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Variable importance measures are the main tools to analyze the black-box mechanisms of random forests. Although the mean decrease accuracy (MDA) is widely accepted as the most efficient variable importance measure for random forests, little…
Malaria remains a major public health concern in Ethiopia, particularly in the Amhara Region, where seasonal and unpredictable transmission patterns make prevention and control challenging. Accurately forecasting malaria outbreaks is…
The emergence of cross species interactions at protein level is a part of molecular mechanisms that lead to parasitic diseases. Comprehensive modelling can capture such interactions and could be useful to understand their pathophysiology…
A malaria model is formulated which includes the enhanced attractiveness of infectious humans to mosquitoes, as result of host manipulation by malaria parasite, and the human behavior, represented by insecticide-treated bed nets usage. The…
Malaria is a life-threatening infectious disease caused by Plasmodium parasites, which poses a significant public health challenge worldwide, particularly in tropical and subtropical regions. Timely and accurate detection of malaria…
The sterile insect technique has emerged recently as a biologically secure and effective tool for suppressing wild mosquito pests. To improve the performance of this strategy, understanding the interaction between wild and sterile…
Plasmodium falciparum malaria still poses one of the greatest threats to human life with over 200 million cases globally leading to half-million deaths annually. Of these, 90% of cases and of the mortality occurs in sub-Saharan Africa,…
Background Elimination of malaria can only be achieved through removal of all vectors or complete depletion of the infectious reservoir in humans. Mechanistic models can be built to synthesize diverse observations from the field collected…
The prevention of domestic violence (DV) have aroused serious concerns in Taiwan because of the disparity between the increasing amount of reported DV cases that doubled over the past decade and the scarcity of social workers. Additionally,…
One of the main causes of death around the globe is malaria. Researchers have sought to develop predictive models for malaria outbreaks based on meteorological data, climate data and the breeding cycle of Plasmodium, the causative agent of…
The relationship between epidemiology, mathematical modeling and computational tools allows to build and test theories on the development and battling of a disease. This PhD thesis is motivated by the study of epidemiological models applied…
The assumption that vector mortality remains constant with age is used widely to assess malaria transmission risk and predict the public health consequences of vector control strategies. However, laboratory studies commonly demonstrate…
Schistosomiasis, a neglected tropical disease caused by Schistosoma parasites, remains a major global health challenge. The Schistosoma mansoni thioredoxin glutathione reductase (SmTGR) is essential for parasite redox balance and immune…
We develop a variable population age-structured ODE model to investigate the role of Intermittent Preventive Treatment (IPT) in averting malaria-induced mortalities in children, as well as its related cost in promoting the spread of…
A mathematical model of Zika virus transmission incorporating human movement between rural areas and nearby forests is presented to investigate the role of human movement in the spread of Zika virus infections in human and mosquito…
There has been renewed interest in the use of sporozoite-based approaches for malaria vaccination and controlled human infections, and several sets of human challenge studies have recently completed. A study undertaken in Tanzania and…
The site-specific management of weeds in grassland is often challenging because different weed control strategies have different trade-offs regarding the required resources and treatment efficiency. So, the question arises whether a wide…
This paper presents an age-structured, non-autonomous logistic model describing the aquatic and adult stages of the dynamics of malaria-vector mosquitoes. We propose a biological control strategy targeting the aquatic compartment and…
Recent statistics of malaria shows that over 200 million cases and estimated deaths of nearly half a million occur globally. Africa alone accounts for almost 90% of the cases. Several studies have been conducted to understand the disease…
Malaria is considered one of the deadliest diseases in today world which causes thousands of deaths per year. The parasites responsible for malaria are scientifically known as Plasmodium which infects the red blood cells in human beings.…