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Mental health disorders are rising worldwide. However, the availability of trained clinicians has not scaled proportionally, leaving many people without adequate or timely support. To bridge this gap, recent studies have shown the promise…

Computation and Language · Computer Science 2025-08-19 Aishik Mandal , Prottay Kumar Adhikary , Hiba Arnaout , Iryna Gurevych , Tanmoy Chakraborty

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

Large language models (LLMs) are emerging as promising tools for mental health care, offering scalable support through their ability to generate human-like responses. However, the effectiveness of these models in clinical settings remains…

Artificial Intelligence · Computer Science 2024-08-22 Yining Hua , Hongbin Na , Zehan Li , Fenglin Liu , Xiao Fang , David Clifton , John Torous

In this experiment, a model was devised, trained, and evaluated to automate psychotherapist/client text conversations through the use of state-of-the-art, Seq2Seq Transformer-based Natural Language Generation (NLG) systems. Through training…

Computation and Language · Computer Science 2021-04-22 Houjun Liu

Mental health disorders are one of the most serious diseases in the world. Most people with such a disease lack access to adequate care, which highlights the importance of training models for the diagnosis and treatment of mental health…

Computation and Language · Computer Science 2025-02-06 Cheng Li , May Fung , Qingyun Wang , Chi Han , Manling Li , Jindong Wang , Heng Ji

Automatic depression detection from conversational interactions holds significant promise for scalable screening but remains hindered by severe data scarcity and a lack of clinical interpretability. Existing approaches typically rely on…

Computation and Language · Computer Science 2026-04-28 Rishitej Reddy Vyalla , Kritarth Prasad , Avinash Anand , Erik Cambria , Shaoxiong Ji , Faten S. Alamri , Zhengkui Wang

This paper investigates the capacity of small language models (0.5B-5B parameters) to generate empathetic responses for individuals with PTSD. We introduce Trauma-Informed Dialogue for Empathy (TIDE), a novel dataset comprising 10,000…

Computation and Language · Computer Science 2025-09-23 Suhas BN , Yash Mahajan , Dominik Mattioli , Andrew M. Sherrill , Rosa I. Arriaga , Chris W. Wiese , Saeed Abdullah

The development of large language models (LLMs) has brought unprecedented possibilities for artificial intelligence (AI) based medical diagnosis. However, the application perspective of LLMs in real diagnostic scenarios is still unclear…

Computation and Language · Computer Science 2024-05-21 Zhoujian Sun , Cheng Luo , Ziyi Liu , Zhengxing Huang

Large Language Model (LLM)-based systems increasingly rely on function calling to enable structured and controllable interaction with external data sources, yet existing datasets do not address mental health-oriented access to wearable…

Artificial Intelligence · Computer Science 2026-01-13 Fozle Rabbi Shafi , M. Anwar Hossain , Salimur Choudhury

Large language models (LLMs) are increasingly envisioned as decision-support tools in clinical practice, yet safe clinical reasoning demands integrating heterogeneous knowledge bases -- trials, primary studies, regulatory documents, and…

Computation and Language · Computer Science 2025-05-22 Shan Chen , Pedro Moreira , Yuxin Xiao , Sam Schmidgall , Jeremy Warner , Hugo Aerts , Thomas Hartvigsen , Jack Gallifant , Danielle S. Bitterman

Recent advances in LLMs have greatly improved general-domain NLP tasks. Yet, their adoption in critical domains, such as clinical trial recruitment, remains limited. As trials are designed in natural language and patient data is represented…

Computation and Language · Computer Science 2026-01-01 Shrestha Ghosh , Moritz Schneider , Carina Reinicke , Carsten Eickhoff

Health sensing for chronic disease management creates immense benefits for social welfare. Existing health sensing studies primarily focus on the prediction of physical chronic diseases. Depression, a widespread complication of chronic…

Artificial Intelligence · Computer Science 2025-04-17 Jiaheng Xie , Xiaohang Zhao , Xiang Liu , Xiao Fang

Psychiatric comorbidity is clinically significant yet challenging due to the complexity of multiple co-occurring disorders. To address this, we develop a novel approach integrating synthetic patient electronic medical record (EMR)…

Artificial Intelligence · Computer Science 2026-02-24 Tianxi Wan , Jiaming Luo , Siyuan Chen , Kunyao Lan , Jianhua Chen , Haiyang Geng , Mengyue Wu

Depression is one of the most prevalent mental health disorders globally. In recent years, multi-modal data, such as speech, video, and transcripts, has been increasingly used to develop AI-assisted depression assessment systems. Large…

Dementia is under-recognized in the community, under-diagnosed by healthcare professionals, and under-coded in claims data. Information on cognitive dysfunction, however, is often found in unstructured clinician notes within medical records…

Despite substantial progress in healthcare applications driven by large language models (LLMs), growing concerns around data privacy, and limited resources; the small language models (SLMs) offer a scalable and clinically viable solution…

Computation and Language · Computer Science 2025-04-28 Muskan Garg , Shaina Raza , Shebuti Rayana , Xingyi Liu , Sunghwan Sohn

Large language models (LLMs) offer emerging opportunities for psychological and behavioral research, but methodological guidance is lacking. This article provides a framework for using LLMs as psychological simulators across two primary…

Computers and Society · Computer Science 2026-04-07 Zhicheng Lin

Mental health remains a major public health concern, while access to timely psychological support is often limited. AI-based dialogue systems have emerged as promising tools to address these barriers, and recent advances in large language…

Computers and Society · Computer Science 2026-03-16 Daeun Lee , Dongje Yoo , Migyeong Yang , Jihyun An , Christine B. Cha , Jinyoung Han

The lack of explainability using relevant clinical knowledge hinders the adoption of Artificial Intelligence-powered analysis of unstructured clinical dialogue. A wealth of relevant, untapped Mental Health (MH) data is available in online…

Artificial Intelligence · Computer Science 2024-10-21 Sumit Dalal , Deepa Tilwani , Kaushik Roy , Manas Gaur , Sarika Jain , Valerie Shalin , Amit Sheth

The rapid evolution of Large Language Models (LLMs) is transforming AI, opening new opportunities in sensitive and high-impact areas such as Mental Health (MH). Yet, despite these advancements, recent evidence reveals that smaller-scale…

Computation and Language · Computer Science 2025-10-21 Federico Ravenda , Seyed Ali Bahrainian , Andrea Raballo , Antonietta Mira