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Personalizing generative models offers a way to guide image generation with user-provided references. Current personalization methods can invert an object or concept into the textual conditioning space and compose new natural sentences for…

Intrinsically disordered regions of proteins play a crucial role in cell signaling and drug discovery. However, their high structural flexibility makes accurate residue-level prediction challenging. Existing methods often rely on…

Neural and Evolutionary Computing · Computer Science 2026-03-09 Shaokuan Wang , Pengshan Cui , Yining Qian , An-Yang Lu , Xianpeng Wang

Computational biology and bioinformatics provide vast data gold-mines from protein sequences, ideal for Language Models taken from NLP. These LMs reach for new prediction frontiers at low inference costs. Here, we trained two…

Motivation: Proteins are of great significance in living organisms. However, understanding their functions encounters numerous challenges, such as insufficient integration of multimodal information, a large number of training parameters,…

Machine Learning · Computer Science 2025-05-23 Zhicong Wang , Zicheng Ma , Ziqiang Cao , Changlong Zhou , Jun Zhang , Yiqin Gao

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein functions. Recent sequence representation learning methods based on Protein Language Models (PLMs) excel in sequence-based…

Quantitative Methods · Quantitative Biology 2023-10-19 Zuobai Zhang , Chuanrui Wang , Minghao Xu , Vijil Chenthamarakshan , Aurélie Lozano , Payel Das , Jian Tang

Text-to-image diffusion models have demonstrated remarkable progress in synthesizing high-quality images from text prompts, which boosts researches on prompt-based image editing that edits a source image according to a target prompt.…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Kejie Wang , Xuemeng Song , Meng Liu , Jin Yuan , Weili Guan

We explore a framework for protein sequence representation learning that decomposes the task between manifold learning and distributional modelling. Specifically we present a Latent Space Diffusion architecture which combines a protein…

Machine Learning · Computer Science 2025-03-25 Eoin Quinn , Ghassene Jebali , Maxime Seince , Oliver Bent

The evolution of prompt learning methodologies has driven exploration of deeper prompt designs to enhance model performance. However, current deep text prompting approaches suffer from two critical limitations: Over-reliance on constrastive…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Qiqi Zhan , Shiwei Li , Qingjie Liu , Yunhong Wang

SMILES, a crucial textual representation of molecular structures, has garnered significant attention as a foundation for pre-trained language models (LMs). However, most existing pre-trained SMILES LMs focus solely on the single-token level…

Machine Learning · Computer Science 2025-06-10 Kangjie Zheng , Siyue Liang , Junwei Yang , Bin Feng , Zequn Liu , Wei Ju , Zhiping Xiao , Ming Zhang

Designing proteins with desired functions or properties represents a core goal in synthetic biology and drug discovery. Recent advances in protein language models (PLMs) have enabled the generation of highly designable protein sequences,…

Machine Learning · Computer Science 2026-05-12 Yulin Zhang , He Cao , Zihao Jiang , Chenyi Zi , Zhipeng Zhou , Zijing Liu , Yu Li , Jia Li , Ziqi Gao

Multimodal sarcasm detection requires reasoning over cross-modal incongruities between literal expression and intended meaning, yet the specific analytical perspectives needed vary across samples due to the diversity of sarcastic…

Multiagent Systems · Computer Science 2026-05-21 Yingjia Xu , Jiulong Wu , Bowen Zhang , Baokui Guo , Siyuan Chai , Min Cao

Visual editing with diffusion models has made significant progress but often struggles with complex scenarios that textual guidance alone could not adequately describe, highlighting the need for additional non-text editing prompts. In this…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Hyeonyu Kim , Seokhoon Jeong , Seonghee Han , Chanhyuk Choi , Taehwan Kim

Protein representation learning is critical for numerous biological tasks. Recently, large transformer-based protein language models (pLMs) pretrained on large scale protein sequences have demonstrated significant success in sequence-based…

Machine Learning · Computer Science 2025-08-12 Xuefeng Liu , Songhao Jiang , Chih-chan Tien , Jinbo Xu , Rick Stevens

A crucial problem in learning disentangled image representations is controlling the degree of disentanglement during image editing, while preserving the identity of objects. In this work, we propose a simple yet effective model with the…

Machine Learning · Computer Science 2019-12-30 Zengjie Song , Oluwasanmi Koyejo , Jiangshe Zhang

This paper presents a method of decoupled pronunciation and prosody modeling to improve the performance of meta-learning-based multilingual speech synthesis. The baseline meta-learning synthesis method adopts a single text encoder with a…

Audio and Speech Processing · Electrical Eng. & Systems 2022-09-15 Yukun Peng , Zhenhua Ling

Proteins are macromolecules that perform essential functions in all living organisms. Designing novel proteins with specific structures and desired functions has been a long-standing challenge in the field of bioengineering. Existing…

Biomolecules · Quantitative Biology 2023-03-03 Chence Shi , Chuanrui Wang , Jiarui Lu , Bozitao Zhong , Jian Tang

Learning vector representation for words is an important research field which may benefit many natural language processing tasks. Two limitations exist in nearly all available models, which are the bias caused by the context definition and…

Computation and Language · Computer Science 2015-06-01 Xuefeng Yang , Kezhi Mao

Semantic segmentation suffers from significant performance degradation when the trained network is applied to a different domain. To address this issue, unsupervised domain adaptation (UDA) has been extensively studied. Despite the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Wangkai Li , Rui Sun , Huayu Mai , Tianzhu Zhang

Protein structure is key to understanding protein function and is essential for progress in bioengineering, drug discovery, and molecular biology. Recently, with the incorporation of generative AI, the power and accuracy of computational…

Cryptography and Security · Computer Science 2024-11-13 Zaixi Zhang , Ruofan Jin , Kaidi Fu , Le Cong , Marinka Zitnik , Mengdi Wang

In this paper, we proposed Adapitch, a multi-speaker TTS method that makes adaptation of the supervised module with untranscribed data. We design two self supervised modules to train the text encoder and mel decoder separately with…

Sound · Computer Science 2022-10-26 Xulong Zhang , Jianzong Wang , Ning Cheng , Jing Xiao