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Adaptability has been regarded as a central feature in the foundation models, enabling them to effectively acclimate to unseen downstream tasks. Parameter-efficient fine-tuning methods such as celebrated LoRA facilitate efficient adaptation…

Machine Learning · Computer Science 2026-02-10 Gagik Magakyan , Amirhossein Reisizadeh , Chanwoo Park , Pablo A. Parrilo , Asuman Ozdaglar

The deep learning field is converging towards the use of general foundation models that can be easily adapted for diverse tasks. While this paradigm shift has become common practice within the field of natural language processing, progress…

Computer Vision and Pattern Recognition · Computer Science 2023-11-15 Joana Palés Huix , Adithya Raju Ganeshan , Johan Fredin Haslum , Magnus Söderberg , Christos Matsoukas , Kevin Smith

Low-rank adaptation (LoRA) has emerged as the de facto standard for parameter-efficient fine-tuning (PEFT) of foundation models, enabling the adaptation of billion-parameter networks with minimal computational and memory overhead. Despite…

Machine Learning · Computer Science 2026-04-24 Bingcong Li , Yilang Zhang , Georgios B. Giannakis

Pathology reports serve as the definitive record for breast cancer staging, yet their unstructured format impedes large-scale data curation. While Large Language Models (LLMs) offer semantic reasoning, their deployment is often limited by…

Machine Learning · Computer Science 2026-04-16 Jiahao Shao , Anam Nawaz Khan , Christopher Brett , Tom Berg , Xueping Li , Bing Yao

Foundation models (FMs) are transforming computational pathology by offering new ways to analyze histopathology images. However, FMs typically require weeks of training on large databases, making their creation a resource-intensive process.…

Image and Video Processing · Electrical Eng. & Systems 2026-01-27 Till Nicke , Daniela Schacherer , Jan Raphael Schäfer , Natalia Artysh , Antje Prasse , André Homeyer , Andrea Schenk , Henning Höfener , Johannes Lotz

Foundation Models have demonstrated significant success across various domains in Artificial Intelligence (AI), yet their capabilities for brainwave modeling remain unclear. In this paper, we comprehensively evaluate current Large Brainwave…

Machine Learning · Computer Science 2025-11-26 Na Lee , Konstantinos Barmpas , Yannis Panagakis , Dimitrios Adamos , Nikolaos Laskaris , Stefanos Zafeiriou

Deep learning has driven significant advances in mitotic figure analysis within computational pathology. In this paper, we present our approach to the Mitosis Domain Generalization (MIDOG) 2025 Challenge, which consists of two distinct…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Shuting Xu , Runtong Liu , Zhixuan Chen , Junlin Hou , Hao Chen

Atypical mitotic figures (AMFs) are clinically relevant indicators of abnormal cell division, yet their reliable detection remains challenging due to morphological ambiguity and scanner variability. In this work, we investigated three…

Image and Video Processing · Electrical Eng. & Systems 2025-09-08 Biwen Meng , Xi Long , Jingxin Liu

Low-Rank Adaptation (LoRA) is widely adopted for downstream fine-tuning of foundation models due to its efficiency and zero additional inference cost. Many real-world applications require foundation models to specialize in several specific…

Machine Learning · Computer Science 2025-09-30 Jian Liang , Wenke Huang , Xianda Guo , Guancheng Wan , Bo Du , Mang Ye

Mitotic figure detection is a crucial task in computational pathology, as mitotic activity serves as a strong prognostic marker for tumor aggressiveness. However, domain variability that arises from differences in scanners, tissue types,…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Yasemin Topuz , M. Taha Gökcan , Serdar Yıldız , Songül Varlı

Foundation models, large-scale, pre-trained deep-learning models adapted to a wide range of downstream tasks have gained significant interest lately in various deep-learning problems undergoing a paradigm shift with the rise of these…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Bobby Azad , Reza Azad , Sania Eskandari , Afshin Bozorgpour , Amirhossein Kazerouni , Islem Rekik , Dorit Merhof

This report details our submission to the Mitotic Domain Generalization (MIDOG) 2025 challenge, which addresses the critical task of mitotic figure detection in histopathology for cancer prognostication. Following the "Bitter…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Zhuoyan Shen , Esther Bär , Maria Hawkins , Konstantin Bräutigam , Charles-Antoine Collins-Fekete

Pathologist-defined labels are the gold standard for histopathological data sets, regardless of well-known limitations in consistency for some tasks. To date, some datasets on mitotic figures are available and were used for development of…

Computer Vision and Pattern Recognition · Computer Science 2020-10-22 Christof A. Bertram , Mitko Veta , Christian Marzahl , Nikolas Stathonikos , Andreas Maier , Robert Klopfleisch , Marc Aubreville

Assessing the Mitotic Count has a known high degree of intra- and inter-rater variability. Computer-aided systems have proven to decrease this variability and reduce labeling time. These systems, however, are generally highly dependent on…

Image and Video Processing · Electrical Eng. & Systems 2022-03-16 Frauke Wilm , Christian Marzahl , Katharina Breininger , Marc Aubreville

Mitotic activity is an important feature for grading several cancer types. Counting mitotic figures (MFs) is a time-consuming, laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incorrect grading and…

Deep metric learning aims to learn a function mapping image pixels to embedding feature vectors that model the similarity between images. Two major applications of metric learning are content-based image retrieval and face verification. For…

Computer Vision and Pattern Recognition · Computer Science 2019-08-06 Andrew Zhai , Hao-Yu Wu

Recent advancements in training paradigms for Large Language Models (LLMs) have unlocked their remarkable capabilities in natural language processing and cross-domain generalization. While LLMs excel in tasks like programming and…

Machine Learning · Computer Science 2025-10-01 Yuan Huang

Despite the significant potential of Foundation Models (FMs) in medical imaging, their application to prognosis prediction remains challenging due to data scarcity, class imbalance, and task complexity, which limit their clinical adoption.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-16 Filippo Ruffini , Elena Mulero Ayllon , Linlin Shen , Paolo Soda , Valerio Guarrasi

Foundation models pretrained on large-scale 3D medical imaging data face challenges when adapted to multiple downstream tasks under continual learning with limited labeled data. We address few-shot continual learning for 3D brain MRI by…

Image and Video Processing · Electrical Eng. & Systems 2026-03-02 Chi-Sheng Chen , Xinyu Zhang , Guan-Ying Chen , Qiuzhe Xie , Fan Zhang , En-Jui Kuo

Mitotic figure count is an important marker of tumor proliferation and has been shown to be associated with patients' prognosis. Deep learning based mitotic figure detection methods have been utilized to automatically locate the cell in…

Computer Vision and Pattern Recognition · Computer Science 2021-09-01 Jingtang Liang , Cheng Wang , Yujie Cheng , Zheng Wang , Fang Wang , Liyu Huang , Zhibin Yu , Yubo Wang