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The detection of nuclei is one of the most fundamental components of computational pathology. Current state-of-the-art methods are based on deep learning, with the prerequisite that extensive labeled datasets are available. The increasing…

Image and Video Processing · Electrical Eng. & Systems 2019-07-11 Nicolas Brieu , Armin Meier , Ansh Kapil , Ralf Schoenmeyer , Christos G. Gavriel , Peter D. Caie , Günter Schmidt

Despite notable advancements, the integration of deep learning (DL) techniques into impactful clinical applications, particularly in the realm of digital histopathology, has been hindered by challenges associated with achieving robust…

Image and Video Processing · Electrical Eng. & Systems 2024-07-04 Sebastian Doerrich , Francesco Di Salvo , Christian Ledig

Generalization to previously unseen images with potential domain shifts and different styles is essential for clinically applicable medical image segmentation, and the ability to disentangle domain-specific and domain-invariant features is…

Computer Vision and Pattern Recognition · Computer Science 2022-11-23 Ran Gu , Guotai Wang , Jiangshan Lu , Jingyang Zhang , Wenhui Lei , Yinan Chen , Wenjun Liao , Shichuan Zhang , Kang Li , Dimitris N. Metaxas , Shaoting Zhang

Domain generalization aims to enhance the model robustness against domain shift without accessing the target domain. Since the available source domains for training are limited, recent approaches focus on generating samples of novel…

Computer Vision and Pattern Recognition · Computer Science 2021-08-20 Seogkyu Jeon , Kibeom Hong , Pilhyeon Lee , Jewook Lee , Hyeran Byun

An increasing number of classification approaches have been developed to address the issue of image rebroadcast and recapturing, a standard attack strategy in insurance frauds, face spoofing, and video piracy. However, most of them…

Computer Vision and Pattern Recognition · Computer Science 2024-07-26 Preeti Mehta , Aman Sagar , Suchi Kumari

Digital pathology is revolutionizing the field of pathology by enabling the digitization, storage, and analysis of tissue samples as whole slide images (WSIs). WSIs are gigapixel files that capture the intricate details of tissue samples,…

Image and Video Processing · Electrical Eng. & Systems 2024-09-10 S. Hemati , Krishna R. Kalari , H. R. Tizhoosh

The success of deep learning has set new benchmarks for many medical image analysis tasks. However, deep models often fail to generalize in the presence of distribution shifts between training (source) data and test (target) data. One…

Image and Video Processing · Electrical Eng. & Systems 2022-06-28 Dwarikanath Mahapatra

Domain shift is a critical problem for pathology AI as pathology data is heavily influenced by center-specific conditions. Current pathology domain adaptation methods focus on image patches rather than WSI, thus failing to capture global…

Artificial Intelligence · Computer Science 2025-08-11 Jingsong Liu , Han Li , Chen Yang , Michael Deutges , Ario Sadafi , Xin You , Katharina Breininger , Nassir Navab , Peter J. Schüffler

Medical image segmentation plays a crucial role in clinical workflows, but domain shift often leads to performance degradation when models are applied to unseen clinical domains. This challenge arises due to variations in imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Yingkai Wang , Yaoyao Zhu , Xiuding Cai , Yuhao Xiao , Haotian Wu , Yu Yao

Histopathology whole slide images (WSIs) can reveal significant inter-hospital variability such as illumination, color or optical artifacts. These variations, caused by the use of different scanning protocols across medical centers…

Computer Vision and Pattern Recognition · Computer Science 2022-07-01 Marin Scalbert , Maria Vakalopoulou , Florent Couzinié-Devy

Domain generalisation (DG) methods address the problem of domain shift, when there is a mismatch between the distributions of training and target domains. Data augmentation approaches have emerged as a promising alternative for DG. However,…

Machine Learning · Computer Science 2020-12-29 Hoang Son Le , Rini Akmeliawati , Gustavo Carneiro

Deep learning methods such as convolutional neural networks (CNNs) are difficult to directly utilize to analyze whole slide images (WSIs) due to the large image dimensions. We overcome this limitation by proposing a novel two-stage…

Image and Video Processing · Electrical Eng. & Systems 2021-06-15 Shivam Kalra , Mohammed Adnan , Sobhan Hemati , Taher Dehkharghanian , Shahryar Rahnamayan , Hamid Tizhoosh

Digital pathological analysis is run as the main examination used for cancer diagnosis. Recently, deep learning-driven feature extraction from pathology images is able to detect genetic variations and tumor environment, but few studies…

Computer Vision and Pattern Recognition · Computer Science 2022-04-28 Haojie Huang , Gongming Zhou , Xuejun Liu , Lei Deng , Chen Wu , Dachuan Zhang , Hui Liu

Single source domain generalization (SDG) holds promise for more reliable and consistent image segmentation across real-world clinical settings particularly in the medical domain, where data privacy and acquisition cost constraints often…

Computer Vision and Pattern Recognition · Computer Science 2024-04-04 Shahina Kunhimon , Muzammal Naseer , Salman Khan , Fahad Shahbaz Khan

Medical images from different healthcare centers exhibit varied data distributions, posing significant challenges for adapting lung nodule detection due to the domain shift between training and application phases. Traditional unsupervised…

Computer Vision and Pattern Recognition · Computer Science 2024-08-05 Haifeng Zhao , Lixiang Jiang , Leilei Ma , Dengdi Sun , Yanping Fu

Deep learning models usually suffer from domain shift issues, where models trained on one source domain do not generalize well to other unseen domains. In this work, we investigate the single-source domain generalization problem: training a…

Computer Vision and Pattern Recognition · Computer Science 2023-04-24 Cheng Ouyang , Chen Chen , Surui Li , Zeju Li , Chen Qin , Wenjia Bai , Daniel Rueckert

Recently, we have witnessed great progress in the field of medical imaging classification by adopting deep neural networks. However, the recent advanced models still require accessing sufficiently large and representative datasets for…

Computer Vision and Pattern Recognition · Computer Science 2020-10-30 Haoliang Li , YuFei Wang , Renjie Wan , Shiqi Wang , Tie-Qiang Li , Alex C. Kot

Domain-invariant representation learning is a powerful method for domain generalization. Previous approaches face challenges such as high computational demands, training instability, and limited effectiveness with high-dimensional data,…

Computer Vision and Pattern Recognition · Computer Science 2024-11-25 Yuheng Xu , Taiping Zhang

Semi-supervised learning (SSL), which aims at leveraging a few labeled images and a large number of unlabeled images for network training, is beneficial for relieving the burden of data annotation in medical image segmentation. According to…

Image and Video Processing · Electrical Eng. & Systems 2022-02-15 Xinkai Zhao , Chaowei Fang , De-Jun Fan , Xutao Lin , Feng Gao , Guanbin Li

Lesion detection is a fundamental problem in the computer-aided diagnosis scheme for mammography. The advance of deep learning techniques have made a remarkable progress for this task, provided that the training data are large and…

Image and Video Processing · Electrical Eng. & Systems 2021-11-23 Zheren Li , Zhiming Cui , Sheng Wang , Yuji Qi , Xi Ouyang , Qitian Chen , Yuezhi Yang , Zhong Xue , Dinggang Shen , Jie-Zhi Cheng