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Drug combination therapy is a well-established strategy for disease treatment with better effectiveness and less safety degradation. However, identifying novel drug combinations through wet-lab experiments is resource intensive due to the…

Machine Learning · Computer Science 2023-01-18 Zhihang Hu , Qinze Yu , Yucheng Guo , Taifeng Wang , Irwin King , Xin Gao , Le Song , Yu Li

Causal discovery has been widely studied, yet many existing methods rely on strong assumptions or fall into two extremes: either depending on costly interventional signals or partial ground truth as strong priors, or adopting purely data…

Machine Learning · Computer Science 2026-03-24 Wenbo Xu , Yue He , Yunhai Wang , Xingxuan Zhang , Kun Kuang , Yueguo Chen , Peng Cui

This paper introduces a novel direct approach to system identification of dynamic networks with missing data based on maximum likelihood estimation. Dynamic networks generally present a singular probability density function, which poses a…

Systems and Control · Electrical Eng. & Systems 2024-07-31 João Victor Galvão da Mata , Anders Hansson , Martin S. Andersen

Causal discovery is challenging in general dynamical systems because, without strong structural assumptions, the underlying causal graph may not be identifiable even from interventional data. However, many real-world systems exhibit…

Machine Learning · Computer Science 2026-04-07 Panayiotis Panayiotou , Özgür Şimşek

We propose a new method to quantify the impact of cyber attacks in Cyber Physical Systems (CPSs). In particular, our method allows to identify the Design Parameter (DPs) affected due to a cyber attack launched on a different set of DPs in…

Cryptography and Security · Computer Science 2023-07-27 Rajib Ranjan Maiti , Sridhar Adepu , Emil Lupu

Cyber-physical systems (CPS) offer immense optimization potential for manufacturing processes through the availability of multivariate time series data of actors and sensors. Based on automated analysis software, the deployment of adaptive…

Systems and Control · Electrical Eng. & Systems 2024-01-17 Brandon K. Sai , Jonas Gram , Thomas Bauernhansl

An important goal across most scientific fields is the discovery of causal structures underling a set of observations. Unfortunately, causal discovery methods which are based on correlation or mutual information can often fail to identify…

Computer Vision and Pattern Recognition · Computer Science 2021-04-29 Matthew J. Vowels , Necati Cihan Camgoz , Richard Bowden

Causal discovery between collections of time-series data can help diagnose causes of symptoms and hopefully prevent faults before they occur. However, reliable causal discovery can be very challenging, especially when the data acquisition…

Machine Learning · Computer Science 2023-01-12 Haonan Chen , Bo Yuan Chang , Mohamed A. Naiel , Georges Younes , Steven Wardell , Stan Kleinikkink , John S. Zelek

Causal discovery aims to infer causal relationships among variables from observational data, typically represented by a directed acyclic graph (DAG). Most existing methods assume independent and identically distributed observations, an…

Methodology · Statistics 2026-03-27 Alex Chen , Qing Zhou

Thanks to technological advances leading to near-continuous time observations, emerging multivariate point process data offer new opportunities for causal discovery. However, a key obstacle in achieving this goal is that many relevant…

Machine Learning · Statistics 2021-12-15 Xu Wang , Ali Shojaie

Small disturbances can trigger functional breakdowns in complex systems. A challenging task is to infer the structural cause of a disturbance in a networked system, soon enough to prevent a catastrophe. We present a graph neural network…

Physics and Society · Physics 2020-06-11 Edward Laurence , Charles Murphy , Guillaume St-Onge , Xavier Roy-Pomerleau , Vincent Thibeault

Causal inference is made challenging by confounding, selection bias, and other complications. A common approach to addressing these difficulties is the inclusion of auxiliary data on the superpopulation of interest. Such data may measure a…

Methodology · Statistics 2024-04-16 Jaron J. R. Lee , AmirEmad Ghassami , Ilya Shpitser

Large Language Models (LLMs) have achieved significant advancements, but the increasing complexity of tasks and higher performance demands highlight the need for continuous improvement. Some approaches utilize synthetic data generated by…

Artificial Intelligence · Computer Science 2025-06-23 Haokun Zhao , Jinyi Han , Jiaqing Liang , Yanghua Xiao , Xiaojun Meng , Jiansheng Wei

Supervised machine learning has enabled accurate pathology detection in brain MRI, but requires training data from diseased subjects that may not be readily available in some scenarios, for example, in the case of rare diseases.…

Image and Video Processing · Electrical Eng. & Systems 2025-06-13 Ana Lawry Aguila , Peirong Liu , Oula Puonti , Juan Eugenio Iglesias

Large-scale vision models like SAM have extensive visual knowledge, yet their general nature and computational demands limit their use in specialized tasks like medical image segmentation. In contrast, task-specific models such as U-Net++…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 Yuchen Mao , Hongwei Li , Yinyi Lai , Giorgos Papanastasiou , Peng Qi , Yunjie Yang , Chengjia Wang

Causal learning is a fundamental problem in statistics and science, offering insights into predicting the effects of unseen treatments on a system. Despite recent advances in this topic, most existing causal discovery algorithms operate…

Machine Learning · Statistics 2024-02-27 Muralikrishnna G. Sethuraman , Faramarz Fekri

Systems that can automatically analyze EEG signals can aid neurologists by reducing heavy workload and delays. However, such systems need to be first trained using a labeled dataset. While large corpuses of EEG data exist, a fraction of…

Machine Learning · Computer Science 2019-11-11 Subhrajit Roy , Kiran Kate , Martin Hirzel

The automation of the medical evidence acquisition and diagnosis process has recently attracted increasing attention in order to reduce the workload of doctors and democratize access to medical care. However, most works proposed in the…

Computation and Language · Computer Science 2022-10-14 Arsene Fansi Tchango , Rishab Goel , Julien Martel , Zhi Wen , Gaetan Marceau Caron , Joumana Ghosn

In the modern world, we are permanently using, leveraging, interacting with, and relying upon systems of ever higher sophistication, ranging from our cars, recommender systems in e-commerce, and networks when we go online, to integrated…

Artificial Intelligence · Computer Science 2023-06-23 Patrick Rodler

We introduce a new computer aided detection and diagnosis system for lung cancer screening with low-dose CT scans that produces meaningful probability assessments. Our system is based entirely on 3D convolutional neural networks and…

Computer Vision and Pattern Recognition · Computer Science 2020-01-22 Onur Ozdemir , Rebecca L. Russell , Andrew A. Berlin