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Depression is one of the leading causes of disability worldwide, posing a severe burden on individuals, healthcare systems, and society at large. Recent advancements in Large Language Models (LLMs) have shown promise in addressing mental…

Computation and Language · Computer Science 2025-02-11 Shiyu Teng , Jiaqing Liu , Rahul Kumar Jain , Shurong Chai , Ruibo Hou , Tomoko Tateyama , Lanfen Lin , Yen-wei Chen

Mental health is a growing global concern, prompting interest in AI-driven solutions to expand access to psychosocial support. \emph{Peer support}, grounded in lived experience, offers a valuable complement to professional care. However,…

Human-Computer Interaction · Computer Science 2026-04-10 Kellie Yu Hui Sim , Roy Ka-Wei Lee , Kenny Tsu Wei Choo

With the advancement of large language models, many dialogue systems are now capable of providing reasonable and informative responses to patients' medical conditions. However, when patients consult their doctor, they may experience…

Computation and Language · Computer Science 2025-06-17 Shang-Chi Tsai , Yun-Nung Chen

Large language models (LLMs) hold great promise for assisting clinical interviews due to their fluent interactive capabilities and extensive medical knowledge. However, the lack of high-quality interview dialogue data and widely accepted…

Computation and Language · Computer Science 2025-04-15 Jing Chen , Zhihua Wei , Wei Zhang , Yingying Hu , Qiong Zhang

Difficult-to-treat depression (DTD) has been proposed as a broader and more clinically comprehensive perspective on a person's depressive disorder where despite treatment, they continue to experience significant burden. We sought to develop…

Computation and Language · Computer Science 2024-02-13 Isabelle Lorge , Dan W. Joyce , Niall Taylor , Alejo Nevado-Holgado , Andrea Cipriani , Andrey Kormilitzin

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical…

The application of the Multi-modal Large Language Models (MLLMs) in medical clinical scenarios remains underexplored. Previous benchmarks only focus on the capacity of the MLLMs in medical visual question-answering (VQA) or report…

Computation and Language · Computer Science 2024-08-19 Hongcheng Liu , Yusheng Liao , Siqv Ou , Yuhao Wang , Heyang Liu , Yanfeng Wang , Yu Wang

Traditional applications of natural language processing (NLP) in healthcare have predominantly focused on patient-centered services, enhancing patient interactions and care delivery, such as through medical dialogue systems. However, the…

Computation and Language · Computer Science 2024-06-11 Hengguan Huang , Songtao Wang , Hongfu Liu , Hao Wang , Ye Wang

While recently developed NLP explainability methods let us open the black box in various ways (Madsen et al., 2022), a missing ingredient in this endeavor is an interactive tool offering a conversational interface. Such a dialogue system…

Computation and Language · Computer Science 2023-10-24 Nils Feldhus , Qianli Wang , Tatiana Anikina , Sahil Chopra , Cennet Oguz , Sebastian Möller

With appropriate data selection and training techniques, Large Language Models (LLMs) have demonstrated exceptional success in various medical examinations and multiple-choice questions. However, the application of LLMs in medical dialogue…

Computation and Language · Computer Science 2024-03-12 Jiageng Wu , Xian Wu , Yefeng Zheng , Jie Yang

VR simulation in Health Professions (HP) education demonstrates huge potential, but fixed learning content with little customization limits its application beyond lab environments. To address these limitations in the context of VR for…

Human-Computer Interaction · Computer Science 2025-03-04 Xiuqi Tommy Zhu , Heidi Cheerman , Minxin Cheng , Sheri Kiami , Leanne Chukoskie , Eileen McGivney

Non-invasive methods for diagnosing mental health conditions, such as speech analysis, offer promising potential in modern medicine. Recent advancements in machine learning, particularly speech foundation models, have shown significant…

Audio and Speech Processing · Electrical Eng. & Systems 2024-10-01 Marc de Gennes , Adrien Lesage , Martin Denais , Xuan-Nga Cao , Simon Chang , Pierre Van Remoortere , Cyrille Dakhlia , Rachid Riad

Deploying clinical ML is slow and brittle: models that work at one hospital often degrade under distribution shifts at the next. In this work, we study a simple question -- can large language models (LLMs) create portable patient embeddings…

Machine Learning · Computer Science 2026-04-21 Zongliang Ji , Yifei Sun , Andre Amaral , Anna Goldenberg , Rahul G. Krishnan

Synthetic clinical data are increasingly important for advancing AI in healthcare, given strict privacy constraints on real-world EHRs, limited availability of annotated rare-condition data, and systemic biases in observational datasets.…

Machine Learning · Computer Science 2025-09-16 Rumeng Li , Xun Wang , Hong Yu

Synthetic data adoption in healthcare is driven by privacy concerns, data access limitations, and high annotation costs. We explore synthetic Prolonged Exposure (PE) therapy conversations for PTSD as a scalable alternative for training…

Computation and Language · Computer Science 2025-09-23 Suhas BN , Dominik Mattioli , Saeed Abdullah , Rosa I. Arriaga , Chris W. Wiese , Andrew M. Sherrill

The demand for psychological counselling has grown significantly in recent years, particularly with the global outbreak of COVID-19, which has heightened the need for timely and professional mental health support. Online psychological…

Computation and Language · Computer Science 2023-09-04 Tin Lai , Yukun Shi , Zicong Du , Jiajie Wu , Ken Fu , Yichao Dou , Ziqi Wang

Large language models (LLMs) show promise for supporting clinicians in diagnostic communication by generating explanations and guidance for patients. Yet their ability to produce outputs that are both understandable and empathetic remains…

Computation and Language · Computer Science 2025-11-04 Jianzhou Yao , Shunchang Liu , Guillaume Drui , Rikard Pettersson , Alessandro Blasimme , Sara Kijewski

Language Models (LMs) struggle with linguistic understanding at the discourse level, even though discourse patterns such as coherence, cohesion, and narrative flow are prevalent in their pre-training data. To improve the discourse…

Computation and Language · Computer Science 2026-02-17 Zachary Bamberger , Ofek Glick , Chaim Baskin , Yonatan Belinkov

The integration of Computer-Aided Diagnosis (CAD) with Large Language Models (LLMs) presents a promising frontier in clinical applications, notably in automating diagnostic processes akin to those performed by radiologists and providing…

Computer Vision and Pattern Recognition · Computer Science 2024-05-22 Zihao Zhao , Sheng Wang , Jinchen Gu , Yitao Zhu , Lanzhuju Mei , Zixu Zhuang , Zhiming Cui , Qian Wang , Dinggang Shen

We introduce SoftTiger, a clinical large language model (CLaM) designed as a foundation model for healthcare workflows. The narrative and unstructured nature of clinical notes is a major obstacle for healthcare intelligentization. We…

Computation and Language · Computer Science 2024-08-21 Ye Chen , Igor Couto , Wei Cai , Cong Fu , Bruno Dorneles
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