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The classification of diabetes and prediabetes by static glucose thresholds obscures the pathophysiological dysglycemia heterogeneity, primarily driven by insulin resistance (IR), beta-cell dysfunction, and incretin deficiency. This review…

Machine Learning · Computer Science 2025-11-07 Ahmed A. Metwally , Heyjun Park , Yue Wu , Tracey McLaughlin , Michael P. Snyder

Objective: Clinical implementation of deformable image registration (DIR) requires voxel-based spatial accuracy metrics such as manually identified landmarks, which are challenging to implement for highly mobile gastrointestinal (GI)…

Digital twin (DT) technology enables real-time simulation, prediction, and optimization of physical systems, but practical deployment faces challenges from high data requirements, proprietary data constraints, and limited adaptability to…

Motivation: There is a growing need to integrate mechanistic models of biological processes with computational methods in healthcare in order to improve prediction. We apply data assimilation in the context of Type 2 diabetes to understand…

Digital twins are transforming engineering and applied sciences by enabling real-time monitoring, simulation, and predictive analysis of physical systems and processes. However, conventional digital twins rely primarily on passive data…

Computational Engineering, Finance, and Science · Computer Science 2026-03-31 Matteo Torzoni , Domenico Maisto , Andrea Manzoni , Francesco Donnarumma , Giovanni Pezzulo , Alberto Corigliano

Digital twins promise to enhance robotic manipulation by maintaining a consistent link between real-world perception and simulation. However, most existing systems struggle with the lack of a unified model, complex dynamic interactions, and…

Robotics · Computer Science 2026-03-06 Yichen Cai , Paul Jansonnie , Cristiana de Farias , Oleg Arenz , Jan Peters

Obesity is a serious public health concern world-wide, which increases the risk of many diseases, including hypertension, stroke, and type 2 diabetes. To tackle this problem, researchers across the health ecosystem are collecting diverse…

Machine Learning · Computer Science 2018-09-24 Qinghan Xue , Xiaoran Wang , Samuel Meehan , Jilong Kuang , Alex Gao , Mooi Choo Chuah

Personalized virtual heart models have demonstrated increasing potential for clinical use, although the estimation of their parameters given patient-specific data remain a challenge. Traditional physics-based modeling approaches are…

Signal Processing · Electrical Eng. & Systems 2024-03-26 Xiajun Jiang , Sumeet Vadhavkar , Yubo Ye , Maryam Toloubidokhti , Ryan Missel , Linwei Wang

Standard objective functions used during the training of neural-network-based predictive models do not consider clinical criteria, leading to models that are not necessarily clinically acceptable. In this study, we look at this problem from…

Quantitative Methods · Quantitative Biology 2020-09-24 Maxime De Bois , Mounîm A. El Yacoubi , Mehdi Ammi

Digital twins are virtual replicas of physical entities and are poised to transform personalized medicine through the real-time simulation and prediction of human physiology. Translating this paradigm from engineering to biomedicine…

Blood glucose (BG) management is crucial for type-1 diabetes patients resulting in the necessity of reliable artificial pancreas or insulin infusion systems. In recent years, deep learning techniques have been utilized for a more accurate…

Machine Learning · Computer Science 2021-01-19 Md Fazle Rabby , Yazhou Tu , Md Imran Hossen , Insup Le , Anthony S Maida , Xiali Hei

Purpose: Digital twins are virtual interactive models of the real world, exhibiting identical behavior and properties. In surgical applications, computational analysis from digital twins can be used, for example, to enhance situational…

Gestational diabetes (GDM) poses a growing health risk to both pregnant women and their offspring. While telehealth interventions for GDM management have proven effective, they have traditionally relied on healthcare professionals for…

Human-Computer Interaction · Computer Science 2023-09-20 Mikko Kytö , Saila Koivusalo , Heli Tuomonen , Lisbeth Strömberg , Antti Ruonala , Pekka Marttinen , Seppo Heinonen , Giulio Jacucci

Cardiac arrest is one of the biggest global health problems, and early identification and management are key to enhancing the patient's prognosis. In this paper, we propose a novel framework that combines an EfficientNet-based deep learning…

Machine Learning · Computer Science 2025-09-10 Qasim Zia , Avais Jan , Zafar Iqbal , Muhammad Mumtaz Ali , Mukarram Ali , Murray Patterson

As we evolve towards more heterogeneous and cutting-edge mobile networks, Network Digital Twins (NDTs) are proving to be a promising paradigm in solving challenges faced by network operators, as they give a possibility of replicating the…

Emerging Technologies · Computer Science 2026-04-20 John Sengendo , Fabrizio Granelli

People living with Type 1 Diabetes (T1D) lose the ability to produce insulin naturally. To compensate, they inject synthetic insulin. One common way to inject insulin is through automated insulin delivery systems, which use sensors to…

Cryptography and Security · Computer Science 2024-01-04 Samuel T. King

To avoid serious diabetic complications, people with type 1 diabetes must keep their blood glucose levels (BGLs) as close to normal as possible. Insulin dosages and carbohydrate consumption are important considerations in managing BGLs.…

Machine Learning · Computer Science 2021-05-19 Jeremy Beauchamp , Razvan Bunescu , Cindy Marling , Zhongen Li , Chang Liu

Digital twins are virtual systems designed to predict how a real-world process will evolve in response to interventions. This modelling paradigm holds substantial promise in many applications, but rigorous procedures for assessing their…

Methodology · Statistics 2023-11-03 Rob Cornish , Muhammad Faaiz Taufiq , Arnaud Doucet , Chris Holmes

Diabetes Mellitus is a metabolic disorder which may result in severe and potentially fatal complications if not well-treated and monitored. In this study, a quantitative analysis of the data collected using CGM (Continuous Glucose…

Quantitative Methods · Quantitative Biology 2023-08-15 Giulia Elena Aliffi , Giovanni Nastasi , Vittorio Romano , Dario Pitocco , Alessandro Rizzi , Elvin J. Moore , Andrea De Gaetano

Diabetes is a chronic disease with a significant global health burden, requiring multi-stakeholder collaboration for optimal management. Large language models (LLMs) have shown promise in various healthcare scenarios, but their…

Computation and Language · Computer Science 2025-03-14 Lai Wei , Zhen Ying , Muyang He , Yutong Chen , Qian Yang , Yanzhe Hong , Jiaping Lu , Kaipeng Zheng , Shaoting Zhang , Xiaoying Li , Weiran Huang , Ying Chen