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Brain aging, and more specifically the difference between the chronological and the biological age of a person, may be a promising biomarker for identifying neurodegenerative diseases. For this purpose accurate prediction is important but…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Kyriaki-Margarita Bintsi , Vasileios Baltatzis , Alexander Hammers , Daniel Rueckert

Computational fluid dynamics (CFD) is a valuable asset for patient-specific cardiovascular-disease diagnosis and prognosis, but its high computational demands hamper its adoption in practice. Machine-learning methods that estimate blood…

Machine Learning · Computer Science 2024-06-18 Julian Suk , Pim de Haan , Phillip Lippe , Christoph Brune , Jelmer M. Wolterink

Cardiovascular disease (CVD) cohort studies collect longitudinal data on numerous CVD risk factors including body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, and total cholesterol. The commonly…

Methodology · Statistics 2025-06-24 Mirajul Islam , Michael J. Daniels , Juned Siddique

The fundamentals of near infrared spectroscopy (NIRS) are reviewed. Among the major factors controlling the cerebral blood flow (CBF), the effect of PaCO2 is peculiar in that it violates autoregulatory CBF mechanisms and allows to explore…

Medical Physics · Physics 2015-10-20 Alexander Gersten

Background and Objective: Hemodynamic analysis of blood flow through arteries and veins is critical for diagnosing cardiovascular diseases, such as aneurysms and stenoses, and for investigating cardiovascular parameters, such as turbulence…

Purpose: The purpose of this study was to observe change in accuracies of convolutional neural networks (CNN) models (ratio of correct classifications to total predictions) on thoracic radiological images by creating different binary…

Image and Video Processing · Electrical Eng. & Systems 2019-12-03 Mir Muhammad Abdullah , Mir Muhammad Abdur Rahman , Mir Mohammed Assadullah

Multi-layer diffuse correlation spectroscopy (DCS) models have been developed to reduce the contamination of superficial signals in cerebral blood flow index (CBFi) measurements. However, a systematic comparison of these models and clear…

Medical Physics · Physics 2025-07-30 Mingliang Pan , Quan Wang , Yuanzhe Zhang , David Day-Uei Li

Due to the lack of automated methods, to diagnose cerebrovascular disease, time-of-flight magnetic resonance angiography (TOF-MRA) is assessed visually, making it time-consuming. The commonly used encoder-decoder architectures for…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Syed Farhan Abbas , Nguyen Thanh Duc , Yoonguu Song , Kyungwon Kim , Ekta Srivastava , Boreom Lee

Diffusion functional MRI (dfMRI) is a promising technique to map functional activations by acquiring diffusion-weighed spin-echo images. In previous studies, dfMRI showed higher spatial accuracy at activation mapping compared to classic…

Medical Physics · Physics 2019-08-15 Alberto De Luca , Lara Schlaffke , Jeroen CW Siero , Martijn Froeling , Alexander Leemans

Mapping blood microflows of the whole brain is crucial for early diagnosis of cerebral diseases. Ultrasound localization microscopy (ULM) was recently applied to map and quantify blood microflows in 2D in the brain of adult patients down to…

Medical Physics · Physics 2023-04-12 Hugues Favre , Mathieu Pernot , Mickael Tanter , Clément Papadacci

Accurate quantification of cerebral blood flow (CBF) is essential for the diagnosis and assessment of cerebrovascular diseases such as Moyamoya, carotid stenosis, aneurysms, and stroke. Positron emission tomography (PET) is currently…

Image and Video Processing · Electrical Eng. & Systems 2022-02-15 Ramy Hussein , Moss Zhao , David Shin , Jia Guo , Kevin T. Chen , Rui D. Armindo , Guido Davidzon , Michael Moseley , Greg Zaharchuk

Purpose: To simulate the intravoxel incoherent perfusion magnetic resonance magnitude signal from the motion of blood particles in three realistic vascular network graphs from a mouse brain. Methods: In three networks generated from the…

Medical Physics · Physics 2021-01-01 Valerie Phi van , Franca Schmid , Georg Spinner , Sebastian Kozerke , Christian Federau

Many studies regarding the vasculature of biological tissues involve the segmentation of the blood vessels in a sample followed by the creation of a graph structure to model the vasculature. The graph is then used to extract relevant…

Computer Vision and Pattern Recognition · Computer Science 2024-06-21 João Pedro Parella , Matheus Viana da Silva , Cesar Henrique Comin

To address many of the deficiencies in optical neuroimaging technologies such as poor spatial resolution, time-consuming reconstruction, low penetration depth, and contact-based measurement, a novel, noncontact, time-resolved laser speckle…

Timely, accurate and reliable assessment of fetal brain development is essential to reduce short and long-term risks to fetus and mother. Fetal MRI is increasingly used for fetal brain assessment. Three key biometric linear measurements…

Image and Video Processing · Electrical Eng. & Systems 2022-06-30 Netanell Avisdris , Bossmat Yehuda , Ori Ben-Zvi , Daphna Link-Sourani , Liat Ben-Sira , Elka Miller , Elena Zharkov , Dafna Ben Bashat , Leo Joskowicz

Hemodynamics in the aorta from computational fluid dynamics (CFD) simulations can provide a comprehensive analysis of relevant cardiovascular diseases. Coupling the three-element Windkessel model with the patient-specific CFD simulation to…

Fluid Dynamics · Physics 2022-07-14 Zongze Li , Wenbin Mao

Quantification of myocardial perfusion has the potential to improve detection of regional and global flow reduction. Significant effort has been made to automate the workflow, where one essential step is the arterial input function (AIF)…

Quantitative Methods · Quantitative Biology 2020-05-11 Hui Xue , Ethan Tseng , Kristopher D Knott , Tushar Kotecha , Louise Brown , Sven Plein , Marianna Fontana , James C Moon , Peter Kellman

Accurate fetal brain segmentation is crucial for extracting biomarkers and assessing neurodevelopment, especially in conditions such as corpus callosum dysgenesis (CCD), which can induce drastic anatomical changes. However, the rarity of…

Computer Vision and Pattern Recognition · Computer Science 2025-10-03 Marina Grifell i Plana , Vladyslav Zalevskyi , Léa Schmidt , Yvan Gomez , Thomas Sanchez , Vincent Dunet , Mériam Koob , Vanessa Siffredi , Meritxell Bach Cuadra

Accurate and rapid estimation of hemodynamic metrics, such as pressure and wall shear stress (WSS), is important for assessing the severity of Coronary Artery Disease (CAD). Existing approaches, including invasive Fractional Flow Reserve…

Computational Engineering, Finance, and Science · Computer Science 2026-05-28 Reza Akbarian Bafghi , Sukirt Thakur , Maziar Raissi

MR vascular Fingerprinting proposes to use the MR Fingerprinting framework to quantitatively and simultaneously map several microvascular characteristics at a sub-voxel scale. The initial implementation assessed the local blood oxygenation…

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