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In clinical decision-making, predictive models face a persistent trade-off: accurate models are often opaque "black boxes," while interpretable methods frequently lack predictive precision or statistical grounding. In this paper, we…

Artificial Intelligence · Computer Science 2026-02-10 Zijian Shao , Haiyang Shen , Mugeng Liu , Gecheng Fu , Yaoqi Guo , Yanfeng Wang , Yun Ma

Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing…

Neurons and Cognition · Quantitative Biology 2026-04-01 Siyuan Du , Siyi Li , Shuwei Bai , Ang Li , Haolin Li , Mingqing Xiao , Yang Pan , Dongsheng Li , Weidi Xie , Yanfeng Wang , Ya Zhang , Chencheng Zhang , Jiangchao Yao

Parkinsons disease (PD) alters cortical neural dynamics, yet reliable non-invasive electrophysiological biomarkers remain elusive. This study examined whether interpretable EEG features capturing complementary aspects of neural dynamics can…

Neurons and Cognition · Quantitative Biology 2026-04-14 Antonios G. Dougalis

This paper enhances dysarthric and dysphonic speech recognition by fine-tuning pretrained automatic speech recognition (ASR) models on the 2023-10-05 data package of the Speech Accessibility Project (SAP), which contains the speech of 253…

Audio and Speech Processing · Electrical Eng. & Systems 2024-10-01 Xiuwen Zheng , Bornali Phukon , Mark Hasegawa-Johnson

Accurate diagnosis of Parkinson disease, especially in its early stages, can be a challenging task. The application of machine learning techniques helps improve the diagnostic accuracy of Parkinson disease detection but only few studies…

Machine Learning · Computer Science 2024-12-25 Majid Ali , Hina Shakir , Asia Samreen , Sohaib Ahmed

In this paper, an explainable deep learning-based classifier based on adaptive sinc filters for Parkinson's Disease diagnosis (PD) along with determining its severity, based on analyzing the gait cycle (SincPD) is presented. Considering the…

Signal Processing · Electrical Eng. & Systems 2025-02-26 Armin Salimi-Badr , Mahan Veisi , Sadra Berangi

Detecting Parkinson's Disease in its early stages using EEG data presents a significant challenge. This paper introduces a novel approach, representing EEG data as a 15-variate series of bandpower and peak frequency values/coefficients. The…

Neurons and Cognition · Quantitative Biology 2023-12-11 Amarpal Sahota , Amber Roguski , Matthew W. Jones , Michal Rolinski , Alan Whone , Raul Santos-Rodriguez , Zahraa S. Abdallah

Parkinson's disease (PD), a prevalent neurodegenerative disorder, significantly affects patients' daily functioning and social interactions. To facilitate a more efficient and accessible diagnostic approach for PD, we propose a dynamic…

Computer Vision and Pattern Recognition · Computer Science 2025-12-11 Xiaochen Huang , Xiaochen Bi , Cuihua Lv , Xin Wang , Haoyan Zhang , Wenjing Jiang , Xin Ma , Yibin Li

Parkinson's disease is a neurodegenerative disorder that can be very tricky to diagnose and treat. Such early symptoms can include tremors, wheezy breathing, and changes in voice quality as critical indicators of neural damage. Notably,…

Sound · Computer Science 2025-11-20 Abishek Karthik , Pandiyaraju V , Dominic Savio M , Rohit Swaminathan S

This paper presents a method for detecting mispronunciations with the aim of improving Computer Assisted Language Learning (CALL) tools used by foreign language learners. The algorithm is based on Principle Component Analysis (PCA). It is…

Sound · Computer Science 2016-02-29 Zhenhao Ge , Sudhendu R. Sharma , Mark J. T. Smith

Parkinsons disease, the fastest growing neurodegenerative disorder globally, has seen a 50 percent increase in cases within just two years. As speech, memory, and motor symptoms worsen over time, early diagnosis is crucial for preserving…

Quantitative Methods · Quantitative Biology 2024-12-02 Diya Vatsavai , Anya Iyer , Ashwin A. Nair

Chronic obstructive pulmonary disease (COPD) causes lung inflammation and airflow blockage leading to a variety of respiratory symptoms; it is also a leading cause of death and affects millions of individuals around the world. Patients…

Speech is a rich biomarker that encodes substantial information about the health of a speaker, and thus it has been proposed for the detection of numerous diseases, achieving promising results. However, questions remain about what the…

Audio and Speech Processing · Electrical Eng. & Systems 2024-09-17 Catarina Botelho , Alberto Abad , Tanja Schultz , Isabel Trancoso

Parkinson's disease (PD) is a progressive neurological disorder that impairs movement control, leading to symptoms such as tremors, stiffness, and bradykinesia. Many researchers analyzing handwriting data for PD detection typically rely on…

Signal Processing · Electrical Eng. & Systems 2024-12-25 Jungpil Shin , Abu Saleh Musa Miah , Koki Hirooka , Md. Al Mehedi Hasan , Md. Maniruzzaman

Parkinson's disease (PD) is the most widespread movement condition and the second most common neurodegenerative disorder, following Alzheimer's. Movement symptoms and imaging techniques are the most popular ways to diagnose this disease.…

Sound · Computer Science 2024-10-28 Paria Ghaheri , Ahmadreza Shateri , Hamid Nasiri

Parkinson's Disease (PD) medication management presents unique challenges due to heterogeneous disease progression and treatment response. Neurologists must balance symptom control with optimal dopaminergic dosing based on functional…

Machine Learning · Computer Science 2025-08-15 Ricardo Diaz-Rincon , Muxuan Liang , Adolfo Ramirez-Zamora , Benjamin Shickel

Parkinson's disease (PD) is a progressive neurological disorder primarily affecting motor function resulting in tremor at rest, rigidity, bradykinesia, and postural instability. The physical severity of PD impairments can be quantified…

Computer Vision and Pattern Recognition · Computer Science 2020-07-20 Mandy Lu , Kathleen Poston , Adolf Pfefferbaum , Edith V. Sullivan , Li Fei-Fei , Kilian M. Pohl , Juan Carlos Niebles , Ehsan Adeli

Parkinson's disease (PD) is a progressive neurodegenerative disorder that results in a variety of motor dysfunction symptoms, including tremors, bradykinesia, rigidity and postural instability. The diagnosis of PD mainly relies on clinical…

Computer Vision and Pattern Recognition · Computer Science 2022-07-15 Haozheng Zhang , Edmond S. L. Ho , Xiatian Zhang , Hubert P. H. Shum

Labeled speech data from patients with Parkinsons disease (PD) are scarce, and the statistical distributions of training and test data differ significantly in the existing datasets. To solve these problems, dimensional reduction and sample…

Machine Learning · Computer Science 2020-02-11 Xiaoheng Zhang , Yongming Li , Pin Wang , Xiaoheng Tan , Yuchuan Liu

In recent years, deep learning methods have achieved great success in various fields due to their strong performance in practical applications. In this paper, we present a light-weight neural network for Parkinson's disease diagnostics, in…