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Active transport of biomolecular condensates and cell migration in collectives are fundamental to development, homeostasis, and processes such as cancer progression, wound healing, and infection response. Yet how these assemblies are…

Soft Condensed Matter · Physics 2025-10-24 Hossein Vahid , Jens-Uwe Sommer , Abhinav Sharma

We investigate the nonequilibrium dynamics of active matter using a two-dimensional active Brownian particles model. In these systems, self-propelled particles undergo motility-induced phase separation (MIPS), spontaneously segregating into…

Soft Condensed Matter · Physics 2026-02-26 Toranosuke Umemura , Issei Sakai , Takuma Akimoto

We use a continuum model to examine the effect of activity on a phase separating mixture of an extensile active nematic and a passive fluid. We highlight the distinct role of previously considered interfacial active stresses and bulk active…

Soft Condensed Matter · Physics 2022-12-26 Fernando Caballero , M. Cristina Marchetti

Phase separation, the spontaneous segregation of density, is a ubiquitous phenomenon observed across diverse physical and biological systems. Within a crowd of motile elements, active phase separation emerges from the interplay of activity…

Soft Condensed Matter · Physics 2026-01-26 Kyosuke Adachi

Liquid-liquid phase separation has emerged as a fundamental mechanism underlying intracellular organization, with evidence for it being reported in numerous different systems. However, there is a growing concern regarding the lack of…

Soft Condensed Matter · Physics 2022-12-09 Mrityunjay Kothari , Tal Cohen

The cellular environment, characterized by its intricate composition and spatial organization, hosts a variety of organelles, ranging from membrane-bound ones to membraneless structures that are formed through liquid-liquid phase…

Soft Condensed Matter · Physics 2026-03-09 Gregor Häfner , Marcus Müller

Cells control the size and organization of biomolecular condensates formed by liquid-liquid phase separation (LLPS), but multiple mechanisms likely contribute to this control and remain to be fully elucidated. Here we propose a…

Biological Physics · Physics 2026-04-10 Le Qiao , Peter Gispert , Lukas S. Stelzl , Friederike Schmid

Self-propelled particles phase separate into coexisting dense and dilute regions above a critical density. The statistical nature of their stochastic motion lends itself to various theories that predict the onset of phase separation.…

Soft Condensed Matter · Physics 2018-04-25 Isaac R. Bruss , Sharon C. Glotzer

Phase separation of various materials has been studied for one and a half centuries. In the last two decades, phase separation of proteins and nucleic acids has received enormous attention, due its relevance to cellular functions. However,…

Soft Condensed Matter · Physics 2026-05-28 Huan-Xiang Zhou

We study numerically a model of non-aligning self-propelled particles interacting through steric repulsion, which was recently shown to exhibit active phase separation in two dimensions in the absence of any attractive interaction or…

Soft Condensed Matter · Physics 2014-06-03 Yaouen Fily , Silke Henkes , M. Cristina Marchetti

We study binary mixtures of small active and big passive athermal particles interacting via soft repulsive forces on a frictional substrate. Athermal self propelled particles are known to phase separate into a dense aggregate and a dilute…

Soft Condensed Matter · Physics 2018-07-05 Pritha Dolai , Aditi Simha , Shradha Mishra

Non-equilibrium selection pressures were proposed for the formation of oligonucleotides with rich functionalities encoded in their sequences, such as catalysis. Since phase separation was shown to direct various chemical processes, we ask…

Statistical Mechanics · Physics 2024-10-14 Ivar S. Haugerud , Giacomo Bartolucci , Dieter Braun , Christoph A. Weber

We study chemical oscillators in the presence of phase separation. By imposing timescale separation between slow reactions and fast diffusion, we define a dynamics at phase equilibrium for the relevant degrees of freedom. We demonstrate…

Soft Condensed Matter · Physics 2025-07-23 Jonathan Bauermann , Giacomo Bartolucci , Artemy Kolchinsky

In living and engineered systems of active particles, self-propulsion induces an unjamming transition from a solid to a fluid phase and phase separation between a gas and a liquid-like phase. We demonstrate an interplay between these two…

Soft Condensed Matter · Physics 2022-07-20 Jing Yang , Ran Ni , Massimo Pica Ciamarra

Motility-induced phase separation (MIPS) arises generically in fluids of self-propelled particles when interactions lead to a kinetic slowdown at high densities. Starting from a continuum description of scalar active matter, akin to a…

Statistical Mechanics · Physics 2018-02-28 Alexandre P. Solon , Joakim Stenhammar , Michael E. Cates , Yariv Kafri , Julien Tailleur

We study numerically and analytically a model of self-propelled polar disks on a substrate in two dimensions. The particles interact via isotropic repulsive forces and are subject to rotational noise, but there is no aligning interaction.…

Soft Condensed Matter · Physics 2014-02-24 Yaouen Fily , M. Cristina Marchetti

The appearance of emergent symmetries in complex systems with components that can form composite units provides us with opportunities for design and control of exotic phase behaviour, for example by exploiting the dynamical symmetry…

Soft Condensed Matter · Physics 2026-03-24 Jakob Metson , Ramin Golestanian

In addition to self-propulsion by phoretic mechanisms that arises from an asymmetric distribution of reactive species around a catalytic motor, spherical particles with a uniform distribution of catalytic activity may also propel themselves…

Statistical Mechanics · Physics 2014-01-08 Pierre de Buyl , Alexander S. Mikhailov , Raymond Kapral

Enzyme-enriched condensates can organize the spatial distribution of their substrates by catalyzing non-equilibrium reactions. Conversely, an inhomogeneous substrate distribution induces enzyme fluxes through substrate-enzyme interactions.…

Biological Physics · Physics 2023-03-29 Leonardo Demarchi , Andriy Goychuk , Ivan Maryshev , Erwin Frey

Droplet formation has emerged as an essential concept for the spatiotemporal organisation of biomolecules in cells. However, classical descriptions of droplet dynamics based on passive liquid-liquid phase separation cannot capture the…

Biological Physics · Physics 2025-11-14 David Zwicker , Oliver W. Paulin , Cathelijne ter Burg