomedical diagnosis to astronomical observation. However, the detection sensitivity of conventional MIR spectrometers has…

Mid-infrared (MIR) imaging offers powerful capabilities for label-free chemical analysis, yet its practical deployment remains hindered by the high cost and cryogenic complexity of conventional cameras. Two-photon absorption (TPA) provides…

Optics · Physics 2026-05-25 Huijie Ma , Kun Huang , Jianan Fang , Ziyu He , Yan Liang , Heping Zeng

Advancement in mid-infrared (MIR) technology has led to promising biomedical applications of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR microscopy has been rarely used for live biological samples in an…

Room temperature detection of molecular vibrations in the mid-infrared (MIR, $\lambda$ =3-30$\mu$m) has numerous applications including real-time gas sensing, chemical reactivity, medical imaging, astronomical surveys, and quantum…

Applied Physics · Physics 2022-05-17 Rohit Chikkaraddy , Rakesh Arul , Lukas A. Jakob , Jeremy J. Baumberg

Mid-infrared (MIR) spectroscopy is widely recognized as a powerful, non-distractive method for chemical analysis. However, its utility is constrained by a micrometer-scale spatial resolution imposed by the long-wavelength MIR diffraction…

Sensing with undetected photons has become a vibrant, application-driven research domain with a special focus on the mid-infrared (mid-IR) wavelength region. Since the mid-IR contains spectral bands with highly specific and strong molecular…

Single-photon laser ranging has widespread applications in remote sensing and target recognition. However, highly-sensitive light detection and ranging (LiDAR) has long been restricted in visible or near-infrared bands. An appealing quest…

Fourier-transform infrared spectroscopy (FTIR) is an indispensable analytical method that allows label-free identification of substances via fundamental molecular vibrations. However, the sensitivity of FTIR is often limited by the low…

Near-infrared (NIR) hyperspectral imaging is widely used to reveal morphological and chemical information. However, conventional spectral imagers usually rely on costly focal plane arrays and suffer from data redundancy and inefficiencies…

Optics · Physics 2026-05-26 Ben Sun , Kun Huang , Zhibin Zhao , Beibei Dong , Jianan Fang , Heping Zeng

Spectral imaging and detection of mid-infrared (mid-IR) wavelengths are emerging as an enabling technology of great technical and scientific interest; primarily because important chemical compounds display unique and strong mid-IR spectral…

Spectral imaging in the mid-infrared (MIR) range provides simultaneous morphological and chemical information of a wide variety of samples. However, current MIR technologies struggle to produce high-definition images over a broad spectral…

Ovarian cancer detection has traditionally relied on a multi-step process that includes biopsy, tissue staining, and morphological analysis by experienced pathologists. While widely practiced, this conventional approach suffers from several…

Mid-infrared (MIR) spectral imaging enables precise target identification and analysis by capturing rich chemical fingerprints, which calls for high-sensitivity broadband MIR imagers at room temperature. Here, we devise and implement a…

Optics · Physics 2026-05-26 Yue Song , Jianan Fang , Wen Zhang , Yijing Li , Ben Sun , Zhiwei Jia , Kun Huang , Heping Zeng

Multispectral mid-infrared (2-5 ${{\mu}m}$) imaging is a critical capability across science and technology, offering a window into the vibrational and thermal landscape of matter that is inaccessible to visible sensors. It bridges the…

Optics · Physics 2026-01-29 Daniel Beitner , Ziv Abelson , Eyal Hollander , Omri Meron , Haim Suchowski

Label-free and nondestructive mid-infrared vibrational hyperspectral imaging is emerging as an important ex-vivo tissue analysis tool, providing spatially resolved biochemical information critical to understanding physiological and…

High-speed mid-infrared (MIR) videography constitutes an enabling tool to monitor and analyze various dynamics in scientific research and industrial applications, such as combustion diagnostics, explosion reactions, photosynthetic tracking,…

Optics · Physics 2026-05-28 Ruiyang Qin , Kun Huang , Min Peng , Jianan Fang , Ben Sun , Zhengru Guo , Heping Zeng

Hyperspectral microscopy is an imaging technique that provides spectroscopic information with high spatial resolution. When applied in the relevant wavelength region, such as in the infrared (IR), it can reveal a rich spectral fingerprint…

Frequency upconversion technique offers an appealing approach for sensitive mid-infrared (MIR) imaging at room temperature. However, the spatial resolution of the upconversion imager has been notoriously restricted by the limited transverse…

Ultrafast mid-infrared (MIR) imaging is a key enabling capability for monitoring transient thermal and plasma phenomena in scientific diagnostics and industrial safety. However, conventional cryogenic MIR cameras face a fundamental…

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