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Background and Objective: This proof of concept study investigates mathematical modelling of blood flow and oxygen transport in cerebral microcirculation, focusing on understanding hemodynamic responses. By coupling oxygen transport models…
Delineating 3D blood vessels is essential for clinical diagnosis and treatment, however, is challenging due to complex structure variations and varied imaging conditions. Supervised deep learning has demonstrated its superior capacity in…
Flow of cerebrospinal fluid in perivascular spaces is a key mechanism underlying brain transport and clearance. In this paper, we present a mathematical and numerical formalism for reduced models of pulsatile viscous fluid flow in networks…
Background: Cardiovascular diseases (CVDs) are among the leading causes of death worldwide. Predictive scores providing personalised risk of developing CVD are increasingly used in clinical practice. Most scores, however, utilise a…
The study of vesicles under flow, a model system for red blood cells (RBCs), is an essential step in understanding various intricate dynamics exhibited by RBCs in vivo and in vitro. Quantitative 3D analyses of vesicles under flow are…
Photoplethysmography (PPG) is emerging as a crucial tool for monitoring human hemodynamics, with recent studies highlighting its potential in assessing vascular aging through deep learning. However, real-world age distributions are often…
Our knowledge of the organisation of the human brain at the population-level is yet to translate into power to predict functional differences at the individual-level, limiting clinical applications, and casting doubt on the generalisability…
Blood circulation in the human brain is supplied through a network of cerebral arteries. If a clinician suspects a patient has a stroke or other cerebrovascular condition they order imaging tests. Neuroradiologists visually search the…
Diffusion-weighted magnetic resonance imaging (DW-MRI) is a critical imaging method for capturing and modeling tissue microarchitecture at a millimeter scale. A common practice to model the measured DW-MRI signal is via fiber orientation…
Adequate brain perfusion is required for proper brain function and life. Maintaining optimal brain perfusion to avoid secondary brain injury is one of the main concerns of neurocritical care. Cerebral autoregulation is responsible for…
In recent decades, the use of 4D Flow MRI images has enabled the quantification of velocity fields within a volume of interest and along the cardiac cycle. However, the lack of resolution and the presence of noise in these biomarkers are…
A network-based approach is presented to investigate the cerebrovascular flow patterns during atrial fibrillation (AF) with respect to normal sinus rhythm (NSR). AF, the most common cardiac arrhythmia with faster and irregular beating, has…
Familial cerebral cavernous malformation (FCCM) is a hereditary disorder characterized by abnormal vascular structures within the central nervous system. The FCCM lesions are often numerous and intricate, making quantitative analysis of the…
Cerebral aneurysm rupture, leading to subarachnoid hemorrhage with a high mortality rate, disproportionately affects younger populations, resulting in a significant loss of productive life years. A significant proportion of these deaths is…
Arterial Spin Labelling (ASL) functional Magnetic Resonance Imaging (fMRI) data provides a quantitative measure of blood perfusion, that can be correlated to neuronal activation. In contrast to BOLD measure, it is a direct measure of…
Computational fluid dynamics (CFD) is a valuable tool for personalised, non-invasive evaluation of hemodynamics in arteries, but its complexity and time-consuming nature prohibit large-scale use in practice. Recently, the use of deep…
Preterm birth disrupts the typical trajectory of cortical neurodevelopment, increasing the risk of cognitive and behavioral difficulties. However, outcomes vary widely, posing a significant challenge for early prediction. To address this,…
We introduce a rapid and precise analytical approach for analyzing cerebral blood flow (CBF) using Diffuse Correlation Spectroscopy (DCS) with the application of the Extreme Learning Machine (ELM). Our evaluation of ELM and existing…
The purpose of this study is to enable in-vivo three-dimensional (3-D) ultrasound localization microscopy (ULM) of posterior ocular microvasculature using a 256-channel system and a 1024-element matrix array, and to overcome limitations of…
We propose a control barrier function (CBF) formulation for enforcing equality and inequality constraints in variational inference. The key idea is to define a barrier functional on the space of probability density functions that encode the…