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Pharmaceutical process design and development for generic, innovative, or personalized drugs have always been a time-consuming, costly, rigorous process, that involves multi-stage evaluation for better quality control and assurance. Large…

Emerging Technologies · Computer Science 2025-03-24 Leqi Lin , Xingyu Zhou , Kaiyuan Yang , Xizhong Chen

The recommendation of medication is a vital aspect of intelligent healthcare systems, as it involves prescribing the most suitable drugs based on a patient's specific health needs. Unfortunately, many sophisticated models currently in use…

Information Retrieval · Computer Science 2025-01-28 Qidong Liu , Xian Wu , Xiangyu Zhao , Yuanshao Zhu , Zijian Zhang , Feng Tian , Yefeng Zheng

Large Language Models (LLMs) have shown remarkable capabilities in manipulating natural language across multiple applications, but their ability to handle simple reasoning tasks is often questioned. In this work, we aim to provide a…

Computation and Language · Computer Science 2025-05-05 Alessandro Raganato , Rafael Peñaloza , Marco Viviani , Gabriella Pasi

People have long hoped for a conversational system that can assist in real-life situations, and recent progress on large language models (LLMs) is bringing this idea closer to reality. While LLMs are often impressive in performance, their…

Computation and Language · Computer Science 2025-02-06 Linkai Peng , Baorian Nuchged , Yingming Gao

Large Language Models (LLMs) have rapidly transformed the landscape of artificial intelligence, enabling natural language interfaces and dynamic orchestration of software components. However, their reliance on probabilistic inference limits…

Machine Learning · Computer Science 2025-07-01 Claudionor Coelho , Yanen Li , Philip Tee

Large Language Models (LLMs) have been found to struggle with systematic reasoning. Even on tasks where they appear to perform well, their performance often depends on shortcuts, rather than on genuine reasoning abilities, leading them to…

Artificial Intelligence · Computer Science 2025-06-03 Irtaza Khalid , Amir Masoud Nourollah , Steven Schockaert

Large language models (LLMs) often require vast amounts of text to effectively acquire new knowledge. While continuing pre-training on large corpora or employing retrieval-augmented generation (RAG) has proven successful, updating an LLM…

Computation and Language · Computer Science 2025-08-11 Hugo Abonizio , Thales Almeida , Roberto Lotufo , Rodrigo Nogueira

Real-world adoption of closed-loop insulin delivery systems (CLIDS) in type 1 diabetes remains low, driven not by technical failure, but by diverse behavioral, psychosocial, and social barriers. We introduce ChatCLIDS, the first benchmark…

Artificial Intelligence · Computer Science 2026-04-14 Zonghai Yao , Talha Chafekar , Junda Wang , Shuo Han , Feiyun Ouyang , Junhui Qian , Lingxi Li , Hong Yu

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

Large Language Models (LLMs) have demonstrated potential in predicting mental health outcomes from online text, yet traditional classification methods often lack interpretability and robustness. This study evaluates structured reasoning…

Computation and Language · Computer Science 2026-01-09 Avinash Patil , Amardeep Kour Gedhu

Natural language processing (NLP) is a key technology to extract important patient information from clinical narratives to support healthcare applications. The rapid development of large language models (LLMs) has revolutionized many NLP…

Computation and Language · Computer Science 2025-09-08 Cheng Peng , Xinyu Dong , Mengxian Lyu , Daniel Paredes , Yaoyun Zhang , Yonghui Wu

Digital health interventions increasingly deliver home exercise programs via sensor-equipped devices such as smartphones, enabling remote monitoring of adherence and performance. However, current software is usually authored before clinical…

Deep reinforcement learning (DRL) shows promising potential for autonomous driving decision-making. However, DRL demands extensive computational resources to achieve a qualified policy in complex driving scenarios due to its low learning…

Robotics · Computer Science 2024-12-25 Hao Pang , Zhenpo Wang , Guoqiang Li

Large Language Models (LLMs) are increasingly used in intelligent systems that perform reasoning, summarization, and code generation. Their ability to follow natural-language instructions, while powerful, also makes them vulnerable to a new…

Cryptography and Security · Computer Science 2025-11-13 Daniyal Ganiuly , Assel Smaiyl

With the advancement of technology, large language models (LLMs) have achieved remarkable performance across various natural language processing (NLP) tasks, powering LLM-integrated applications like Microsoft Copilot. However, as LLMs…

Cryptography and Security · Computer Science 2025-08-05 Yulin Chen , Haoran Li , Zihao Zheng , Yangqiu Song , Dekai Wu , Bryan Hooi

Attention-based architectures trained on internet-scale language data have demonstrated state of the art reasoning ability for various language-based tasks, such as logic problems and textual reasoning. Additionally, these Large Language…

Robotics · Computer Science 2025-08-22 Mark Van der Merwe , Devesh Jha

Large language models (LLMs) are increasingly adopted in educational technologies for a variety of tasks, from generating instructional materials and assisting with assessment design to tutoring. While prior work has investigated how models…

Computation and Language · Computer Science 2025-12-24 Kirk Vanacore , Rene F. Kizilcec

Leader-follower interaction is an important paradigm in human-robot interaction (HRI). Yet, assigning roles in real time remains challenging for resource-constrained mobile and assistive robots. While large language models (LLMs) have shown…

Human-Computer Interaction · Computer Science 2026-03-13 Rafael R. Baptista , André de Lima Salgado , Ricardo V. Godoy , Marcelo Becker , Thiago Boaventura , Gustavo J. G. Lahr

Sequential Recommendation (SR) task involves predicting the next item a user is likely to interact with, given their past interactions. The SR models examine the sequence of a user's actions to discern more complex behavioral patterns and…

Information Retrieval · Computer Science 2025-04-22 Wujiang Xu , Qitian Wu , Zujie Liang , Jiaojiao Han , Xuying Ning , Yunxiao Shi , Wenfang Lin , Yongfeng Zhang

Instruction tuning -- supervised fine-tuning using instruction-response pairs -- is a key step in making pre-trained large language models (LLMs) instructable. Meanwhile, LLMs perform multitask learning during their pre-training, acquiring…

Computation and Language · Computer Science 2025-09-16 Seokhyun An , Minji Kim , Hyounghun Kim