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Firms increasingly use randomized experiments to decide whether to scale up an intervention and, if so, how to re-optimize related operational choices such as inventory, capacity, or pricing. In many settings, experiments are performed on…

Methodology · Statistics 2026-03-12 Guoxing He , Dan Yang , Wei Zhang

A century ago, Neyman showed how to evaluate the efficacy of treatment using a randomized experiment under a minimal set of assumptions. This classical repeated sampling framework serves as a basis of routine experimental analyses conducted…

Methodology · Statistics 2024-04-29 Michael Lingzhi Li , Kosuke Imai

Integrative analysis of multiple datasets for estimating optimal individualized treatment rules (ITRs) can enhance decision efficiency. A central challenge is posterior shift, wherein the conditional distribution of potential outcomes given…

Machine Learning · Statistics 2026-03-09 Wenhai Cui , Wen Su , Xingqiu Zhao

Randomized experiments have been the gold standard for assessing the effectiveness of a treatment or policy. The classical complete randomization approach assigns treatments based on a prespecified probability and may lead to inefficient…

Methodology · Statistics 2023-10-26 Waverly Wei , Xinwei Ma , Jingshen Wang

Platform trials have become increasingly popular for drug development programs, attracting interest from statisticians, clinicians and regulatory agencies. Many statistical questions related to designing platform trials - such as the impact…

Ensuring the generalisability of clinical machine learning (ML) models across diverse healthcare settings remains a significant challenge due to variability in patient demographics, disease prevalence, and institutional practices. Existing…

Machine Learning · Computer Science 2025-04-30 Bradley Segal , Joshua Fieggen , David Clifton , Lei Clifton

Clinicians and researchers alike are increasingly interested in how best to personalize interventions. A dynamic treatment regimen (DTR) is a sequence of pre-specified decision rules which can be used to guide the delivery of a sequence of…

In recent years, there has been a surge in the development of models for the generation of synthetic mobility data. These models aim to facilitate the sharing of data while safeguarding privacy, all while ensuring high utility and…

Cryptography and Security · Computer Science 2024-07-04 Alexandra Kapp , Helena Mihaljević

Individualized treatment rules/recommendations (ITRs) aim to improve patient outcomes by tailoring treatments to the characteristics of each individual. However, when there are many treatment groups, existing methods face significant…

Methodology · Statistics 2025-05-27 Ke Zhu , Jianing Chu , Ilya Lipkovich , Wenyu Ye , Shu Yang

A platform trial with a master protocol provides an infrastructure to ethically and efficiently evaluate multiple treatment options in multiple diseases. Given that certain study drugs can enter or exit a platform trial, the randomization…

Methodology · Statistics 2025-07-15 Tianyu Zhan , Jane Zhang , Lei Shu , Yihua Gu

Dataset distillation (DD) is an increasingly important technique that focuses on constructing a synthetic dataset capable of capturing the core information in training data to achieve comparable performance in models trained on the latter.…

Machine Learning · Computer Science 2024-09-04 Vyacheslav Kungurtsev , Yuanfang Peng , Jianyang Gu , Saeed Vahidian , Anthony Quinn , Fadwa Idlahcen , Yiran Chen

Synthesizing information from multiple data sources is crucial for constructing accurate individualized treatment rules (ITRs). However, privacy concerns often present significant barriers to the integrative analysis of such multi-source…

Methodology · Statistics 2025-11-11 Nan Qiao , Wangcheng Li , Jingxiao Zhang , Canyi Chen

Synthetic data offers a promising solution to the privacy and accessibility challenges of using smart card data in public transport research. Despite rapid progress in generative modeling, there is limited attention to comprehensive…

Machine Learning · Computer Science 2025-10-29 Yuanyuan Wu , Zhenlin Qin , Zhenliang Ma

Histopathology can help clinicians make accurate diagnoses, determine disease prognosis, and plan appropriate treatment strategies. As deep learning techniques prove successful in the medical domain, the primary challenges become limited…

Computer Vision and Pattern Recognition · Computer Science 2024-07-11 Zhe Li , Bernhard Kainz

Individualized treatment decisions can improve health outcomes, but using data to make these decisions in a reliable, precise, and generalizable way is challenging with a single dataset. Leveraging multiple randomized controlled trials…

The inherent capabilities of a language model (LM) and the reasoning strategies it employs jointly determine its performance in reasoning tasks. While test-time scaling is regarded as an effective approach to tackling complex reasoning…

Computation and Language · Computer Science 2025-05-27 Zhihong Pan , Kai Zhang , Yuze Zhao , Yupeng Han

Click-through rate (CTR) prediction plays a crucial role in modern recommender systems. While many existing methods utilize ensemble networks to improve CTR model performance, they typically restrict the ensemble to only two or three…

Information Retrieval · Computer Science 2025-06-23 Honghao Li , Lei Sang , Yi Zhang , Guangming Cui , Yiwen Zhang

Data-driven predictive control (DDPC) has been recently proposed as an effective alternative to traditional model-predictive control (MPC) for its unique features of being time-efficient and unbiased with respect to the oracle solution.…

Systems and Control · Electrical Eng. & Systems 2022-11-22 Valentina Breschi , Alessandro Chiuso , Simone Formentin

Estimating heterogeneous treatment effects is central to data-driven decision-making, yet industrial applications often face a fundamental tension between limited randomized controlled trial (RCT) budgets and abundant but biased…

Identifying relationships between molecular variations and their clinical presentations has been challenged by the heterogeneous causes of a disease. It is imperative to unveil the relationship between the high dimensional molecular…

Methodology · Statistics 2021-09-02 Wennan Chang , Changlin Wan , Yong Zang , Chi Zhang , Sha Cao