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We developed and experimentally verified an analytical model to describe diffusion of oligonucleotides from stable hydrogel beads. The synthesized alginate beads are Fe3+-cross-linked as well as polyelectrolyte-doped for uniformity and…

Soft Condensed Matter · Physics 2016-06-07 Vladimir Privman , Sergii Domanskyi , Roberto A. S. Luz , Nataliia Guz , M. Lawrence Glasser , Evgeny Katz

Chemical reactions are a prominent feature of molecular communication (MC) systems, with no direct parallels in wireless communications. While chemical reactions may be used inside the transmitter nodes, receiver nodes or the communication…

Information Theory · Computer Science 2018-04-25 Maryam Farahnak-Ghazani , Gholamali Aminian , Mahtab Mirmohseni , Amin Gohari , Masoumeh Nasiri-Kenari

Communication and coordination play a major role in the ability of bacterial cells to adapt to ever changing environments and conditions. Recent work has shown that such coordination underlies several aspects of bacterial responses…

Quantitative Methods · Quantitative Biology 2016-04-12 Shashank Singh , Sabrina Rashid , Zhicheng Long , Saket Navlakha , Hanna Salman , Zoltan N. Oltvai , Ziv Bar-Joseph

The study of the ability of drug molecules to enter cells through the membrane is of vital importance in the field of drug delivery. In cases where the transport of the drug molecules through the membrane is not easily accomplishable, other…

Soft Condensed Matter · Physics 2015-03-17 Sridhar Akshay , Bharath Srikanth , Amit Kumar , Ashok Kumar Dasmahapatra

Molecular Communications (MC) is an emerging research paradigm that utilizes molecules to transmit information, with promising applications in biomedicine such as targeted drug delivery or tumor detection. It is also envisioned as a key…

Signal Processing · Electrical Eng. & Systems 2025-11-05 Martín Schottlender , Maximilian Schäfer , Ricardo A. Veiga

The diffusion of molecules (penetrants) of variable size, shape, and chemistry through dense crosslinked polymer networks is a fundamental scientific problem that is broadly relevant in materials, polymer, physical and biological chemistry.…

Discrete diffusion models have recently emerged as a powerful class of generative models for chemistry and biology data. In these fields, the goal is to generate various samples with high rewards (e.g., drug-likeness in molecules), making…

Machine Learning · Computer Science 2026-02-11 Prin Phunyaphibarn , Minhyuk Sung

In this paper, a novel non-uniform Binary Concentration Shift Keying (BCSK) modulation in the course of molecular communication is introduced. We consider the nutrient limiting as the main reason for avoiding the nanotransmitters to release…

Signal Processing · Electrical Eng. & Systems 2019-05-16 Hamid Khoshfekr Rudsari , Mahdi Orooji , Mohammad Reza Javan , Nader Mokari , Eduard A. Jorswieck

Predicting the release performance of a drug delivery device is an important challenge in pharmaceutics and biomedical science. In this paper, we consider a multi-layer diffusion model of drug release from a composite spherical microcapsule…

Medical Physics · Physics 2019-01-25 Elliot J. Carr , Giuseppe Pontrelli

The transport of deformable particles through porous media underlies a wealth of applications ranging from filtration to oil recovery to the transport and spreading of biological agents. Using direct numerical simulations, we analyze the…

Soft Condensed Matter · Physics 2020-06-09 Brato Chakrabarti , Charles Gaillard , David Saintillan

A fuel cell system must output a steady voltage as a power source in practical use. A neural network (NN) based model predictive control (MPC) approach is developed in this work to regulate the fuel cell output voltage with safety…

Systems and Control · Electrical Eng. & Systems 2024-06-26 Xiufei Li , Miao Yang , Yuanxin Qi , Miao Zhang

Mathematical equations can be used as effectual tools in drug delivery systems modeling and are also highly helpful to have a theoretical understanding of controlled drug release and diffusion mechanisms. In this study we aim to present a…

Tissues and Organs · Quantitative Biology 2019-02-18 Ali Esmaeili , Saeed Ranjbar

Herein an alternative model to reptation to describe concentrated polymer dynamics is developed. The model assumes that the chains act as blobs that are able to diffuse past each other in a compressed state. Allowing that the local…

Soft Condensed Matter · Physics 2022-02-25 Dave E. Dunstan

Effective and controlled drug delivery systems with on-demand release and targeting abilities have received enormous attention for biomedical applications. Here, we describe a novel enzyme-based cap system for mesoporous silica…

Chemically functionalized single-walled carbon nanotubes (SWNTs) have shown promise in tumor targeted accumulation in mice and exhibit biocompatibility, excretion and little toxicity. Here, we demonstrate in-vivo SWNT drug delivery for…

Materials Science · Physics 2008-08-26 Zhuang Liu , Kai Chen , Corrine Davis , Sarah Sherlock , Qizhen Cao , Xiaoyuan Chen , Hongjie Dai

Improving building energy performance requires the development of new highly insulative materials. An affordable retrofitting solution comprising a thin film could improve the resistance to heat flow in both residential and commercial…

As an example for the interplay of structure, dynamics, and phase behavior of macromolecular systems, this article focuses on the problem of bottle-brush polymers with either rigid or flexible backbones. On a polymer with chain length…

Soft Condensed Matter · Physics 2009-10-23 Hsiao-Ping Hsu , Wolfgang Paul , Panagiotis E. Theodorakis , Kurt Binder

The pursuit of targeted therapies capable of overcoming biological barriers, including the tenacious blood-brain barrier, has spurred the investigation into stimuli-responsive microagents. This approach could improve therapeutic efficacy,…

Bio-inspired molecular communications (MC), where molecules are used to transfer information, is the most promising technique to realise the Internet of Nano Things (IoNT), thanks to its inherent biocompatibility, energy-efficiency, and…

Emerging Technologies · Computer Science 2020-07-07 Murat Kuscu , Hamideh Ramezani , Ergin Dinc , Shahab Akhavan , Ozgur B. Akan

Nanofibrillated cellulose, a polymer that can be obtained from one of the most abundant biopolymers in Nature, is being increasingly explored due to its outstanding properties for packaging and device applications. Still, open challenges in…