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Large Language Models (LLMs) have the potential to accelerate small molecule drug design due to their ability to reason about information from diverse sources and formats. However, their practical utility remains unclear due to the lack of…

Large language models (LLMs) are post-trained through reinforcement learning (RL) to evolve into Reasoning Language Models (RLMs), where the hallmark of this advanced reasoning is ``aha'' moments when they start to perform strategies, such…

Artificial Intelligence · Computer Science 2025-12-10 Sijia Chen , Baochun Li , Di Niu

Large Language Models (LLMs) have demonstrated tremendous potential as the next-generation ranking-based recommendation system. Many recent works have shown that LLMs can significantly outperform conventional click-through-rate (CTR)…

Information Retrieval · Computer Science 2025-03-18 Allen Lin , Renqin Cai , Yun He , Hanchao Yu , Jing Qian , Rui Li , Qifan Wang , James Caverlee

Recent advancements in the field of Natural Language Processing, particularly the development of large-scale language models that are pretrained on vast amounts of knowledge, are creating novel opportunities within the realm of Knowledge…

Computation and Language · Computer Science 2023-10-06 Anisa Rula , Jennifer D'Souza

Reinforcement learning (RL) finetuning has become a key technique for enhancing the reasoning abilities of large language models (LLMs). However, its effectiveness critically depends on the selection of training data. Recent advances…

Machine Learning · Computer Science 2026-03-12 Yixiu Mao , Yun Qu , Qi Wang , Heming Zou , Xiangyang Ji

Large Language Models (LLMs) have demonstrated remarkable success in various tasks such as natural language understanding, text summarization, and machine translation. However, their general-purpose nature often limits their effectiveness…

Computation and Language · Computer Science 2025-09-03 Zirui Song , Bin Yan , Yuhan Liu , Miao Fang , Mingzhe Li , Rui Yan , Xiuying Chen

Reinforcement learning (RL) has garnered increasing recognition for its potential to optimise dynamic treatment regimes (DTRs) in personalised medicine, particularly for drug dosage prescriptions and medication recommendations. However, a…

Machine Learning · Computer Science 2024-05-30 Zhiyao Luo , Mingcheng Zhu , Fenglin Liu , Jiali Li , Yangchen Pan , Jiandong Zhou , Tingting Zhu

The rapid growth of biomedical knowledge has outpaced our ability to efficiently extract insights and generate novel hypotheses. Large language models (LLMs) have emerged as a promising tool to revolutionize knowledge interaction and…

Computation and Language · Computer Science 2024-07-16 Biqing Qi , Kaiyan Zhang , Kai Tian , Haoxiang Li , Zhang-Ren Chen , Sihang Zeng , Ermo Hua , Hu Jinfang , Bowen Zhou

Large Language Models (LLM) exhibit zero-shot mathematical reasoning capacity as a behavior emergent with scale, commonly manifesting as chain-of-thoughts (CoT) reasoning. However, multiple empirical findings suggest that this prowess is…

Artificial Intelligence · Computer Science 2023-12-20 Subhabrata Dutta , Joykirat Singh , Ishan Pandey , Sunny Manchanda , Soumen Chakrabarti , Tanmoy Chakraborty

Social determinants of health (SDOH) play a critical role in Type 2 Diabetes (T2D) management but are often absent from electronic health records and risk prediction models. Most individual-level SDOH data is collected through structured…

Computation and Language · Computer Science 2026-01-21 Sasha Ronaghi , Prerit Choudhary , David H Rehkopf , Bryant Lin

The introduction of Large Language Models (LLMs) has advanced data representation and analysis, bringing significant progress in their use for medical questions and answering. Despite these advancements, integrating tabular data, especially…

Computation and Language · Computer Science 2024-09-23 Yanjun Gao , Skatje Myers , Shan Chen , Dmitriy Dligach , Timothy A Miller , Danielle Bitterman , Matthew Churpek , Majid Afshar

Large language models (LLMs) open up new horizons for sequential recommendations, owing to their remarkable language comprehension and generation capabilities. However, there are still numerous challenges that should be addressed to…

Information Retrieval · Computer Science 2024-03-29 Yuling Wang , Changxin Tian , Binbin Hu , Yanhua Yu , Ziqi Liu , Zhiqiang Zhang , Jun Zhou , Liang Pang , Xiao Wang

Recent developments in large language models (LLMs) have unlocked new opportunities for healthcare, from information synthesis to clinical decision support. These new LLMs are not just capable of modeling language, but can also act as…

Human-Computer Interaction · Computer Science 2023-09-21 Nikita Mehandru , Brenda Y. Miao , Eduardo Rodriguez Almaraz , Madhumita Sushil , Atul J. Butte , Ahmed Alaa

Large Language Models (LLMs) have revolutionized artificial intelligence, demonstrating remarkable computational power and linguistic capabilities. However, these models are inherently prone to various biases stemming from their training…

Computation and Language · Computer Science 2025-02-14 Riccardo Cantini , Giada Cosenza , Alessio Orsino , Domenico Talia

Clinical decision-making is a dynamic, interactive, and cyclic process where doctors have to repeatedly decide on which clinical action to perform and consider newly uncovered information for diagnosis and treatment. Large Language Models…

Computation and Language · Computer Science 2026-03-03 David Bani-Harouni , Chantal Pellegrini , Ege Özsoy , Nassir Navab , Matthias Keicher

Large language models (LLMs) have exhibited remarkable performance on complex reasoning tasks, with reinforcement learning under verifiable rewards (RLVR) emerging as a principled framework for aligning model behavior with reasoning chains.…

Artificial Intelligence · Computer Science 2026-05-05 Yunjian Zhang , Sudong Wang , Yang Li , Peiran Xu , Conghao Zhou , Xiaoyue Ma , Jianing Li , Yao Zhu

Recent advancements in large language models (LLMs) have shown promise in medical applications such as disease diagnosis and treatment planning. However, most existing medical LLMs struggle with the deep reasoning required for complex…

Computation and Language · Computer Science 2025-07-31 Hongzhou Yu , Tianhao Cheng , Yingwen Wang , Wen He , Qing Wang , Ying Cheng , Yuejie Zhang , Rui Feng , Xiaobo Zhang

Efficient and sustainable crop production process management is crucial to meet the growing global demand for food, fuel, and feed while minimizing environmental impacts. Traditional crop management practices, often developed through…

Systems and Control · Electrical Eng. & Systems 2024-10-15 Dong Chen , Yanbo Huang

Managing physiological variables within clinically safe target zones is a central challenge in healthcare, particularly for chronic conditions such as Type 1 Diabetes Mellitus (T1DM). Reinforcement learning (RL) offers promise for…

Machine Learning · Computer Science 2025-08-07 David H. Mguni , Jing Dong , Wanrong Yang , Ziquan Liu , Muhammad Salman Haleem , Baoxiang Wang

Large language models (LLMs) can capture rich representations of concepts that are useful for real-world tasks. However, language alone is limited. While existing LLMs excel at text-based inferences, health applications require that models…

Computation and Language · Computer Science 2023-05-26 Xin Liu , Daniel McDuff , Geza Kovacs , Isaac Galatzer-Levy , Jacob Sunshine , Jiening Zhan , Ming-Zher Poh , Shun Liao , Paolo Di Achille , Shwetak Patel