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Drawing meaningful conclusions from inherently multimodal clinical data (including medical imaging) requires coordinating expertise across the clinical specialty, radiology, programming, and biostatistics. This fragmented process…

Multiagent Systems · Computer Science 2026-04-15 Lucas Stoffl , Benedikt Wiestler , Johannes C. Paetzold

In vitro cellular experimentation with genetic interventions, using for example CRISPR technologies, is an essential step in early-stage drug discovery and target validation that serves to assess initial hypotheses about causal associations…

Machine Learning · Computer Science 2021-10-25 Arash Mehrjou , Ashkan Soleymani , Andrew Jesson , Pascal Notin , Yarin Gal , Stefan Bauer , Patrick Schwab

Scientific discovery relies on scientists generating novel hypotheses that undergo rigorous experimental validation. To augment this process, we introduce an AI co-scientist, a multi-agent system built on Gemini 2.0. The AI co-scientist is…

Modern scientific discovery is bottlenecked not by data scarcity, but by the inability to synthesize fragmented knowledge into actionable hypotheses. This challenge is especially acute in battery materials research, where electrochemical…

Computation and Language · Computer Science 2026-05-26 Jaeha Oh , Byungchan Kim , Ju Li , Yang Jeong Park , Jin-Sung Park

Hypothesis generation in biomedical research has traditionally centered on uncovering hidden relationships within vast scientific literature, often using methods like Literature-Based Discovery (LBD). Despite progress, current approaches…

Computation and Language · Computer Science 2025-11-13 Fuyi Yang , Chenchen Ye , Mingyu Derek Ma , Yijia Xiao , Matthew Yang , Wei Wang

The exponential growth of scientific knowledge has made the automated generation of scientific hypotheses that combine novelty, feasibility, and research value a core challenge. Existing methods based on large language models fail to…

Artificial Intelligence · Computer Science 2025-08-05 Shiyang Duan , Yuan Tian , Qi Bing , Xiaowei Shao

While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis. Existing methods typically rely on static, linear mappings…

Computation and Language · Computer Science 2026-05-28 Zhuohan Ge , Haoyang Li , Yubo Wang , Nicole Hu , Chen Jason Zhang , Qing Li

The automation of scientific discovery represents a critical milestone in Artificial Intelligence (AI) research. However, existing agentic systems for science suffer from two fundamental limitations: rigid, pre-programmed workflows that…

Artificial Intelligence · Computer Science 2025-10-20 Ed Li , Junyu Ren , Xintian Pan , Cat Yan , Chuanhao Li , Dirk Bergemann , Zhuoran Yang

Speech synthesis is crucial for human-computer interaction, enabling natural and intuitive communication. However, existing datasets involve high construction costs due to manual annotation and suffer from limited character diversity,…

Computation and Language · Computer Science 2025-04-22 Xiang Li , Duyi Pan , Hongru Xiao , Jiale Han , Jing Tang , Jiabao Ma , Wei Wang , Bo Cheng

We present M-Reason, a demonstration system for transparent, agent-based reasoning and evidence integration in the biomedical domain, with a focus on cancer research. M-Reason leverages recent advances in large language models (LLMs) and…

Artificial Intelligence · Computer Science 2025-10-08 Oskar Wysocki , Magdalena Wysocka , Mauricio Jacobo , Harriet Unsworth , André Freitas

Repurposing approved drugs offers a time-efficient and cost-effective alternative to traditional drug development. However, in silico prediction of repurposing candidates is challenging and requires the effective collaboration of…

Artificial Intelligence · Computer Science 2026-02-10 Simon Süwer , Kester Bagemihl , Sylvie Baier , Lucia Dicunta , Markus List , Jan Baumbach , Andreas Maier , Fernando M. Delgado-Chaves

Healthcare professionals need effective ways to use, understand, and validate AI-driven clinical decision support systems. Existing systems face two key limitations: complex visualizations and a lack of grounding in scientific evidence. We…

Human-Computer Interaction · Computer Science 2025-07-08 Reza Samimi , Aditya Bhattacharya , Lucija Gosak , Gregor Stiglic , Katrien Verbert

Scientific progress increasingly relies on effective collaboration among researchers, a dynamic that large language models (LLMs) have only begun to emulate. While recent LLM-based scientist agents show promise in autonomous scientific…

Artificial Intelligence · Computer Science 2025-08-04 Weilun Yu , Shixiang Tang , Yonggui Huang , Nanqing Dong , Li Fan , Honggang Qi , Wei Liu , Xiaoli Diao , Xi Chen , Wanli Ouyang

Biomedical research results are being published at a high rate, and with existing search engines, the vast amount of published work is usually easily accessible. However, reproducing published results, either experimental data or…

Molecular Networks · Quantitative Biology 2017-06-19 Kai-Wen Liang , Qinsi Wang , Cheryl Telmer , Divyaa Ravichandran , Peter Spirtes , Natasa Miskov-Zivanov

The rapid spread of misinformation in the digital era poses significant challenges to public discourse, necessitating robust and scalable fact-checking solutions. Traditional human-led fact-checking methods, while credible, struggle with…

Artificial Intelligence · Computer Science 2025-06-24 Tam Trinh , Manh Nguyen , Truong-Son Hy

Large language models perform well on static medical examinations, yet clinical diagnosis often requires iterative evidence gathering under uncertainty. Building on prior interactive evaluation efforts, we introduce an OSCE-inspired…

Artificial Intelligence · Computer Science 2026-05-22 Chen Zhan , Xihe Qiu , Xiaoyu Tan , Xibing Zhuang , Gengchen Ma , Yue Zhang , Shuo Li , Peifeng Liu , Xiaoxiao Ge , Liang Liu , Lu Gan

Answering complex medical questions requires not only domain expertise and patient-specific information, but also structured and multi-perspective reasoning. Existing multi-agent approaches often rely on fixed roles or shallow interaction…

Artificial Intelligence · Computer Science 2026-03-04 Siqi Ma , Jiajie Huang , Fan Zhang , Yue Shen , Jinlin Wu , Guohui Fan , Zhu Zhang , Zelin Zang

Multi-agent large language model frameworks are promising for complex multi step reasoning, yet existing systems remain weak for scientific and knowledge intensive domains due to static prompts and agent roles, rigid workflows, and…

Artificial Intelligence · Computer Science 2026-03-04 Yichao Feng , Haoran Luo , Zhenghong Lin , Yiqun Sun , Pengfei Wei , Lawrence B. Hsieh , Anh Tuan Luu

Clinical diagnosis is a complex reasoning process in which clinicians gather evidence, form hypotheses, and test them against alternative explanations. In medical training, this reasoning is explicitly developed through counterfactual…

Computation and Language · Computer Science 2026-04-24 Zhiwen You , Xi Chen , Aniket Vashishtha , Simo Du , Gabriel Erion-Barner , Hongyuan Mei , Hao Peng , Yue Guo

Large language models (LLMs), have shown strong potential in scientific discovery, yet existing methods still face substantial challenges in the design of research workflows and multi-role collaboration mechanisms. To mitigate these issues,…

Artificial Intelligence · Computer Science 2026-05-26 Xiaoyu Xiong , Yuqi Ren , Deyi Xiong
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