Related papers: Llama-Affinity: A Predictive Antibody Antigen Bind…

The increasing integration of Large Language Models (LLMs) into society necessitates robust defenses against vulnerabilities from jailbreaking and adversarial prompts. This project proposes a recursive framework for enhancing the resistance…

Protein-ligand binding affinity prediction is essential for drug discovery and toxicity assessment. While machine learning (ML) promises fast and accurate predictions, its progress is constrained by the availability of reliable data. In…

Protein-ligand binding complexes are ubiquitous and essential to life. Protein-ligand binding affinity prediction (PLA) quantifies the binding strength between ligands and proteins, providing crucial insights for discovering and designing…

Modern media firms require automated and efficient methods to identify content that is most engaging and appealing to users. Leveraging a large-scale dataset from Upworthy (a news publisher), which includes 17,681 headline A/B tests, we…

Affinity maturation produces antibodies that bind antigens with high specificity by accumulating mutations in the antibody sequence. Mapping out the antibody-antigen affinity landscape can give us insight into the accessible paths during…

Accurately determining a change in protein binding affinity upon mutations is important for the discovery and design of novel therapeutics and to assist mutagenesis studies. Determination of change in binding affinity upon mutations…

Despite the central role that antibodies play in the adaptive immune system and in biotechnology, much remains unknown about the quantitative relationship between an antibody's amino acid sequence and its antigen binding affinity. Here we…

Antibodies have become an important class of therapeutic agents to treat human diseases. To accelerate therapeutic antibody discovery, computational methods, especially machine learning, have attracted considerable interest for predicting…

Large language models (LLMs) have achieved near-human performance across diverse reasoning tasks, yet their deployment on resource-constrained Internet-of-Things (IoT) devices remains impractical due to massive parameter footprints and…

The de novo design of ligand-binding proteins with tailored functions is essential for advancing biotechnology and molecular medicine, yet existing AI approaches are limited by scarce protein-ligand complex data. To circumvent this data…

Computational models that accurately predict the binding affinity of an input protein-chemical pair can accelerate drug discovery studies. These models are trained on available protein-chemical interaction datasets, which may contain…

Motivation: Prediction of the interaction affinity between proteins and compounds is a major challenge in the drug discovery process. WideDTA is a deep-learning based prediction model that employs chemical and biological textual sequence…

Large Language Models (LLMs) are widely deployed in real-world systems. Given their broader applicability, prompt engineering has become an efficient tool for resource-scarce organizations to adopt LLMs for their own purposes. At the same…

Document layout understanding remains data-intensive despite advances in semi-supervised learning. We present a framework that enhances semi-supervised detection by fusing visual predictions with structural priors from text-pretrained LLMs…

Large language models (LLMs) are increasingly being used as decision aids. However, users have diverse values and preferences that can affect their decision-making, which requires novel methods for LLM alignment and personalization.…

Large Language Models (LLMs) are increasingly used in intelligent systems that perform reasoning, summarization, and code generation. Their ability to follow natural-language instructions, while powerful, also makes them vulnerable to a new…

Local feature matching has long been a fundamental component of 3D vision systems such as Structure-from-Motion (SfM), yet progress has lagged behind the rapid advances of modern data-driven approaches. The newer approaches, such as…

Vision--Language Models (VLMs) show significant promise for Medical Visual Question Answering (VQA), yet their deployment in clinical settings is hindered by severe vulnerability to adversarial attacks. Standard adversarial training, while…

We conducted extensive experiments on domain adaptation of the Meta-Llama-3-70B-Instruct model on SEC data, exploring its performance on both general and domain-specific benchmarks. Our focus included continual pre-training (CPT) and model…

Large language models (LLMs) have made significant advancements in natural language processing (NLP). Broad corpora capture diverse patterns but can introduce irrelevance, while focused corpora enhance reliability by reducing misleading…