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Modern deep neural networks achieved remarkable progress in medical image segmentation tasks. However, it has recently been observed that they tend to produce overconfident estimates, even in situations of high uncertainty, leading to…

Computer Vision and Pattern Recognition · Computer Science 2023-06-05 Agostina Larrazabal , Cesar Martinez , Jose Dolz , Enzo Ferrante

Typical machine learning frameworks heavily rely on an underlying assumption that training and test data follow the same distribution. In medical imaging which increasingly begun acquiring datasets from multiple sites or scanners, this…

Computer Vision and Pattern Recognition · Computer Science 2021-02-18 Xingchen Zhao , Anthony Sicilia , Davneet Minhas , Erin O'Connor , Howard Aizenstein , William Klunk , Dana Tudorascu , Seong Jae Hwang

In the past years, deep learning has seen an increase in usage in the domain of histopathological applications. However, while these approaches have shown great potential, in high-risk environments deep learning models need to be able to…

Image and Video Processing · Electrical Eng. & Systems 2023-11-17 Hendrik A. Mehrtens , Alexander Kurz , Tabea-Clara Bucher , Titus J. Brinker

Uncertainty quantification is essential for the reliable deployment of machine learning models to high-stakes application domains. Uncertainty quantification is all the more challenging when training distribution and test distribution are…

Machine Learning · Computer Science 2022-06-07 Yaodong Yu , Stephen Bates , Yi Ma , Michael I. Jordan

We propose a framework for learning calibrated uncertainties under domain shifts, where the source (training) distribution differs from the target (test) distribution. We detect such domain shifts via a differentiable density ratio…

Machine Learning · Computer Science 2024-02-07 Haoxuan Wang , Zhiding Yu , Yisong Yue , Anima Anandkumar , Anqi Liu , Junchi Yan

When neural networks are confronted with unfamiliar data that deviate from their training set, this signifies a domain shift. While these networks output predictions on their inputs, they typically fail to account for their level of…

Machine Learning · Computer Science 2025-09-09 Fin Amin , Jung-Eun Kim

Existing training criteria in automatic speech recognition(ASR) permit the model to freely explore more than one time alignments between the feature and label sequences. In this paper, we use entropy to measure a model's uncertainty, i.e.…

Computation and Language · Computer Science 2022-12-26 Ehsan Variani , Ke Wu , David Rybach , Cyril Allauzen , Michael Riley

Unsupervised domain adaptation methods seek to generalize effectively on unlabeled test data, especially when encountering the common challenge in time series data that distribution shifts occur between training and testing datasets. In…

Machine Learning · Computer Science 2025-08-27 Weide Liu , Xiaoyang Zhong , Lu Wang , Jingwen Hou , Yuemei Luo , Jiebin Yan , Yuming Fang

Despite the remarkable results that can be achieved by data-driven intelligent fault diagnosis techniques, they presuppose the same distribution of training and test data as well as sufficient labeled data. Various operating states often…

Machine Learning · Computer Science 2023-11-27 Zixuan Wang , Haoran Tang , Haibo Wang , Bo Qin , Mark D. Butala , Weiming Shen , Hongwei Wang

In recent years, several convolutional neural network (CNN) methods have been proposed for the automated white matter lesion segmentation of multiple sclerosis (MS) patient images, due to their superior performance compared with those of…

Computer Vision and Pattern Recognition · Computer Science 2018-06-01 Sergi Valverde , Mostafa Salem , Mariano Cabezas , Deborah Pareto , Joan C. Vilanova , Lluís Ramió-Torrentà , Àlex Rovira , Joaquim Salvi , Arnau Oliver , Xavier Lladó

This paper explores uncertainty quantification (UQ) as an indicator of the trustworthiness of automated deep-learning (DL) tools in the context of white matter lesion (WML) segmentation from magnetic resonance imaging (MRI) scans of…

White matter hyperintensities (WMH) are key imaging markers in cognitive aging, Alzheimer's disease (AD), and related dementias. Although automated methods for WMH segmentation have advanced, most provide only global lesion load and…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Julia Machnio , Mads Nielsen , Mostafa Mehdipour Ghazi

While recent computer vision algorithms achieve impressive performance on many benchmarks, they lack robustness - presented with an image from a different distribution, (e.g. weather or lighting conditions not considered during training),…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Sebastian Cygert , Bartłomiej Wróblewski , Karol Woźniak , Radosław Słowiński , Andrzej Czyżewski

Modern deep neural networks (DNNs) are highly accurate on many recognition tasks for overhead (e.g., satellite) imagery. However, visual domain shifts (e.g., statistical changes due to geography, sensor, or atmospheric conditions) remain a…

Computer Vision and Pattern Recognition · Computer Science 2023-08-15 Can Yaras , Kaleb Kassaw , Bohao Huang , Kyle Bradbury , Jordan M. Malof

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

Uncertainty estimation plays an important role for future reliable deployment of deep segmentation models in safety-critical scenarios such as medical applications. However, existing methods for uncertainty estimation have been limited by…

Computer Vision and Pattern Recognition · Computer Science 2023-11-07 Hongzheng Yang , Cheng Chen , Yueyao Chen , Markus Scheppach , Hon Chi Yip , Qi Dou

White Matter Hyperintensities (WMH) are areas of the brain that have higher intensity than other normal brain regions on Magnetic Resonance Imaging (MRI) scans. WMH is often associated with small vessel disease in the brain, making early…

Image and Video Processing · Electrical Eng. & Systems 2023-05-09 Muhammad Noor Dwi Eldianto , Muhammad Febrian Rachmadi , Wisnu Jatmiko

White Matter Hyperintensities (WMH) are key neuroradiological markers of small vessel disease present in brain MRI. Assessment of WMH is important in research and clinics. However, WMH are challenging to segment due to their high…

Automatic and accurate segmentation for retinal and choroidal layers of Optical Coherence Tomography (OCT) is crucial for detection of various ocular diseases. However, because of the variations in different equipments, OCT data obtained…

Computer Vision and Pattern Recognition · Computer Science 2019-09-02 Jiexiang Wang , Cheng Bian , Meng Li , Xin Yang , Kai Ma , Wenao Ma , Jin Yuan , Xinghao Ding , Yefeng Zheng

Deep learning models for medical image segmentation often struggle when deployed across different datasets due to domain shifts - variations in both image appearance, known as style, and population-dependent anatomical characteristics,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-16 Hoda Kalabizadeh , Ludovica Griffanti , Pak-Hei Yeung , Ana I. L. Namburete , Nicola K. Dinsdale , Konstantinos Kamnitsas
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