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Unsupervised Contrastive learning has gained prominence in fields such as vision, and biology, leveraging predefined positive/negative samples for representation learning. Data augmentation, categorized into hand-designed and model-based…

Machine Learning · Computer Science 2024-05-28 Zelin Zang , Hao Luo , Kai Wang , Panpan Zhang , Fan Wang , Stan. Z Li , Yang You

We present a new paradigm for fine-tuning large-scale visionlanguage pre-trained models on downstream task, dubbed Prompt Regularization (ProReg). Different from traditional fine-tuning which easily overfits to the downstream task data,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-14 Beier Zhu , Yulei Niu , Saeil Lee , Minhoe Hur , Hanwang Zhang

This study addresses the problem of unsupervised subword unit discovery from untranscribed speech. It forms the basis of the ultimate goal of ZeroSpeech 2019, building text-to-speech systems without text labels. In this work, unit discovery…

Audio and Speech Processing · Electrical Eng. & Systems 2020-10-29 Siyuan Feng , Tan Lee , Zhiyuan Peng

Node representations, or embeddings, are low-dimensional vectors that capture node properties, typically learned through unsupervised structural similarity objectives or supervised tasks. While recent efforts have focused on explaining…

Machine Learning · Computer Science 2025-10-17 Simone Piaggesi , André Panisson , Megha Khosla

Representation learning for proteins has primarily focused on the global understanding of protein sequences regardless of their length. However, shorter proteins (known as peptides) take on distinct structures and functions compared to…

Quantitative Methods · Quantitative Biology 2022-11-15 Gil Sadeh , Zichen Wang , Jasleen Grewal , Huzefa Rangwala , Layne Price

Disentangled representation learning offers useful properties such as dimension reduction and interpretability, which are essential to modern deep learning approaches. Although deep learning techniques have been widely applied to…

Machine Learning · Computer Science 2022-04-11 Sichen Zhao , Wei Shao , Jeffrey Chan , Flora D. Salim

Many of the existing methods for learning joint embedding of images and text use only supervised information from paired images and its textual attributes. Taking advantage of the recent success of unsupervised learning in deep neural…

Computer Vision and Pattern Recognition · Computer Science 2017-03-21 Yao-Hung Hubert Tsai , Liang-Kang Huang , Ruslan Salakhutdinov

Image-to-image translation aims to learn the mapping between two visual domains. There are two main challenges for this task: 1) lack of aligned training pairs and 2) multiple possible outputs from a single input image. In this work, we…

Computer Vision and Pattern Recognition · Computer Science 2019-12-19 Hsin-Ying Lee , Hung-Yu Tseng , Qi Mao , Jia-Bin Huang , Yu-Ding Lu , Maneesh Singh , Ming-Hsuan Yang

Bridging the exponentially growing gap between the numbers of unlabeled and labeled protein sequences, several studies adopted semi-supervised learning for protein sequence modeling. In these studies, models were pre-trained with a…

Biomolecules · Quantitative Biology 2021-09-20 Seonwoo Min , Seunghyun Park , Siwon Kim , Hyun-Soo Choi , Byunghan Lee , Sungroh Yoon

Natural language interaction is a promising direction for democratizing 3D shape design. However, existing methods for text-driven 3D shape editing face challenges in producing decoupled, local edits to 3D shapes. We address this problem by…

Computer Vision and Pattern Recognition · Computer Science 2022-12-12 Ian Huang , Panos Achlioptas , Tianyi Zhang , Sergey Tulyakov , Minhyuk Sung , Leonidas Guibas

Text-guided audio editing aims to modify specific acoustic events while strictly preserving non-target content. Despite recent progress, existing approaches remain fundamentally limited. Training-free methods often suffer from signal…

Sound · Computer Science 2026-01-21 Ye Tao , Wen Wu , Chao Zhang , Mengyue Wu , Shuai Wang , Xuenan Xu

Disentangled representation learning plays a pivotal role in making representations controllable, interpretable and transferable. Despite its significance in the domain, the quest for reliable and consistent quantitative disentanglement…

Machine Learning · Computer Science 2024-10-07 Sahib Julka , Yashu Wang , Michael Granitzer

Prompt-based techniques, such as prompt-tuning and prefix-tuning, have gained prominence for their efficiency in fine-tuning large pre-trained models. Despite their widespread adoption, the theoretical foundations of these methods remain…

Machine Learning · Computer Science 2025-04-03 Minh Le , Chau Nguyen , Huy Nguyen , Quyen Tran , Trung Le , Nhat Ho

Deciphering the function of unseen protein sequences is a fundamental challenge with broad scientific impact, yet most existing methods depend on task-specific adapters or large-scale supervised fine-tuning. We introduce the…

Machine Learning · Computer Science 2025-10-14 Xinhui Chen , Zuchao Li , Mengqi Gao , Yufeng Zhang , Chak Tou Leong , Haoyang Li , Jiaqi Chen

We present a new approach for representing and reconstructing multidimensional magnetic resonance imaging (MRI) data. Our method builds on a novel, learned feature-based image representation that disentangles different types of features,…

Image and Video Processing · Electrical Eng. & Systems 2026-01-01 Ruiyang Zhao , Fan Lam

Recent advancements in image editing have utilized large-scale multimodal models to enable intuitive, natural instruction-driven interactions. However, conventional methods still face significant challenges, particularly in spatial…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Qianqian Sun , Jixiang Luo , Dell Zhang , Xuelong Li

Systematic identification of protein function is a key problem in current biology. Most traditional methods fail to identify functionally equivalent proteins if they lack similar sequences, structural data or extensive manual annotations.…

Genomics · Quantitative Biology 2016-03-08 Dan Ofer

Generative models have been widely studied in computer vision. Recently, diffusion models have drawn substantial attention due to the high quality of their generated images. A key desired property of image generative models is the ability…

Computer Vision and Pattern Recognition · Computer Science 2022-12-20 Qiucheng Wu , Yujian Liu , Handong Zhao , Ajinkya Kale , Trung Bui , Tong Yu , Zhe Lin , Yang Zhang , Shiyu Chang

Methods for knowledge editing and unlearning in large language models seek to edit or remove undesirable knowledge or capabilities without compromising general language modeling performance. This work investigates how mechanistic…

Machine Learning · Computer Science 2024-12-06 Phillip Guo , Aaquib Syed , Abhay Sheshadri , Aidan Ewart , Gintare Karolina Dziugaite

Protein is linked to almost every life process. Therefore, analyzing the biological structure and property of protein sequences is critical to the exploration of life, as well as disease detection and drug discovery. Traditional protein…

Machine Learning · Computer Science 2021-12-08 Yijia Xiao , Jiezhong Qiu , Ziang Li , Chang-Yu Hsieh , Jie Tang