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Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit. Relying on either four primitive bases or independently…

Genomics · Quantitative Biology 2025-11-20 Siyuan Li , Kai Yu , Anna Wang , Zicheng Liu , Chang Yu , Jingbo Zhou , Qirong Yang , Yucheng Guo , Xiaoming Zhang , Stan Z. Li

Decoding neural visual representations from electroencephalogram (EEG)-based brain activity is crucial for advancing brain-machine interfaces (BMI) and has transformative potential for neural sensory rehabilitation. While multimodal…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Yueyang Li , Zijian Kang , Shengyu Gong , Wenhao Dong , Weiming Zeng , Hongjie Yan , Wai Ting Siok , Nizhuan Wang

Single-cell RNA sequencing (scRNA-seq) data is a potent tool for comprehending the "language of life" and can provide insights into various downstream biomedical tasks. Large-scale language models (LLMs) are starting to be used for cell…

Computational Engineering, Finance, and Science · Computer Science 2023-06-08 Suyuan Zhao , Jiahuan Zhang , Zaiqing Nie

BERT adopts masked language modeling (MLM) for pre-training and is one of the most successful pre-training models. Since BERT neglects dependency among predicted tokens, XLNet introduces permuted language modeling (PLM) for pre-training to…

Computation and Language · Computer Science 2020-11-03 Kaitao Song , Xu Tan , Tao Qin , Jianfeng Lu , Tie-Yan Liu

While encoder-only models such as BERT and ModernBERT are ubiquitous in real-world NLP applications, their conventional reliance on task-specific classification heads can limit their applicability compared to decoder-based large language…

Computation and Language · Computer Science 2025-02-11 Benjamin Clavié , Nathan Cooper , Benjamin Warner

Masked language modeling (MLM) has become one of the most successful self-supervised pre-training task. Inspired by its success, Point-BERT, as a pioneer work in point cloud, proposed masked point modeling (MPM) to pre-train point…

Computer Vision and Pattern Recognition · Computer Science 2022-08-16 Kexue Fu , Mingzhi Yuan , Manning Wang

Due to the significant variability in electroencephalo-gram (EEG) signals across individuals, knowledge acquired from previous subjects is often overwritten as new subjects are introduced in continual EEG decoding tasks. Existing methods…

Machine Learning · Computer Science 2026-01-16 Dan Li , Hye-Bin Shin , Yeon-Woo Choi

Deep learning associated with neurological signals is poised to drive major advancements in diverse fields such as medical diagnostics, neurorehabilitation, and brain-computer interfaces. The challenge in harnessing the full potential of…

Signal Processing · Electrical Eng. & Systems 2024-07-08 Di Wu , Siyuan Li , Jie Yang , Mohamad Sawan

Transformer-based models generally allocate the same amount of computation for each token in a given sequence. We develop a simple but effective "token dropping" method to accelerate the pretraining of transformer models, such as BERT,…

Computation and Language · Computer Science 2022-03-25 Le Hou , Richard Yuanzhe Pang , Tianyi Zhou , Yuexin Wu , Xinying Song , Xiaodan Song , Denny Zhou

Learning code representations has been the core prerequisite of many software engineering tasks such as code clone detection and code generation. State-of-the-art program representation techniques mainly utilize pre-trained language models…

Software Engineering · Computer Science 2024-04-16 Nan Cui , Xiaodong Gu , Beijun Shen

Neural sequence labeling (NSL) aims at assigning labels for input language tokens, which covers a broad range of applications, such as named entity recognition (NER) and slot filling, etc. However, the satisfying results achieved by…

Computation and Language · Computer Science 2023-02-20 Jianing Wang , Chengyu Wang , Jun Huang , Ming Gao , Aoying Zhou

Foundation models have made significant strides in understanding the genomic language of DNA sequences. However, previous models typically adopt the tokenization methods designed for natural language, which are unsuitable for DNA sequences…

Genomics · Quantitative Biology 2024-12-19 Lifeng Qiao , Peng Ye , Yuchen Ren , Weiqiang Bai , Chaoqi Liang , Xinzhu Ma , Nanqing Dong , Wanli Ouyang

Pre-trained Language Models (PLMs) have achieved great success on Machine Reading Comprehension (MRC) over the past few years. Although the general language representation learned from large-scale corpora does benefit MRC, the poor support…

Computation and Language · Computer Science 2021-05-19 Fangkai Jiao , Yangyang Guo , Yilin Niu , Feng Ji , Feng-Lin Li , Liqiang Nie

Single-cell RNA sequencing has transformed our ability to identify diverse cell types and their transcriptomic signatures. However, annotating these signatures-especially those involving poorly characterized genes-remains a major challenge.…

We introduce Nuclear Co-Learned Representations (NuCLR), a deep learning model that predicts various nuclear observables, including binding and decay energies, and nuclear charge radii. The model is trained using a multi-task approach with…

Fine-tuning Large Language Models (LLMs) is now a common approach for text classification in a wide range of applications. When labeled documents are scarce, active learning helps save annotation efforts but requires retraining of massive…

Machine Learning · Computer Science 2024-02-27 Artem Vysogorets , Achintya Gopal

In the global challenge of understanding and characterizing biodiversity, short species-specific genomic sequences known as DNA barcodes play a critical role, enabling fine-grained comparisons among organisms within the same kingdom of…

We present CodeBERT, a bimodal pre-trained model for programming language (PL) and nat-ural language (NL). CodeBERT learns general-purpose representations that support downstream NL-PL applications such as natural language codesearch, code…

Computation and Language · Computer Science 2020-09-21 Zhangyin Feng , Daya Guo , Duyu Tang , Nan Duan , Xiaocheng Feng , Ming Gong , Linjun Shou , Bing Qin , Ting Liu , Daxin Jiang , Ming Zhou

Language model pre-training based on large corpora has achieved tremendous success in terms of constructing enriched contextual representations and has led to significant performance gains on a diverse range of Natural Language…

Computation and Language · Computer Science 2021-08-04 Weidong Guo , Mingjun Zhao , Lusheng Zhang , Di Niu , Jinwen Luo , Zhenhua Liu , Zhenyang Li , Jianbo Tang

Protein language models (PLMs) encode rich biological information, yet their internal neuron representations are poorly understood. We introduce the first automated framework for labeling every neuron in a PLM with biologically grounded…

Machine Learning · Computer Science 2025-07-10 Arjun Banerjee , David Martinez , Camille Dang , Ethan Tam
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