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Uncertainty estimation is important for interpreting the trustworthiness of machine learning models in many applications. This is especially critical in the data-driven active learning setting where the goal is to achieve a certain accuracy…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Bo Li , Tommy Sonne Alstrøm

Foundation models for segmentation such as the Segment Anything Model (SAM) family exhibit strong zero-shot performance, but remain vulnerable in shifted or limited-knowledge domains. This work investigates whether uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Jesse Brouwers , Xiaoyan Xing , Alexander Timans

Trained using only image class label, deep weakly supervised methods allow image classification and ROI segmentation for interpretability. Despite their success on natural images, they face several challenges over histology data where ROI…

Image and Video Processing · Electrical Eng. & Systems 2022-05-13 Soufiane Belharbi , Jérôme Rony , Jose Dolz , Ismail Ben Ayed , Luke McCaffrey , Eric Granger

Supervised learning has proved effective for medical image analysis. However, it can utilize only the small labeled portion of data; it fails to leverage the large amounts of unlabeled data that is often available in medical image datasets.…

Computer Vision and Pattern Recognition · Computer Science 2020-04-28 Gaurav Fotedar , Nima Tajbakhsh , Shilpa Ananth , Xiaowei Ding

Image segmentation is a critical step in computational biomedical image analysis, typically evaluated using metrics like the Dice coefficient during training and validation. However, in clinical settings without manual annotations,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Sikha O K , Meritxell Riera-Marín , Adrian Galdran , Javier García Lopez , Julia Rodríguez-Comas , Gemma Piella , Miguel A. González Ballester

Deep learning (DL) methods for white matter lesion (WML) segmentation in MRI suffer a reduction in performance when applied on data from a scanner or centre that is out-of-distribution (OOD) from the training data. This is critical for…

Image and Video Processing · Electrical Eng. & Systems 2023-07-11 Abdollah Ghazvanchahi , Pejman Jahbedar Maralani , Alan R. Moody , April Khademi

As machine learning models are increasingly deployed in dynamic environments, it becomes paramount to assess and quantify uncertainties associated with distribution shifts. A distribution shift occurs when the underlying data-generating…

Methodology · Statistics 2024-10-08 Jiawei Ge , Debarghya Mukherjee , Jianqing Fan

Automatic segmentation of white matter hyperintensities in magnetic resonance images is of paramount clinical and research importance. Quantification of these lesions serve as a predictor for risk of stroke, dementia and mortality. During…

Image and Video Processing · Electrical Eng. & Systems 2020-09-11 Julian Alberto Palladino , Diego Fernandez Slezak , Enzo Ferrante

This paper introduces an efficient sub-model ensemble framework aimed at enhancing the interpretability of medical deep learning models, thus increasing their clinical applicability. By generating uncertainty maps, this framework enables…

Machine Learning · Computer Science 2024-11-11 Weijie Chen , Alan McMillan

Despite the superior performance of Deep Learning (DL) on numerous segmentation tasks, the DL-based approaches are notoriously overconfident about their prediction with highly polarized label probability. This is often not desirable for…

Image and Video Processing · Electrical Eng. & Systems 2021-12-14 Sungmin Hong , Anna K. Bonkhoff , Andrew Hoopes , Martin Bretzner , Markus D. Schirmer , Anne-Katrin Giese , Adrian V. Dalca , Polina Golland , Natalia S. Rost

Any novel medical imaging modality that differs from previous protocols e.g. in the number of imaging channels, introduces a new domain that is heterogeneous from previous ones. This common medical imaging scenario is rarely considered in…

Image and Video Processing · Electrical Eng. & Systems 2021-09-22 Eleni Chiou , Francesco Giganti , Shonit Punwani , Iasonas Kokkinos , Eleftheria Panagiotaki

Many existing approaches for unsupervised domain adaptation (UDA) focus on adapting under only data distribution shift and offer limited success under additional cross-domain label distribution shift. Recent work based on self-training…

Computer Vision and Pattern Recognition · Computer Science 2021-10-12 Viraj Prabhu , Shivam Khare , Deeksha Kartik , Judy Hoffman

Calibration and uncertainty estimation are crucial topics in high-risk environments. We introduce a new diversity regularizer for classification tasks that uses out-of-distribution samples and increases the overall accuracy, calibration and…

Machine Learning · Computer Science 2022-10-21 Hendrik Alexander Mehrtens , Camila González , Anirban Mukhopadhyay

Accurate lesion segmentation is crucial for clinical diagnosis and treatment planning. However, lesions often resemble surrounding tissues and exhibit ill-defined boundaries, leading to unstable predictions in boundary/transition regions.…

Computer Vision and Pattern Recognition · Computer Science 2026-05-01 Shuokun Cheng , Jinghao Shi , Kun Sun

Deep neural networks often produce overconfident predictions, undermining their reliability in safety-critical applications. This miscalibration is further exacerbated under distribution shift, where test data deviates from the training…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Yilin Zhang , Cai Xu , You Wu , Ziyu Guan , Wei Zhao

Neural network classifiers trained with cross-entropy loss achieve strong predictive accuracy but lack the capability to provide inherent predictive uncertainty estimates, thus requiring external techniques to obtain these estimates. In…

Machine Learning · Statistics 2026-04-08 Courtney Franzen , Farhad Pourkamali-Anaraki

Medical image segmentation is a fundamental and critical step in many clinical approaches. Semi-supervised learning has been widely applied to medical image segmentation tasks since it alleviates the heavy burden of acquiring…

Image and Video Processing · Electrical Eng. & Systems 2022-08-29 Yichi Zhang , Rushi Jiao , Qingcheng Liao , Dongyang Li , Jicong Zhang

Miscalibration in deep learning refers to there is a discrepancy between the predicted confidence and performance. This problem usually arises due to the overfitting problem, which is characterized by learning everything presented in the…

Machine Learning · Computer Science 2024-07-16 Zongbo Han , Yifeng Yang , Changqing Zhang , Linjun Zhang , Joey Tianyi Zhou , Qinghua Hu

In this work, we face the problem of unsupervised domain adaptation with a novel deep learning approach which leverages on our finding that entropy minimization is induced by the optimal alignment of second order statistics between source…

Computer Vision and Pattern Recognition · Computer Science 2017-11-29 Pietro Morerio , Jacopo Cavazza , Vittorio Murino

Bearing fault diagnosis under varying working conditions faces challenges, including a lack of labeled data, distribution discrepancies, and resource constraints. To address these issues, we propose a progressive knowledge distillation…

Machine Learning · Computer Science 2025-11-04 Mohammadreza Kavianpour , Parisa Kavianpour , Amin Ramezani , Mohammad TH Beheshti