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AI-based persona simulation -- often referred to as digital twin simulation -- is increasingly used for market research, recommender systems, and social sciences. Despite their flexibility, large language models (LLMs) often exhibit…

Machine Learning · Computer Science 2026-04-10 Grace Jiarui Fan , Chengpiao Huang , Tianyi Peng , Kaizheng Wang , Yuhang Wu

In this paper, we present a model free approach to calculate long-acting insulin doses for Type 2 Diabetic (T2D) subjects in order to bring their blood glucose (BG) concentration to be within a safe range. The proposed strategy tunes the…

Systems and Control · Electrical Eng. & Systems 2022-12-29 Mohamad Al Ahdab , Torben Knudsen , Jakob Stoustrup , John Leth

Deep Neural Networks (DNNs) are increasingly used in control applications due to their powerful function approximation capabilities. However, many existing formulations focus primarily on tracking error convergence, often neglecting the…

Systems and Control · Electrical Eng. & Systems 2025-05-19 Rebecca G. Hart , Omkar Sudhir Patil , Zachary I. Bell , Warren E. Dixon

Regular physical activity is known to be beneficial to people suffering from diabetes type 2. Nevertheless, most such people are sedentary. Smartphones create new possibilities for helping people to adhere to their physical activity goals,…

Computers and Society · Computer Science 2018-05-16 Irit Hochberg , Guy Feraru , Mark Kozdoba , Shie Mannor , Moshe Tennenholtz , Elad Yom-Tov

Non-invasive glucose monitoring outside controlled settings is dominated by low signal-to-noise ratio (SNR): hardware drift, environmental variation, and physiology suppress the glucose signature in NIR signals. We present a noise-stressed…

Image and Video Processing · Electrical Eng. & Systems 2026-02-23 Riyaadh Gani

Diabetes devices, including Continuous Glucose Monitoring (CGM), Smart Insulin Pens, and Automated Insulin Delivery systems, generate rich time-series data widely used in research and machine learning. However, inconsistent data formats…

Machine Learning · Computer Science 2026-04-15 Elliott C. Pryor , Marc D. Breton , Anas El Fathi

Network Digital Twins (NDTs) enable safe what-if analysis for 6G cloud-edge infrastructures, but adoption is often limited by fragmented workflows from telemetry to validation. We present a data-driven NDT framework that extends 6G-TWIN…

This paper presents the Derivatives Combination Predictor (DCP), a novel model fusion algorithm for making long-term glucose predictions for diabetic people. First, using the history of glucose predictions made by several models, the future…

Quantitative Methods · Quantitative Biology 2020-09-10 Maxime De Bois , Mounîm A. El Yacoubi , Mehdi Ammi

In the big data era, integrating diverse data modalities poses significant challenges, particularly in complex fields like healthcare. This paper introduces a new process model for multimodal Data Fusion for Data Mining, integrating…

Artificial Intelligence · Computer Science 2024-06-04 David Restrepo , Chenwei Wu , Constanza Vásquez-Venegas , Luis Filipe Nakayama , Leo Anthony Celi , Diego M López

Biosensor data has the potential ability to improve disease control and detection. However, the analysis of these data under free-living conditions is not feasible with current statistical techniques. To address this challenge, we introduce…

Applications · Statistics 2021-03-30 Marcos Matabuena , Alexander Petersen , Juan C. Vidal , Francisco Gude

Personal Health Systems (PHS) are mobile solutions tailored to monitoring patients affected by chronic non communicable diseases. A patient affected by a chronic disease can generate large amounts of events. Type 1 Diabetic patients…

Artificial Intelligence · Computer Science 2017-10-04 Stefano Bromuri , Albert Brugues de la Torre , Fabien Duboisson , Michael Schumacher

We introduce a novel methodology that leverages the strength of Physics-Informed Neural Networks (PINNs) to address the counterdiabatic (CD) protocol in the optimization of quantum circuits comprised of systems with $N_{Q}$ qubits. The…

Sustained high levels of blood glucose in type 2 diabetes (T2DM) can have disastrous long-term health consequences. An essential component of clinical interventions for T2DM is monitoring dietary intake to keep plasma glucose levels within…

Quantitative Methods · Quantitative Biology 2022-06-24 Zepeng Huo , Bobak J. Mortazavi , Theodora Chaspari , Nicolaas Deutz , Laura Ruebush , Ricardo Gutierrez-Osuna

The availability of continuous glucose monitors as over-the-counter commodities have created a unique opportunity to monitor a person's blood glucose levels, forecast blood glucose trajectories and provide automated interventions to prevent…

Machine Learning · Computer Science 2026-04-16 Ebrahim Farahmand , Shovito Barua Soumma , Nooshin Taheri Chatrudi , Hassan Ghasemzadeh

Digital twins offer a promising solution to the lack of sufficient labeled data in deep learning-based fault diagnosis by generating simulated data for model training. However, discrepancies between simulation and real-world systems can…

Machine Learning · Computer Science 2025-09-05 Zhenling Chen , Haiwei Fu , Zhiguo Zeng

We demonstrate an end-to-end framework to improve the resilience of man-made systems to unforeseen events. The framework is based on a physics-based digital twin model and three modules tasked with real-time fault diagnosis, prognostics and…

Artificial Intelligence · Computer Science 2022-09-01 Ion Matei , Wiktor Piotrowski , Alexandre Perez , Johan de Kleer , Jorge Tierno , Wendy Mungovan , Vance Turnewitsch

Continuous glucose monitoring (CGM) combined with AI offers new opportunities for proactive diabetes management through real-time glucose forecasting. However, most existing models are task-specific and lack generalization across patient…

Quantitative Methods · Quantitative Biology 2025-08-04 Junjie Luo , Abhimanyu Kumbara , Mansur Shomali , Rui Han , Anand Iyer , Ritu Agarwal , Gordon Gao

The concept of creating a virtual copy of a complete Cyber-Physical System opens up numerous possibilities, including real-time assessments of the physical environment and continuous learning from the system to provide reliable and precise…

Artificial Intelligence · Computer Science 2023-11-22 Carine Menezes Rebello , Johannes Jäschkea , Idelfonso B. R. Nogueira

We focus on the problem of generating high-quality, private synthetic glucose traces, a task generalizable to many other time series sources. Existing methods for time series data synthesis, such as those using Generative Adversarial…

Machine Learning · Computer Science 2023-11-01 Josephine Lamp , Mark Derdzinski , Christopher Hannemann , Joost van der Linden , Lu Feng , Tianhao Wang , David Evans

Continuous Glucose Monitoring (CGM) has enabled important opportunities for diabetes management. This study explores the use of CGM data as input for digital decision support tools. We investigate how Recurrent Neural Networks (RNNs) can be…