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With recent breakthroughs in large language models (LLMs) for reasoning, planning, and complex task generation, artificial intelligence systems are transitioning from isolated single-agent architectures to multi-agent systems with…

Artificial Intelligence · Computer Science 2026-02-17 Linlin Wang , Tianqing Zhu , Laiqiao Qin , Longxiang Gao , Wanlei Zhou

Precision oncology aims to prescribe the optimal cancer treatment to the right patients, maximizing therapeutic benefits. However, identifying patient subgroups that may benefit more from experimental cancer treatments based on randomized…

Methodology · Statistics 2026-01-06 Xingyu Li , Qing Liu , Tony Jiang , Hong Amy Xia , Peng Wei , Brian P. Hobbs

Physical activity is crucial for human health. With the increasing availability of large-scale mobile health data, strong associations have been found between physical activity and various diseases. However, accurately capturing this…

Methodology · Statistics 2026-01-19 Xiaojing Sun , Bingxin Zhao , Fei Xue

Hematopoiesis is the process of blood cell formation, through which progenitor stem cells differentiate into mature forms, such as white and red blood cells or mature platelets. While the precursors of the mature forms share many regulatory…

Current epidemics in the biological and social domains are challenging the standard assumptions of mathematical contagion models. Chief among them are the complex patterns of transmission caused by heterogeneous group sizes and infection…

Physics and Society · Physics 2024-01-03 Guillaume St-Onge , Laurent Hébert-Dufresne , Antoine Allard

The construction of coherent prediction models holds great importance in medical research as such models enable health researchers to gain deeper insights into disease epidemiology and clinicians to identify patients at higher risk of…

Applications · Statistics 2024-01-17 Guanbo Wang , Sylvie Perreault , Robert W. Platt , Rui Wang , Marc Dorais , Mireille E. Schnitzer

Click-through rate (CTR) prediction, which models behavior sequence and non-sequential features (e.g., user/item profiles or cross features) to infer user interest, underpins industrial recommender systems. However, most methods face three…

Information Retrieval · Computer Science 2025-10-24 Shuwei Chen , Jiajun Cui , Zhengqi Xu , Fan Zhang , Jiangke Fan , Teng Zhang , Xingxing Wang

Recent work has developed Bayesian methods for the automatic statistical analysis and description of single time series as well as of homogeneous sets of time series data. We extend prior work to create an interpretable kernel embedding for…

Machine Learning · Computer Science 2019-08-27 Andre T. Nguyen , Edward Raff

How to estimate heterogeneity, e.g. the effect of some variable differing across observations, is a key question in political science. Methods for doing so make simplifying assumptions about the underlying nature of the heterogeneity to…

Methodology · Statistics 2021-03-31 Max Goplerud

Background: Understanding the relationship between the Omics and the phenotype is a central problem in precision medicine. The high dimensionality of metabolomics data challenges learning algorithms in terms of scalability and…

This paper provides a new methodology to analyze unobserved heterogeneity when observed characteristics are modeled nonlinearly. The proposed model builds on varying random coefficients (VRC) that are determined by nonlinear functions of…

Econometrics · Economics 2020-08-05 Christoph Breunig

Machine learning interpretation (MLI) has primarily been leveraged to foster clinician trust and extract insights from electronic health records (EHRs), rather than to guide subgroup-specific, operationalizable modeling strategies. To…

Machine Learning · Computer Science 2025-08-08 Ling Liao , Eva Aagaard

We augment linear Support Vector Machine (SVM) classifiers by adding three important features: (i) we introduce a regularization constraint to induce a sparse classifier; (ii) we devise a method that partitions the positive class into…

Applications · Statistics 2019-03-22 Taiyao Wang , Ioannis Ch. Paschalidis

Radiogenomics is an emerging field in cancer research that combines medical imaging data with genomic data to predict patients clinical outcomes. In this paper, we propose a multivariate sparse group lasso joint model to integrate imaging…

Methodology · Statistics 2022-06-06 Tiantian Zeng , Md Selim , Jie Zhang , Arnold Stromberg , Jin Chen , Chi Wang

Human mesh recovery (HMR) from a single RGB image is inherently ambiguous, as multiple 3D poses can correspond to the same 2D observation. Recent diffusion-based methods tackle this by generating various hypotheses, but often sacrifice…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Wenhao Shen , Hao Wang , Wanqi Yin , Fayao Liu , Xulei Yang , Chao Liang , Zhongang Cai , Guosheng Lin

Predicting patient mortality is an important and challenging problem in the healthcare domain, especially for intensive care unit (ICU) patients. Electronic health notes serve as a rich source for learning patient representations, that can…

Computation and Language · Computer Science 2019-10-16 Shaika Chowdhury , Chenwei Zhang , Philip S. Yu , Yuan Luo

Rapid, reliable, and accurate interpretation of medical time-series signals is crucial for high-stakes clinical decision-making. Deep learning methods offered unprecedented performance in medical signal processing but at a cost: they were…

Signal Processing · Electrical Eng. & Systems 2024-10-08 Sully F. Chen , Zhicheng Guo , Cheng Ding , Xiao Hu , Cynthia Rudin

In multicenter biomedical research, integrating data from multiple decentralized sites provides more robust and generalizable findings due to its larger sample size and the ability to account for the between-site heterogeneity. However,…

Methodology · Statistics 2025-12-29 Xiaokang Liu , Yuchen Yang , Yifei Sun , Jiang Bian , Yanyuan Ma , Raymond J. Carroll , Yong Chen

In medical, social, and behavioral research we often encounter datasets with a multilevel structure and multiple correlated dependent variables. These data are frequently collected from a study population that distinguishes several…

Methodology · Statistics 2023-12-18 Xynthia Kavelaars , Joris Mulder , Maurits Kaptein

Massive amounts of data are the foundation of data-driven recommendation models. As an inherent nature of big data, data heterogeneity widely exists in real-world recommendation systems. It reflects the differences in the properties among…

Information Retrieval · Computer Science 2023-05-26 Zimu Wang , Jiashuo Liu , Hao Zou , Xingxuan Zhang , Yue He , Dongxu Liang , Peng Cui