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Accurately predicting hospital readmission risks using electronic health records (EHRs) is critical for effective patient management and healthcare resource allocation. Patient populations in health systems are highly heterogeneous across…

A key challenge in building effective regression models for large and diverse populations is accounting for patient heterogeneity. An example of such heterogeneity is in health system risk modeling efforts where different combinations of…

Methodology · Statistics 2022-12-26 Jared D. Huling , Menggang Yu

Hospital readmissions have become one of the key measures of healthcare quality. Preventable readmissions have been identified as one of the primary targets for reducing costs and improving healthcare delivery. However, most data driven…

Machine Learning · Computer Science 2018-04-05 Jialiang Jiang , Sharon Hewner , Varun Chandola

Heterogeneity is a hallmark of complex diseases. Regression-based heterogeneity analysis, which is directly concerned with outcome-feature relationships, has led to a deeper understanding of disease biology. Such an analysis identifies the…

Methodology · Statistics 2022-11-29 Ziye Luo , Xinyue Yao , Yifan Sun , Xinyan Fan

This paper addresses patient heterogeneity associated with prediction problems in biomedical applications. We propose a systematic hypothesis testing approach to determine the existence of patient subgroup structure and the number of…

Methodology · Statistics 2021-01-08 Xu Gao , Weining Shen , Jing Ning , Ziding Feng , Jianhua Hu

The intensive care unit (ICU) comprises a complex hospital environment, where decisions made by clinicians have a high level of risk for the patients' lives. A comprehensive care pathway must then be followed to reduce p complications.…

Collaborative learning, which enables collaborative and decentralized training of deep neural networks at multiple institutions in a privacy-preserving manner, is rapidly emerging as a valuable technique in healthcare applications. However,…

Computer Vision and Pattern Recognition · Computer Science 2022-04-15 Liangqiong Qu , Niranjan Balachandar , Miao Zhang , Daniel Rubin

In many complex applications, data heterogeneity and homogeneity exist simultaneously. Ignoring either one will result in incorrect statistical inference. In addition, coping with complex data that are non-Euclidean becomes more common. To…

Methodology · Statistics 2021-05-28 Zixuan Han , Tao Li , Jinhong You

Problem definition: Mining for heterogeneous responses to an intervention is a crucial step for data-driven operations, for instance to personalize treatment or pricing. We investigate how to estimate price sensitivity from…

Methodology · Statistics 2025-01-08 Jean Pauphilet

Hospital readmissions remain a challenge for healthcare systems, especially among patients with chronic conditions such as diabetes. Unplanned readmissions within 30 days are costly, strain hospital resources, and can indicate poor care…

Human-Computer Interaction · Computer Science 2026-03-24 Martin Sanchez , Nick Tran , Vuthea Chheang

Heart rate prediction is vital for personalized health monitoring and fitness, while it frequently faces a critical challenge in real-world deployment: data heterogeneity. We classify it in two key dimensions: source heterogeneity from…

Machine Learning · Computer Science 2026-02-25 Zhengdong Huang , Zicheng Xie , Wentao Tian , Jingyu Liu , Lunhong Dong , Peng Yang

Revealing relationships between genes and disease phenotypes is a critical problem in biomedical studies. This problem has been challenged by the heterogeneity of diseases. Patients of a perceived same disease may form multiple subgroups,…

Methodology · Statistics 2022-11-30 Yifan Sun , Ziye Luo , Xinyan Fan

Understanding causal heterogeneity is essential for scientific discovery in domains such as biology and medicine. However, existing methods lack causal awareness, with insufficient modeling of heterogeneity, confounding, and observational…

Machine Learning · Computer Science 2025-10-29 Wenrui Li , Qinghao Zhang , Xiaowo Wang

In many applications, data can be heterogeneous in the sense of spanning latent groups with different underlying distributions. When predictive models are applied to such data the heterogeneity can affect both predictive performance and…

Machine Learning · Statistics 2022-05-04 Thomas Lartigue , Sach Mukherjee

Identification of patients at high risk for readmission could help reduce morbidity and mortality as well as healthcare costs. Most of the existing studies on readmission prediction did not compare the contribution of data categories. In…

Quantitative Methods · Quantitative Biology 2018-03-23 Wendong Ge , Hee Yeun Kim , Sonali Desai , Leonid Perlovsky , Alexander Turchin

In this work, we study the problem pertaining to personalized classification of subclinical atherosclerosis by developing a hierarchical graph neural network framework to leverage two characteristic modalities of a patient: clinical…

Machine Learning · Computer Science 2025-09-15 Irsyad Adam , Steven Swee , Erika Yilin , Ethan Ji , William Speier , Dean Wang , Alex Bui , Wei Wang , Karol Watson , Peipei Ping

Heterogeneous data are now ubiquitous in many applications in which correctly identifying the subgroups from a heterogeneous population is critical. Although there is an increasing body of literature on subgroup detection, existing methods…

Methodology · Statistics 2025-12-09 Jie Wu , Bo Zhang , Daoji Li , Zemin Zheng

Reducing preventable hospital readmissions is a national priority for payers, providers, and policymakers seeking to improve health care and lower costs. The rate of readmission is being used as a benchmark to determine the quality of…

Machine Learning · Computer Science 2025-10-31 Avinash Kadimisetty , Arun Rajagopalan , Vijendra SK

Both biological and artificial neural networks inherently balance their performance with their operational cost, which balances their computational abilities. Typically, an efficient neuromorphic neural network is one that learns…

Neurons and Cognition · Quantitative Biology 2023-12-25 Hugo J. Ladret , Christian Casanova , Laurent Udo Perrinet

Machine learning approaches have been effective in predicting adverse outcomes in different clinical settings. These models are often developed and evaluated on datasets with heterogeneous patient populations. However, good predictive…

Machine Learning · Computer Science 2018-06-11 Harini Suresh , Jen J. Gong , John Guttag
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